Developing VDEPT for DT-diaphorase (NQO1) using an AAV vector plasmid

International Journal of Radiation Oncology Biology Physics

Volumn 42, Issue 4, 1998, Pages 909-912

  Warrington Jr , Kenneth H ^a   Teschendorf, Christian ^a   Cao, Longguang ^a   Muzyczka, Nicholas ^a   Siemann, Dietmar W ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

AAV; Bioreductive drugs; NQO1; Virally directed enzyme prodrug therapy

Indexed keywords

PRODRUG; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCING AGENT; VIRUS VECTOR;

CONFERENCE PAPER; GENE THERAPY; HUMAN; HUMAN CELL; OVARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; SARCOMA;

ANIMALS; DEPENDOVIRUS; FEMALE; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; INDICATORS AND REAGENTS; LUMINESCENT PROTEINS; MICE; NAD(P)H DEHYDROGENASE (QUINONE); OVARIAN NEOPLASMS; SARCOMA, EXPERIMENTAL; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0344835944     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(98)00357-5     Document Type: Conference Paper

References (9)

1. Moolten F.L. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes Paradigm for a prospective cancer control strategy . Cancer Res. 46:1986;5276-5281.
2. Wei M.X., Tamiya T., Chase M., et al. Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene. Hum Gene Ther. 5:1994;969-978.
3. Gustafson D.L., Beall H.D., Bolton E.M., et al. Expression of human NAD(P)H:Quinone oxidoreductase (DT-Diaphorase) in Chinese hamster ovary cells Effect on the toxicity of antitumor quinones . Mol Pharmacol. 50:1996;728-735.
4. Roth J.A., Cristiano R.J. Gene therapy for cancer What have we done and where are we going? J Natl Cancer Inst. 89:1997;21-39.
5. Muzyczka N. Use of adeno-associated virus as a general transduction vector for mammalian cells. Curr Top Microbiol Immunol. 158:1992;97-129.
6. Kain S.R., Adams M., Kondepudi A., et al. Green fluorescent protein as a reporter of gene expression and protein localization. Biotechniques. 19:1995;650-655.
7. Zolotukhin S., Potter M., Hausurth W.W., et al. A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells. J Virol. 70:1996;4646-4654.
8. Berns K.I., Linden R.M. The cryptic life style of adeno-associated virus. Bioessays. 17:1994;237-245.
9. Smitskamp-Wilms E., Hendriks H.R., Peters G.J. Development, pharmacology, role of DT-diaphorase and prospects of the indoloquinone EO9. Gen Pharmacol. 27:1996;421-429.