Implication of the complement system in the induction of anti-glomerular basement membrane glomerulonephritis in WKY rats

Pathology International

Volumn 53, Issue 11, 2003, Pages 757-761

  Shike, Tatsuhiko ^a   Isome, Masato ^a   Mizuno, Masashi ^c   Suzuki, Junzo ^a   Matsuo, Seiichi ^c   Yamamoto, Tadashi ^b   Suzuki, Hitoshi ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Anti glomerular basement membrane glomerulonephritis; Cobra venom factor; Complement system

Indexed keywords

CD8 ANTIGEN; COBROTOXIN; COMPLEMENT COMPONENT C3; GLOMERULUS BASEMENT MEMBRANE ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; COMPLEMENT SYSTEM; CONTROLLED STUDY; FEMALE; GLOMERULONEPHRITIS; IMMUNOPATHOLOGY; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN INDUCTION; PROTEINURIA; RAT; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ANIMALS; ANTIBODIES; BASEMENT MEMBRANE; CD8-POSITIVE T-LYMPHOCYTES; COMPLEMENT C3; FEMALE; GLOMERULONEPHRITIS; KIDNEY GLOMERULUS; MACROPHAGES; MONOCYTES; PROTEINURIA; RATS; RATS, INBRED WKY;

EID: 0344944828     PISSN: 13205463     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1827.2003.01555.x     Document Type: Article

References (14)

1. Boyce NW, Holdsworth SR. Anti-glomerular basement membrane antibody-induced experimental glomerulonephritis: evidence for dose-dependent, direct antibody and complement-induced, cell-independent injury. J Immunol 1985; 135: 3918-21.
2. Blantz RC, Tucker BJ, Wilson CB. The acute effects of anti-glomerular basement membrane antibody upon glomerular filtration in the rat. The influence of dose and complement depletion. J Clin Invest 1978; 61: 910-21.
3. Sheerin NS, Springall T, Carroll MC, Hartley B, Sacks SH. Protection against anti-glomerular basement membrane (GBM)-mediated nephritis in C3- and C4-deficient mice. Clin Exp Immunol 1997; 110: 403-409.
4. Sheerin NS, Springall T, Abe K, Sacks SH. Protection and injury: the differing roles of complement in the development of glomerular injury. Eur J Immunol 2001; 31: 1255-60.
5. Kawasaki K, Yaoita E, Yamamoto T, Kihara I. Depletion of CD8 positive cells in nephrotoxic serum nephritis of WKY rats. Kidney Int 1992; 41: 1517-26.
6. Fujinaka H, Yamamoto T, Takeya M et al. Suppression of anti-glomerular basement membrane nephritis by administration of anti-monocyte chemoattractant protein-1 antibody in WKY rats. J Am Soc Nephrol 1997; 8: 1174-8.
7. Isome M, Yamamoto T, Adhikary LP et al. A role of monocytes/macrophages in anti-glomerular basement membrane glomerulonephritis in WKY rats. J Am Soc Nephrol 1998; 9: 458A.
8. Matsuo S, Ichida S, Takizawa H et al. In vivo effects of monoclonal antibodies that functionally inhibit complement regulatory proteins in rats. J Exp Med 1994; 180: 1619-27.
9. Mizuno M, Nishikawa K, Goodfellow RM, Piddlesden SJ, Morgan BP, Matsuo S. The effect of functional suppression of a membrane-bound complement regulatory protein, CD59, in the synovial tissue in rats. Arthritis Rheum 1997; 40: 527-33.
10. Bradford MM. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-54.
11. Yamamoto T, Wilson CB. Complement dependence of antibody induced masangial cell injury in the rat. J Immunol 1987; 138: 3758-65.
12. Bolton WK. Rapidly progressive glomerulonephritis. Semin Nephrol 1996; 16: 517-26.
13. Couser WG, Baker PJ, Adler S. Complement and the direct mediation of immunoglomerular injury. Kidney Int 1985; 28: 879-900.
14. Hebert LA, Cosio FG, Birmigham DJ. The role of the complement system in renal injury. Semin Nephrol 1992; 12: 408-27.