CAY-1, a novel antifungal compound from cayenne pepper

Medical Mycology

Volumn 41, Issue 1, 2003, Pages 75-82

  Renault, S ^a   De Lucca, A J ^b   Boue, S ^b   Bland, J M ^b   Vigo, C B ^b,c   Selitrennikoff, Claude P ^a  

^a MycoLogics Inc   (United States)

^b SOUTHERN REGIONAL RESEARCH CENTER   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Anti fungal drugs; CAY 1; Cayenne pepper; Saponin

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; CAY 1; CILOFUNGIN; MICONAZOLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA KRUSEI; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CELL LINE; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; CYTOTOXICITY; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENTIATION; FUNGAL STRAIN; IN VITRO STUDY; MAMMAL CELL; MINIMUM INHIBITORY CONCENTRATION; NEUROSPORA CRASSA; NONHUMAN; PEPPER;

ANIMALIA; ASPERGILLUS; ASPERGILLUS FUMIGATUS; CANDIDA; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CAPSICUM; CAPSICUM ANNUUM; CAPSICUM FRUTESCENS; CRYPTOCOCCUS NEOFORMANS; FILOBASIDIELLA NEOFORMANS; ISSATCHENKIA ORIENTALIS; MAMMALIA; NEUROSPORA; NEUROSPORA CRASSA;

EID: 0344838521     PISSN: 13693786     EISSN: None     Source Type: Journal    
DOI: 10.1080/mmy.41.1.75.82     Document Type: Article

References (30)

1. Bow EJ. Invasive fungal infections in patients receiving intensive cytotoxic therapy for cancer. Br J Haematol 1998; 101: 1-4.
2. Warnock DW. Fungal infections in neutropenia: Current problems and chemotherapeutic control. J Antimicrob Chemother 1998; 41: 95-105.
3. Alexander BD, Perfect JR. Antifungal resistance trends towards the year 2000. Implications for therapy and new approaches. Drugs 1997; 54: 657-678.
4. Boschman CR, Bodmar UR, Tornatore MA, et al. Thirteen-year evolution of azole resistance in yeast isolates and prevalence of resistant strains carried by cancer patients at a large medical center. Antimicrob Agents Chemother 1998; 42: 734-738.
5. Waller GR, Yamasaki K (eds). Saponins Used in Traditional and Modern Medicine. New York: Plenum Press, 1996.
6. De Lucca AJ, Bland JM, Vigo M, et al. CAY-1, a fungicidal saponin from Capsicum sp. fruit. Med Mycol 2002; 40: 131-137.
7. Vogel HJ. A convenient growth medium for Neurospora. Genet Bull 1956; 13: 42-43.
8. National Committee for Clinical Laboratory Standards. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. Approved Standard M-27A. Wayne, PA: National Committee for Clinical Laboratory Standards, 1997.
9. White RL, Burgess DS, Manduru M, et al. Comparison of three different in vitro methods of detecting synergy: Time-kill, checkerboard and E test. Antimicrob Agents Chemother 1996; 40: 1914-1918.
10. Weinstein RJ, Young LS, Hewitt WL. Comparison of methods for assessing in vitro antibiotic synergism against Pseudomonas and Serratia. J Lab Clin Med 1975; 86: 853-862.
11. Roberts WK, Selitrennikoff CP. Zeamatin, an antifungal protein from maize with membrane-permeabilizing activity. J Gen Microbiol 1990; 136: 1771-1778.
12. Taft CS, Enderlin CS, Selitrennikoff CP. A high throughput in vitro assay for fungal (1,3)β-glucan synthase inhibitors. J Antibiotics 1994; 47: 1001-1009.
13. Wood RL, Miller TK, Wright A, et al. Characterization and optimization of in vitro assay conditions for (1,3)β-glucan synthase activity from Aspergillus fumigatus and Candida albicans for enzyme inhibition screening. J Antibiotics 1998; 51: 665-675.
14. Nakata M, O'Rourke R, Wilson S, et al. A novel assay for fungal ketol-isomerase activity. J Antibiotics 2001; 54: 737-743.
15. Choi WJ, Sburlati A, Cabib E. Chitin synthase 3 from yeast has zymogenic properties that depend on both the CAL1 and the CAL3 genes. Proc Natl Acad Sci 1994; 91: 4727-4730.
16. Barchiesi F, Francesco LF, Compagnucci P, et al. In vitro interaction of terbinafine with amphotericin B, fluconazole and itraconazole against clinical isolates of Candida albicans. J Antimicrob Chemother 1998; 41: 59-65.
17. Ekabo OA, Farnsworth NR, Henderson TO, et al. Antifungal and molluscicidal saponins from Serjania salzmanniana. J Nat Prod 1996; 59: 431-435.
18. Mshvildadze V, Favel A, Delmas F, et al. Antifungal and antiprotozoal activities of saponins from Hedera colchica. Pharmazie 2000; 55: 325-326.
19. Zehavi U, Polacheck I. Saponins as antimycotic agents: Glycosides of medicagenic acid. In: Waller GR, Yamasaki K, eds. Saponins Used in Traditional and Modern Medicine. New York: Plenum Press, 1996: 535-544.
20. Polacheck I, Zehavi U, Naim M, et al. The susceptibility of Cryptococcus neoformans to an antimycotic agent (G2) from alfalfa. Zbl Bakt Hyg 1986; A 261: 481-486.
21. Okunji CO, Iwu MM, Jackson JE, et al. Biological activity of saponins from two Dracaena species. In: Waller GR, Yamasaki K, eds. Saponins Used in Traditional and Modern Medicine. New York: Plenum Press, 1996: 415-428.
22. Polacheck I, Zehavi U, Naim M, et al. Activity of compound G2 isolated from alfalfa roots against medically important yeasts. Antimicrob Agents Chemother 1986; 30: 290-294.
23. 1, in association with pentamidine and amphotericin B. Phytother Res 2001; 15: 298-301.
24. Lalitha T, Venkataraman LV. Antifungal activity and mode of action of saponins from Madhuca butyracea Macb. Ind J Exp Bio 1991; 29: 558-562.
25. Moulin-Traffort J, Favel A, Elias R, et al. Study of the action of α-hederin on the ultrastructure of Candida albicans. Mycoses 1998; 41: 411-416.
26. Polacheck I, Levy M, Guizie M, et al. Mode of action of the antimycotic agent G2 isolated from alfalfa roots. Zbl Bakt 1991; 275: 504-512.
27. Gruiz K. Fungitoxic activity of saponins: Practical use and fundamental principles. In: Waller GR, Yamasaki K, eds. Saponins Used in Traditional and Modern Medicine. New York: Plenum Press, 1996: 527-533.
28. Nakamura T, Inoue K, Nojima S, et al. Interactions of saponins with red blood cell membranes as well as with their phosphatidylcholine liposomal membranes. J Pharmacobiol Dyn 1979; 2: 374.
29. Mimaki Y, Kuroda M, Ide A, et al. Steroidal saponins from the aerial parts of Dracaena draco and their cytostatic activity of HL-60 cells. Phytochemistry 1999; 50: 805-813.
30. Mimaki Y, Kameyama A, Kuroda M, et al. Steroidal glycosides from the underground parts of Hosta plantaginea var. japonica and their cytostatic activity of leukaemia HL-60 cells. Phytochemistry 1997; 44: 305-310.