Dose response studies: How do we make them conclusive?

Statistics in Medicine

Volumn 18, Issue 6, 1999, Pages 629-641

  Källén, Anders ^a   Larsson, Per ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DOSE RESPONSE; DRUG POTENCY; STATISTICAL ANALYSIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION; HUMANS; PHARMACEUTICAL PREPARATIONS; PHARMACOLOGY;

EID: 0344889078     PISSN: 02776715     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0258(19990330)18:6<629::AID-SIM72>3.0.CO;2-Y     Document Type: Article

References (7)

1. Ruberg, S. L. 'Dose response studies. I. Some design considerations', Journal of Biopharmaceutical Statistics, 5(1), 1-14 (1995).
2. Ruberg, S. L. 'Dose response studies. II. Analysis and interpretation', Journal of Biopharmaceutical Statistics, 5(1), 15-42 (1995).
3. FDC Reports. The Pink Sheets, 53(18), 14-15, (1991).
4. Holford, N. H. G. and Sheiner, L. B. 'Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models', Clinical Pharmacokinetics, 6, 429-453 (1981).
5. Lötvall, J., Lazer, L., Persson, G., Palmqvist, M., Larsson, P., Mardell, M. and Rosenborg, J. 'Formoterol Turbuhaler has a faster onset of action but a similar duration of effect compared with salmeterol Diskhaler at equipotent doses', American Journal of Respiratory and Critical Care Medicine, 153(4:2), A62 (1996).
6. Boorsma, M., Andersson, N., Larsson, P. and Ullman, A. 'Assessment of the relative systemic potency of inhaled fluticasone and budesonide', European Respiratory Journal, 9, 1427-1432 (1996).
7. Davidian, M. and Giltinan, D. M. Nonlinear Models for Repeated Measurement Data, Chapman & Hall, London, 1995.