Human Herpesvirus-8 Latent Nuclear Antigen-1 Expression in Endemic Kaposi Sarcoma: An Immunohistochemical Study of 16 Cases

American Journal of Surgical Pathology

Volumn 27, Issue 12, 2003, Pages 1546-1550

  Schwartz, Erich J ^a   Dorfman, Ronald F ^a   Kohler, Sabine ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diagnosis; Human herpesvirus 8; Immunohistochemistry; Kaposi sarcoma; Latent nuclear antigen

Indexed keywords

CD31 ANTIGEN; CELL NUCLEUS ANTIGEN; LATENT NUCLEAR ANTIGEN 1; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ANTIGEN EXPRESSION; ARTICLE; BIOACCUMULATION; CANCER CLASSIFICATION; CANCER DIAGNOSIS; CONTROLLED STUDY; DISEASE MARKER; ENDEMIC DISEASE; HERPES VIRUS INFECTION; HUMAN; HUMAN HERPESVIRUS 8; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPOSI SARCOMA; NONHUMAN; PROTEIN LOCALIZATION; SOUTH AFRICA; STAINING; VASCULAR LESION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD31; ENDEMIC DISEASES; HERPESVIRUS 8, HUMAN; HUMANS; IMMUNOHISTOCHEMISTRY; NUCLEAR PROTEINS; PHOSPHOPROTEINS; POLYMERASE CHAIN REACTION; SARCOMA, KAPOSI; TUMOR MARKERS, BIOLOGICAL;

EID: 0344861880     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200312000-00007     Document Type: Article

References (22)

1. Boshoff C, Schulz TF, Kennedy MM, et al. Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat Med. 1995;1:1274-8.
2. Cesarman E, Chang Y, Moore PS, et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med. 1995;332:1186-91.
3. Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 1994;266:1865-9.
4. de Lellis L, Fabris M, Cassai E, et al. Herpesvirus-like DNA sequences in non-AIDS Kaposi's sarcoma. J Infect Dis. 1995 Dec;172(6):1605-7.
5. Dorfman RF. Kaposi's sarcoma; the contribution of enzyme histochemistry to the identification of cell types. Acta Union Int Contre Cancer. 1962;18:464-476.
6. Dorfman RF. Kaposi's sarcoma revisited. Hum Pathol. 1984 Nov;15(11):1013-7.
7. Dupin N, Fisher C, Kellam P, et al. Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma. Proc Natl Acad Sci USA. 1999;96:4546-51.
8. Foreman KE, Bacon PE, Hsi ED, et al. In situ polymerase chain reaction-based localization studies support role of human herpesvirus-8 as the cause of two AIDS-related neoplasms: Kaposi's sarcoma and body cavity lymphoma. J Clin Invest. 1997;99:2971-8.
9. Iscovich J, Boffetta P, Franceschi S, et al. Classic Kaposi sarcoma: epidemiology and risk factors. Cancer. 2000;88;3:500-17
10. Jin YT, Tsai ST, Yan JJ, et al. Detection of Kaposi's sarcoma-associated herpesvirus-like DNA sequence in vascular lesions: a reliable diagnostic marker for Kaposi's sarcoma. Am J Clin Pathol. 1996;105:360-3.
11. Kaposi M. Idiopatiches multiples Pigmentsarkom der Haut. Arch Dermatol Syphol. 1872;4:265-72.
12. Katano H, Sato Y, Kurata T, et al. High expression of HHV-8-encoded ORF73 protein in spindle-shaped cells of Kaposi's sarcoma. Am J Pathol. 1999;155:47-52.
13. Katano H, Sato Y, Kurata T, et al. Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's disease. Virology. 2000;269:335-44.
14. Li N, Anderson WK, Bhawan J. Further confirmation of the association of human herpesvirus 8 with Kaposi's sarcoma. J Cutan Pathol. 1998;25:413-9.
15. Li JJ, Huang YQ, Cockerell CJ, et al. Localization of human herpes-like virus type 8 in vascular endothelial cells and perivascular spindle-shaped cells of Kaposi's sarcoma lesions by in situ hybridization. Am J Pathol. 1996;148:1741-8.
16. Nuovo M, Nuovo G. Utility of HHV8 RNA detection for differentiating Kaposi's sarcoma from its mimics. J Cutan Pathol. 2001;28:248-55.
17. Parravicini C, Chandran B, Corbellino M, et al. Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Am J Pathol. 2000;156:743-9.
18. Ryan P, Aarons S, Murray D, et al. Human herpesvirus 8 (HHV-8) detected in two patients with Kaposi's sarcoma-like pyogenic granuloma. J Clin Pathol. 2002;55:619-22.
19. Schalling M, Ekman M, Kaaya EE, et al. A role for a new herpes virus (KSHV) in different forms of Kaposi's sarcoma. Nar Med. 1995;1:707-8.
20. Soulier J, Grollet L, Oksenhendler E, et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood. 1995;86:1276-80.
21. Staskus KA, Sun R, Miller G, et al. Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. J Virol. 1999;73:4181-7.
22. Sturzl M, Blasig C, Schreier A, et al. Expression of HHV-8 latency-associated T0.7 RNA in spindle cells and endothelial cells of AIDS-associated, classical and African Kaposi's sarcoma. Int J Cancer. 1997;72:68-71.