Release of indomethacin from pH-sensitive pullulan acetate microsphere

Biotechnology and Bioprocess Engineering

Volumn 2, Issue 1, 1997, Pages 48-52

  Na, Kun ^a   Jeong, Young Il ^a   Lee, Ki Young ^a  

^a Chonnam National University   (South Korea)

Author keywords

Indomethacin; pH sensitive IND release; Pullulan acetate microsphere

Indexed keywords

EID: 0344813091     PISSN: 12268372     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02932463     Document Type: Article

References (16)

1. Langer, R. (1990) New methods of drug delivery, Science, 249: 1527-1533.
2. Hoffman, A. S., A. Afrassiabi, and A. C. Dong (1986) Thermally reversible hydrogels: II. Delivery and selective release of substances from aqueous solution. J. Control. Release 4: 213-222.
3. Siegel, R. A. and B. A. Firestone (1988) pH-dependent equilibrium swelling properties of hydrophobic polyelectrolyte copolymer gels. Macromolecules 21: 3254-3259.
4. Kwon, I. C., Y. H. Bae, T. Okano, B. Berner, and S. W. Kim (1990) Stimuli sensitive polymers for drug delivery systems, Macromol. Chem. Macro. Symp. 33: 265-277.
5. Kuhn, W., B. Haritary, A. Katchalsky, and H. Eisenberg (1950) Reversible dilation and contraction by changing the state of ionization of high-polymer acid network, Nature 165: 414-418.
6. Dong, L., Q. Yan, and A. S. Hoffman (1994) Controlled release of amylase from thermal and pH-sensitive, macroporous hydrogel, J. Control. Release 28: 143-152.
7. Sugawara, S., T. Imai, and M. Otagiri (1994) The controlled release of prednisolone using alginate gel, Pharm. Res. 11: 272-277.
8. Yuk, S. H., S. H. Cho, and H. B. Lee (1995) pH-sensitive drug delivery system using O/W emulsion, J. Control. Release 37: 69-74.
9. Laakso, R. and K. Paulamaki (1984) Release of IND from ethyl cellulose film- coating granules and multiple unit tablets, Acta Pharm. Fenn. 93: 193-200.
10. Santucci, E., F. Alhaique, M. Carafa, T. Coviello, E. Murtas, and F. M. Riccieri (1996) Gellan for the formulation of sustained delivery beads, J. Control. Release 42: 157-164.
11. Catley, B. J. (1972) Pullulan elaboration, an inducible system of Pullularia pullulans, FEBS Lett. 20: 174-176.
12. Zajic J. E. and A. LeDuy (1973) Flocculant and chemical properties of a polysaccharide from Pullularia pullulans. Appl. Microbial. 25: 628-635.
13. LeDuy, A. and J. J. Yarmoff (1983) Enhanced production of pullulan from lactose by adaptation and by mixed culture techniques. Biotechnol. Lett. 5: 49-54.
14. Motozato, Y., H. Ihara, T. Tomoda, and C. Hirayama (1986) Preperation and gel permeation chromatographic properties of pullulan sphere. J. Chromatography 355: 434-437.
15. Conn, E. E. and P. K. Stumpf (1979) Outlines of Biochemistry. John Wiley and Sons IND 4: 79.
16. La, S. B., Okano, T. and K. Kataoka (1996) Preparation and characterization of the micelle-forming polymeric drug indomethacin-incorporated poly(ethylene oxide)-poly(β-benzyl L-aspartate) block copolymer micelles, J. Pharm. Sci. 85: 85-90.