-
1
-
-
0031911575
-
SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: In vitro anti-inflammatory actions
-
Barnette, M.S., Christensen, S.B., Essayan, D.M., Grous, M., Prabhakar, U., Rush, J.A., Kagey-Sobotka, A. & Torphy, T.J. (1998) SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions. Journal of Pharmacology and Experimental Therapeutics, 284, 420-426.
-
(1998)
Journal of Pharmacology and Experimental Therapeutics
, vol.284
, pp. 420-426
-
-
Barnette, M.S.1
Christensen, S.B.2
Essayan, D.M.3
Grous, M.4
Prabhakar, U.5
Rush, J.A.6
Kagey-Sobotka, A.7
Torphy, T.J.8
-
2
-
-
0028673907
-
Pentoxifylline inhibits mediator synthesis in an equine in vitro whole blood model of endotoxemia
-
Barton, M.H. & Moore, J.N. (1994) Pentoxifylline inhibits mediator synthesis in an equine in vitro whole blood model of endotoxemia. Circulatory Shock, 44, 216-220.
-
(1994)
Circulatory Shock
, vol.44
, pp. 216-220
-
-
Barton, M.H.1
Moore, J.N.2
-
3
-
-
0022491775
-
Release of eicosanoids from white blood cells, platelets, smooth muscle cells, and endothelial cells in response to endotoxin and A23187
-
Bottoms, G.D., Johnson, M., Ward, D., Fessler, J., Lamar, C. & Turek, J. (1986) Release of eicosanoids from white blood cells, platelets, smooth muscle cells, and endothelial cells in response to endotoxin and A23187. Circulatory Shock, 20, 25-34.
-
(1986)
Circulatory Shock
, vol.20
, pp. 25-34
-
-
Bottoms, G.D.1
Johnson, M.2
Ward, D.3
Fessler, J.4
Lamar, C.5
Turek, J.6
-
4
-
-
0035078823
-
In vivo efficacy in airway disease models of roflumilast, a novel orally active PDE4 inhibitor
-
Bundschuh, D.S., Eltze, M., Barsig, J., Wollin, L., Hatzelmann, A. & Beume, R. (2001) In vivo efficacy in airway disease models of roflumilast, a novel orally active PDE4 inhibitor. Journal of Pharmacology and Experimental Therapeutics, 297, 280-290.
-
(2001)
Journal of Pharmacology and Experimental Therapeutics
, vol.297
, pp. 280-290
-
-
Bundschuh, D.S.1
Eltze, M.2
Barsig, J.3
Wollin, L.4
Hatzelmann, A.5
Beume, R.6
-
5
-
-
0001689422
-
Cilomilast (Ariflo®) reduces TNF-a and GM-CSF release by airway cells isolated from COPD patients
-
Chipappara, G., Merendino, A., Chimenti, L., Riccobono, L., Mirabella, F., La Rocca, A., Weck, P., Bonsignore, G. & Vignola, A. (2001) Cilomilast (Ariflo®) reduces TNF-a and GM-CSF release by airway cells isolated from COPD patients. American Journal of Respiratory and Critical Care Medicine, 163, A278.
-
(2001)
American Journal of Respiratory and Critical Care Medicine
, vol.163
-
-
Chipappara, G.1
Merendino, A.2
Chimenti, L.3
Riccobono, L.4
Mirabella, F.5
La Rocca, A.6
Weck, P.7
Bonsignore, G.8
Vignola, A.9
-
6
-
-
0001689418
-
Cilomilast (Ariflo®), a potent, selective inhibitor of phosphodiesterase 4 improves lung function in COPD patients: Results of a 6-month trial
-
Edelson, J., Compton, C., Nieman, R., Robinson, C., Schryver, B., Amit, O., Kelsen, S., Strek, M. & Rennard, S. (2001) Cilomilast (Ariflo ®), a potent, selective inhibitor of phosphodiesterase 4 improves lung function in COPD patients: results of a 6-month trial. American Journal of Respiratory and Critical Care Medicine, 163, A277.
-
(2001)
American Journal of Respiratory and Critical Care Medicine
, vol.163
-
-
Edelson, J.1
Compton, C.2
Nieman, R.3
Robinson, C.4
Schryver, B.5
Amit, O.6
Kelsen, S.7
Strek, M.8
Rennard, S.9
-
7
-
-
0027441715
-
Early neutrophil but not eosinophil or platelet recruitment to the lungs of allergic horses following antigen exposure
-
Fairbairn, S.M., Page, C.P., Lees, P. & Cunningham, F.M. (1993) Early neutrophil but not eosinophil or platelet recruitment to the lungs of allergic horses following antigen exposure. Clinical and Experimental Allergy, 23, 821-828.
-
(1993)
Clinical and Experimental Allergy
, vol.23
, pp. 821-828
-
-
Fairbairn, S.M.1
Page, C.P.2
Lees, P.3
Cunningham, F.M.4
-
8
-
-
0033554272
-
Clinical anti-inflammatory efficacy of arofylline, a new selective phosphodiesterase-4 inhibitor, in dogs with atopic dermatitis
-
Ferrer, L., Alberola, J., Queralt, M., Brazis, P., Rabanal, R., Llenas, J. & Puigdemont, A. (1999) Clinical anti-inflammatory efficacy of arofylline, a new selective phosphodiesterase-4 inhibitor, in dogs with atopic dermatitis. Veterinary Record, 145, 191-194.
-
(1999)
Veterinary Record
, vol.145
, pp. 191-194
-
-
Ferrer, L.1
Alberola, J.2
Queralt, M.3
Brazis, P.4
Rabanal, R.5
Llenas, J.6
Puigdemont, A.7
-
9
-
-
0023059614
-
Endotoxin-induced TxB2 release by polymorphonuclears and macrophages
-
Fiore, S., Reale, M., Alesse, E., Fieschi, C., Di Eugenio, R., Rossi, M., Dempsey, R.A., Altamura, A. & Cifone, M.G. (1986) Endotoxin-induced TxB2 release by polymorphonuclears and macrophages. Bollettino Societa Italiana di Biologia Sperimentale, 62, 737-741.
-
(1986)
Bollettino Societa Italiana di Biologia Sperimentale
, vol.62
, pp. 737-741
-
-
Fiore, S.1
Reale, M.2
Alesse, E.3
Fieschi, C.4
Di Eugenio, R.5
Rossi, M.6
Dempsey, R.A.7
Altamura, A.8
Cifone, M.G.9
-
10
-
-
0035084103
-
Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro
-
Hatzelmann, A. & Schudt, C. (2001) Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro. Journal of Pharmacology and Experimental Therapeutics, 297, 267-279.
-
(2001)
Journal of Pharmacology and Experimental Therapeutics
, vol.297
, pp. 267-279
-
-
Hatzelmann, A.1
Schudt, C.2
-
11
-
-
0020047880
-
Acute pulmonary hypertension and lung thromboxane release after endotoxin infusion in normal and leucopenic sheep
-
Huttemeier, P.C., Watkins, W.D., Peterson, M.B. & Zapol, W.M. (1982) Acute pulmonary hypertension and lung thromboxane release after endotoxin infusion in normal and leucopenic sheep. Circulation Research, 50, 688-694.
-
(1982)
Circulation Research
, vol.50
, pp. 688-694
-
-
Huttemeier, P.C.1
Watkins, W.D.2
Peterson, M.B.3
Zapol, W.M.4
-
12
-
-
0034997852
-
Eicosanoid production by human monocytes: Does COX-2 contribute to a self-limiting inflammatory response?
-
James, M.J., Penglis, P.S., Caughey, G.E., Demasi, M. & Cleland, L.G. (2001) Eicosanoid production by human monocytes: does COX-2 contribute to a self-limiting inflammatory response? Inflammation Research, 50, 249-253.
-
(2001)
Inflammation Research
, vol.50
, pp. 249-253
-
-
James, M.J.1
Penglis, P.S.2
Caughey, G.E.3
Demasi, M.4
Cleland, L.G.5
-
13
-
-
0027944560
-
Endotoxin-induced platelet aggregation in heparinised equine whole blood in vitro
-
Jarvis, G.E. & Evans, R.J. (1994) Endotoxin-induced platelet aggregation in heparinised equine whole blood in vitro. Research in Veterinary Science, 57, 317-324.
-
(1994)
Research in Veterinary Science
, vol.57
, pp. 317-324
-
-
Jarvis, G.E.1
Evans, R.J.2
-
14
-
-
0029898985
-
Platelet-activating factor and not thromboxane A2 is an important mediator of endotoxin-induced platelet aggregation in equine heparinised whole blood in vitro
-
Jarvis, G.E. & Evans, R.J. (1996) Platelet-activating factor and not thromboxane A2 is an important mediator of endotoxin-induced platelet aggregation in equine heparinised whole blood in vitro. Blood Coagulation and Fibrinolysis, 7, 194-198.
-
(1996)
Blood Coagulation and Fibrinolysis
, vol.7
, pp. 194-198
-
-
Jarvis, G.E.1
Evans, R.J.2
-
15
-
-
0033154563
-
Effect of exercise and COPD crisis on isoprostane concentration in plasma and bronchoalveolar lavage fluid in horses
-
Kirschvink, N., Art, T., Smith, N. & Lekeux, P. (1999) Effect of exercise and COPD crisis on isoprostane concentration in plasma and bronchoalveolar lavage fluid in horses. Equine Veterinary Journal, 30(Suppl.), 88-91.
-
(1999)
Equine Veterinary Journal
, vol.30
, Issue.SUPPL.
, pp. 88-91
-
-
Kirschvink, N.1
Art, T.2
Smith, N.3
Lekeux, P.4
-
16
-
-
0001183327
-
The measurement of interpleural pressure - A method to assess lung mechanics in the horse
-
Klein, H.-J. & Deegen, E. (1987) The measurement of interpleural pressure - a method to assess lung mechanics in the horse. Pferdeheilkunde, 3, 141-147.
-
(1987)
Pferdeheilkunde
, vol.3
, pp. 141-147
-
-
Klein, H.-J.1
Deegen, E.2
-
17
-
-
0023405909
-
Serum thromboxane in the horse and its inhibition by aspirin, phenylbutazone and flunixin
-
Lees, P., Ewins, C.P., Taylor, J.B. & Sedgwick, A.D. (1987) Serum thromboxane in the horse and its inhibition by aspirin, phenylbutazone and flunixin. British Veterinary Journal, 143, 462-476.
-
(1987)
British Veterinary Journal
, vol.143
, pp. 462-476
-
-
Lees, P.1
Ewins, C.P.2
Taylor, J.B.3
Sedgwick, A.D.4
-
18
-
-
0034424517
-
Chronic obstructive pulmonary disease: A review
-
Mair, T.S. & Derksen, F.J. (2000) Chronic obstructive pulmonary disease: a review. Equine Veterinary Education, 12, 35-44.
-
(2000)
Equine Veterinary Education
, vol.12
, pp. 35-44
-
-
Mair, T.S.1
Derksen, F.J.2
-
19
-
-
0029841921
-
Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophils stimulated with various agonists
-
Nahas, N., Molski, T.F., Fernandez, C.A. & Sha'afi, R.I. (1996) Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophils stimulated with various agonists. Biochemical Journal, 318, 247-253.
-
(1996)
Biochemical Journal
, vol.318
, pp. 247-253
-
-
Nahas, N.1
Molski, T.F.2
Fernandez, C.A.3
Sha'afi, R.I.4
-
20
-
-
0026615111
-
2+ signaling via platelet-activating factor receptor
-
2+ signaling via platelet-activating factor receptor. Federation of European Biochemical Societies Letters, 314, 125-129.
-
(1992)
Federation of European Biochemical Societies Letters
, vol.314
, pp. 125-129
-
-
Nakamura, M.1
Honda, Z.2
Waga, I.3
Matsumoto, T.4
Noma, M.5
Shimizu, T.6
-
21
-
-
0029587485
-
2, D but not C
-
2, D but not C. Comparative Biochemical Physiology, 112C, 137-143.
-
(1995)
Comparative Biochemical Physiology
, vol.112 C
, pp. 137-143
-
-
Nakashima, S.1
Mizutani, T.2
Nakamura, Y.3
Takemura, S.O.4
Nakamura, M.5
Miyata, H.6
Katagiri, Y.7
Nozawa, Y.8
-
22
-
-
0000021687
-
Inhibitors of cyclic nucleotide phosphodiesterase isoenzymes - Their potential utility in the therapy of asthma
-
Nicholson, C.D. & Shahid, M. (1993) Inhibitors of cyclic nucleotide phosphodiesterase isoenzymes - their potential utility in the therapy of asthma. Pulmonary Pharmacology, 6, 101-117.
-
(1993)
Pulmonary Pharmacology
, vol.6
, pp. 101-117
-
-
Nicholson, C.D.1
Shahid, M.2
-
23
-
-
0001113345
-
Production of free oxygen radicals by phagocytes from respiratory tract lavaged as well as from peripheral blood of horses with chronic obstructive pulmonary disease (COPD) in comparison to healthy animals
-
Olszewski, M.A. & Laber, G. (1993) Production of free oxygen radicals by phagocytes from respiratory tract lavaged as well as from peripheral blood of horses with chronic obstructive pulmonary disease (COPD) in comparison to healthy animals. Wiener Tierarztliche Monatsschrift, 80, 332-337.
-
(1993)
Wiener Tierarztliche Monatsschrift
, vol.80
, pp. 332-337
-
-
Olszewski, M.A.1
Laber, G.2
-
24
-
-
0035292798
-
MMP-9 as a marker of inflammation in tracheal epithelial lining fluid (TELF) and in bronchoalveolar fluid (BALD of COPD horses
-
Raulo, S.M., Sorsa, T., Tervahartiala, T., Pirila, E. & Maisi, P. (2001) MMP-9 as a marker of inflammation in tracheal epithelial lining fluid (TELF) and in bronchoalveolar fluid (BALD of COPD horses, Equine Veterinary Journal, 33, 128-136.
-
(2001)
Equine Veterinary Journal
, vol.33
, pp. 128-136
-
-
Raulo, S.M.1
Sorsa, T.2
Tervahartiala, T.3
Pirila, E.4
Maisi, P.5
-
25
-
-
0034872859
-
Differential inhibition of equine neutrophil function by phosphodiesterase inhibitors
-
Rickards, K.J., Page, C.P., Lees, P. & Cunningham, F.M. (2001) Differential inhibition of equine neutrophil function by phosphodiesterase inhibitors. Journal of Veterinary Pharmacology and Therapeutics, 24, 275-281.
-
(2001)
Journal of Veterinary Pharmacology and Therapeutics
, vol.24
, pp. 275-281
-
-
Rickards, K.J.1
Page, C.P.2
Lees, P.3
Cunningham, F.M.4
-
26
-
-
0026354677
-
Influence of selective phosphodiesterase inhibitors on human neutrophil functions and levels of cAMP and Cai
-
Schudt, C., Winder, S., Forderkunz, S., Hatzelmann, A. & Ulrich, V. (1991) Influence of selective phosphodiesterase inhibitors on human neutrophil functions and levels of cAMP and Cai. Naunyn Schmiedebergs Archives of Pharmacology, 344, 682-690.
-
(1991)
Naunyn Schmiedebergs Archives of Pharmacology
, vol.344
, pp. 682-690
-
-
Schudt, C.1
Winder, S.2
Forderkunz, S.3
Hatzelmann, A.4
Ulrich, V.5
-
27
-
-
0028538344
-
Effect of prior lavage on bronchoalveolar lavage fluid cell population of lavaged and unlavaged lung segments in horses
-
Sweeney, C.R., Rossier, Y., Ziemer, E.L. & Lindborg, S.R. (1994) Effect of prior lavage on bronchoalveolar lavage fluid cell population of lavaged and unlavaged lung segments in horses. American Journal of Veterinary Research, 55, 1501-1504.
-
(1994)
American Journal of Veterinary Research
, vol.55
, pp. 1501-1504
-
-
Sweeney, C.R.1
Rossier, Y.2
Ziemer, E.L.3
Lindborg, S.R.4
-
28
-
-
0033106501
-
Ariflo (SB 207499), a second generation phosphodiesterase 4 inhibitor for the treatment of asthma and COPD: From concept to clinic
-
Torphy, T.J., Barnette, M.S., Underwood, D.C., Griswold, D.E., Christensen, S.B., Murdoch, R.D., Nieman, R.B. & Compton, C.H. (1999) Ariflo (SB 207499), a second generation phosphodiesterase 4 inhibitor for the treatment of asthma and COPD: from concept to clinic. Pulmonary Pharmacology and Therapeutics, 12, 131-135.
-
(1999)
Pulmonary Pharmacology and Therapeutics
, vol.12
, pp. 131-135
-
-
Torphy, T.J.1
Barnette, M.S.2
Underwood, D.C.3
Griswold, D.E.4
Christensen, S.B.5
Murdoch, R.D.6
Nieman, R.B.7
Compton, C.H.8
-
29
-
-
0031473317
-
Attenuation by phosphodiesterase inhibitors of lipopolysaccharide-induced thromboxane release and bronchoconstriction in rat lungs
-
Uhlig, S., Featherstone, R.L., Held, H.D., Nusing, R., Schudt, C. & Wendel, A. (1997) Attenuation by phosphodiesterase inhibitors of lipopolysaccharide-induced thromboxane release and bronchoconstriction in rat lungs. Journal of Pharmacology and Experimental Therapeutics, 283, 1453-1459.
-
(1997)
Journal of Pharmacology and Experimental Therapeutics
, vol.283
, pp. 1453-1459
-
-
Uhlig, S.1
Featherstone, R.L.2
Held, H.D.3
Nusing, R.4
Schudt, C.5
Wendel, A.6
-
30
-
-
0000091543
-
Ariflo (SB 207499) inhibits airway neutrophilia, inflammatory cytokine production and matrix metalloproteinase-9 activity in the guinea pig
-
Underwood, D.C., Oshorn, R.R., Bochnowicz, S., Rieman, D.J., Romanic, A.M., Hay, D.W.P., Griswold, D.E. & Torphy, T.J. (2000) Ariflo (SB 207499) inhibits airway neutrophilia, inflammatory cytokine production and matrix metalloproteinase-9 activity in the guinea pig. American Journal of Respiratory and Critical Care Medicine, 161, A492.
-
(2000)
American Journal of Respiratory and Critical Care Medicine
, vol.161
-
-
Underwood, D.C.1
Oshorn, R.R.2
Bochnowicz, S.3
Rieman, D.J.4
Romanic, A.M.5
Hay, D.W.P.6
Griswold, D.E.7
Torphy, T.J.8
-
31
-
-
0026659881
-
Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages
-
Weinstein, S.L., Sanghera, J.S., Lemke, K., DeFranco, A.L. & Pelech, S.L. (1992) Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages. Journal of Biological Chemistry, 267, 14955-14962.
-
(1992)
Journal of Biological Chemistry
, vol.267
, pp. 14955-14962
-
-
Weinstein, S.L.1
Sanghera, J.S.2
Lemke, K.3
DeFranco, A.L.4
Pelech, S.L.5
-
32
-
-
0029953233
-
Human whole blood assays for inhibition of prostaglandin G/H synthases-1 and -2 using A23187 and lipopolysaccharide stimulation of thromboxane B2 production
-
Young, J.M., Panah, S., Satchawatcharaphong, C. & Cheung, P.S. (1996) Human whole blood assays for inhibition of prostaglandin G/H synthases-1 and -2 using A23187 and lipopolysaccharide stimulation of thromboxane B2 production. Inflammation Research, 45, 246-253.
-
(1996)
Inflammation Research
, vol.45
, pp. 246-253
-
-
Young, J.M.1
Panah, S.2
Satchawatcharaphong, C.3
Cheung, P.S.4
-
33
-
-
0033583034
-
Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes
-
Zhang, F.X., Kirschning, C.J., Mancinelli, R., Xu, X.P., Jin, Y., Faure, E., Mantovani, A., Rothe, M., Muzio, M. & Arditi, M. (1999) Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. Journal of Biological Chemistry, 274, 7611-7614.
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 7611-7614
-
-
Zhang, F.X.1
Kirschning, C.J.2
Mancinelli, R.3
Xu, X.P.4
Jin, Y.5
Faure, E.6
Mantovani, A.7
Rothe, M.8
Muzio, M.9
Arditi, M.10
-
34
-
-
0026021037
-
Attenuation of LPS-induced neutrophil thromboxane b2 release and chemiluminescence
-
Zheng, H., Crowley, J.J., Chan, J.C. & Raffin, T.A. (1991) Attenuation of LPS-induced neutrophil thromboxane b2 release and chemiluminescence. Journal of Cell Physiology, 146, 264-269.
-
(1991)
Journal of Cell Physiology
, vol.146
, pp. 264-269
-
-
Zheng, H.1
Crowley, J.J.2
Chan, J.C.3
Raffin, T.A.4
|