Therapeutic mechanism of ginkgo biloba exocarp polysaccharides on gastric cancer

World Journal of Gastroenterology

Volumn 9, Issue 11, 2003, Pages 2424-2427

  Xu, Ai Hua ^a   Chen, Hua Sheng ^a   Sun, Bu Chan ^a   Xiang, Xiao Ren ^b   Chu, Yun Fei ^c   Zhai, Fan ^d   Jia, Ling Chang ^d  

^a YANGZHOU UNIVERSITY   (China)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c Medical College of Southeast University   (China)

^d NORTHERN JIANGSU PEOPLE S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; GINKGO BILOBA EXTRACT; MYC PROTEIN; POLYSACCHARIDE; PROTEIN BCL 2; PROTEIN C FOS;

ADULT; AGED; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL ULTRASTRUCTURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; FEMALE; FLOW CYTOMETRY; GASTROSCOPE; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; STOMACH CANCER; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL;

EID: 0344899182     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v9.i11.2424     Document Type: Article

References (32)

1. Xu AH, Chen HS, Xiang XR, Gu WR, Zhang HQ. The suppressive effects of ginkgo biloba exocarp polysaccharides (GBEP) on tumor in mice. Zhongyao Iaoli yu Linchuang 1996; 12: 24-26
2. Chen HS, Xu AH, Wang Y, Wang Q, Wang XL. Influence of ginkgo biloba exocarp polysaccharides (GBEP) on interleukin-2 (IL-2) activity and solubility interleukin-2 receptor (sIL-2R) level in mice under lower immune function. Zhongyao Yaoli yu Linchuang 2001; 17: 17-19
3. Zhai F, Chen HS. Clinical observation on effects of ginkgo biloba exocarp polysaccharides (GBEP) in treatment of 84 cases in cancer of middle-late stage. Liaoning Zhongyi Zazhi 2002; 29: 564
4. Xu A, Chen H, Wang L, Wang Q. Influence of Ginkgo biloba L. exocarp polysaccharides on serum superoxide dismutase activity and malondialdehyde level in mice under different states. Zhongguo Zhongyao Zazhi 1998; 23: 746-747
5. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63
6. Wu Q, Chen Z, Su W. Mechanism of inhibition on activator protein-1 activity by all-trans retinoic acid in gastric cancer cells. Chin Med J 2000; 113: 972-976
7. Liu C, Gao P, Qian J, Yan W. Immunological study on the antitumor effects of fungus polysaccharides compounds. Wei Sheng Yan Jiu 2000; 29: 178-180
8. Wang Z, Wang Y, Huang Z, Zhong S, Wu Y, Yu L. Study on antitumor effect and mechanism of aloe polysaccharides. Zhong Yao Cai 2001; 24: 350-353
9. Kodama N, Komuta K, Sakai N, Nanba H. Effects of D-Fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells. Biol Pharm Bull 2002; 25: 1647-1650
10. Lu X, Su M, Li Y, Zeng L, Liu X, Li J, Zheng B, Wang S. Effect of Acanthopanax giraldii Harms Var. Hispidus Hoo polysaccharides on the human gastric cancer cell line SGC-7901 and its possible mechanism. Chin Med J 2002; 115: 716-721
11. Yan J, Xu YH. Tributyrin inhibits human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest. World J Gastroenterol 2003; 9: 660-664
12. Su M, Dai M, Lu X, Li H, Liu J. Effect of traditional Chinese medicine compounds aining on the expression of apoptosis inducing genes of human gastric cancer cell. Zhong Yao Cai 2002; 25: 563-566
13. Gao F, Yi J, Shi GY, Li H, Shi XG, Tang XM. The sensitivity of digestive tract tumor cells to As2O3 is associated with the inherent cellular level of reactive oxygen species. World J Gastroenterol 2002; 8: 36-39
14. Kimura H, Konishi K, Kaji M, Maeda K, Yabushita K, Tsuji M, Ogino H, Satomura Y, Unoura M, Miwa A. Apoptosis, cell proliferation and expression of oncogenes in gastric carcinomas induced by preoperative administration of 5-fluorouracil. Oncol Rep 2000; 7: 971-976
15. Sugamura K, Makino M, Shirai H, Kimura O, Maeta M, Itoh H, Kaibara N. Enhanced induction of apoptosis of human gastric carcinoma cells after preoperative treatment with 5-fluorouracil. Cancer 1997; 79: 12-17
16. Masutani M, Suzuki J, Matsuda T, Dochin A, Sadaoka K, Nomura A, Ohira K, Takahashi K, Yamazaki K, Dosaka-Akita H, Nishimura M, Kawakami Y. Increased apoptosis associated with depressed type of early intestinal gastric cancer. Jpn J Cancer Res 2001; 92: 1214-1219
17. Zhao AG, Zhao HL, Jin XJ, Yang JK, Tang LD. Effects of Chinese jianpi herbs on cell apoptosis and related gene expression in human gastric cancer grafted onto nude mice. World J Gastroenterol 2002; 8: 792-796
18. Cao J, Qiao Y, Min J. Bcl-2 anti-sense oligonucleotide sensitizes Fas-mediated apoptosis of gastric cancer cells. Zhonghua Zhongliu Zazhi 2000; 22: 466-468
19. Zhou HB, Zhu JR. Paclitaxel induces apoptosis in human gastric carcinoma cells. World J Gastroenterol 2003; 9: 442-445
20. Wu YL, Sun B, Zhang XJ, Wang SN, He HY, Qiao MM, Zhong J, Xu JY. Growth inhibition and apoptosis induction of Sulindac on human gastric cancer cells. World J Gastroenterol 2001; 7: 796-800
21. Hofler H, Becker KF. Molecular mechanisms of carcinogenesis in gastric cancer. Recent Results Cancer Res 2003; 162: 65-72
22. Dixon D, Flake GP, Moore AB, He H, Haseman JK, Risinger JI, Lancaster JM, Berchuck A, Barrett JC, Robboy SJ. Cell proliferation and apoptosis in human uterine leiomyomas and myometria. Virchows Arch 2002; 441: 53-62
23. Wang NS, Unkila MT, Reineks EZ, Distelhorst CW. Transient expression of wild-type or mitochondrially targeted Bcl-2 induces apoptosis, whereas transient expression of endoplasmic eticulum-targeted Bcl-2 is protective against Bax-induced cell death. Biol Chem 2001; 276: 44117-44128
24. Li JQ, Chen RC, Cai KX, Ye ZY. Apoptosis of human gastric cancer cell induced by photochemical riboflavin. Ai Zheng 2003; 22: 253-256
25. Liu S, Wu Q, Ye XF, Cai JH, Huang ZW, Su WJ. Induction of apoptosis by TPA and VP-16 is through translocation of TR3. World J Gastroenterol 2002; 8: 446-450
26. Chen JP, Lin C, Xu CP, Zhang XY, Fu M, Deng YP, Wei T, Wu M. Molecular therapy with recombinant antisense c-myc adenovirus for human gastric carcinoma cells in vitro and in vivo. J Gastroenterol Hepatol 2001; 16: 22-28
27. Liu HL, Lo CR, Jones BE, Pradhan Z, Srinivasan A, Valentino KL, Stockert RJ, Czaja MJ. Inhibition of c-myc expression sensitizes hepatocytes to tumor necrosis factor-induced apoptosis and necrosis. Biol Chem 2000; 275: 40155-40162
28. Zhu GH, Wong BC, Eggo MC, Ching CK, Yuen ST, Chan EY, Lai KC, Lam SK. Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. Br J Cancer 1999; 79: 393-400
29. Ishii HH, Gobe GC, Pan W, Yoneyama J, Ebihara Y. Apoptosis and cell proliferation in the development of gastric carcinomas: Associations with c-myc and p53 protein expression. J Gastroenterol Hepatol 2002; 17: 966-972
30. Tsuji M, Funahashi S, Takigawa M, Seiki M, Fujii K, Yoshida T. Expression of c-fos gene inhibits proteoglycan synthesis in transfected chondrocyte. FEBS Lett 1996; 381: 222-226
31. Ito N, Hirose M, Takahashi S. Cell proliferation and forestomach carcinogenesis. Environ Health Perspect 1993; 101(Suppl 5): 107-110
32. Kane S, Prentice MA, Mariano JM, Cuttitta F, Jakowlew SB. Differential induction of early response genes by adrenomedullin and transforming growth factor-beta1 in human lung cancer cells. Anticancer Res 2002; 22: 1433-1444