Total Synthesis of Lactonamycinone

Angewandte Chemie - International Edition

Volumn 42, Issue 45, 2003, Pages 5629-5634

  Siu, Tony ^a   Cox, Christopher D ^a   Danishefsky, Samuel J ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Antibiotics; Diels Alder reaction; Natural products; Quinones; Total synthesis

Indexed keywords

HYDROXYLATION; SYNTHESIS (CHEMICAL);

ACID-INDUCED KETALIZATION;

AROMATIC COMPOUNDS;

ANTIBIOTIC AGENT; FURANONE DERIVATIVE; KETOQUINONE; LACTONAMYCINONE; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLIZATION; DIHYDROXYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

BENZOQUINONES; CRYSTALLOGRAPHY, X-RAY; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NAPHTHOQUINONES;

EID: 0344792636     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200352592     Document Type: Article

References (16)

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16. The spectra of lactonamycin and its aglycone are quite similar, except for the protons from the glycoside and one of the protons at C5, whose signal differs by 0.2 ppm presumably due to the perturbation of the glycoside.