Protein kinase C-mediated phosphorylation and desensitization of human α(1b)-adrenoceptors

European Journal of Pharmacology

Volumn 385, Issue 2-3, 1999, Pages 263-271

  García Sáinz, J Adolfo ^a   Gottfried Blackmore, Andrés ^a   Vázquez Prado, José ^a   Romero Avila, Ma Teresa ^a  

^a INSTITUTO DE FISIOLOGÍA CELULAR   (Mexico)

Author keywords

Desensitization; Phosphorylation; 1 Adrenoceptor

Indexed keywords

5 METHYLURAPIDIL; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ALPHA 1 ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; NORADRENALIN; PHENTOLAMINE; PRAZOSIN; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION;

EID: 0344771109     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00629-9     Document Type: Article

References (38)

1. Benovic J.L., DeBlasi A., Stone W.C., Caron M.G., Lefkowitz R.J. β-Adrenergic receptor kinase: primary structure delineates a multigene family. Science. 246:1990;235-240.
2. Berridge M.J., Dawson R.M.C., Downes P., Heslop J.P., Irvine R.F. Changes in the level of inositol phosphates after agonist-dependent hydrolysis of membrane phospholipids. Biochem. J. 212:1983;473-482.
3. Cheng Y.-C., Prusoff W.H. Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 percent inhibition of an enzymatic reaction. Biochem. Pharmacol. 22:1973;3099-3108.
4. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
5. Clark R.B., Kunkel M.W., Friedman J., Goka T.J., Johnson J.A. Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells. Proc. Natl. Acad. Sci. U.S.A. 85:1988;1442-1446.
6. 1-adrenergic regulation of hepatocyte metabolism. Biochem. Biophys. Res. Commun. 119:1984;1128-1133.
7. 1-adrenoceptors for epinephrine. J. Biol. Chem. 261:1986;520-526.
8. 1-adrenergic receptor. Proc. Natl. Acad. Sci. U.S.A. 85:1988;7159-7163.
9. 1B-adrenergic receptor. J. Biol. Chem. 271:1996;5049-5058.
10. 1B-adrenergic receptor. J. Biol. Chem. 272:1997;28712-28719.
11. Ferguson S., Zhang J., Barak L.S., Caron M.G. Pleiotrophic role for GRKs and β-arrestins in receptor regulation. News Physiol. Sci. 12:1997;145-151.
12. 1C subtype. Mol. Pharmacol. 45:1994;703-708.
13. García-Sáinz J.A. Modulation of cell responsiveness by protein kinase C: receptors, G proteins and membrane effectors. News Physiol. Sci. 6:1991;169-173.
14. 1-adrenoceptors. Subtypes, signal transduction and regulation. Pharmacol. Commun. 6:1995;53-60.
15. 1A subtype. Eur. J. Pharmacol. 289:1995;81-86.
16. 1-Adrenoceptor subtype activation increases proto-oncogene mRNA levels. Role of protein kinase C. Eur. J. Pharmacol. 342:1998;311-317.
17. 1-Adrenergic receptor subtypes. Molecular structure, function and signalling. Circ. Res. 78:1996;737-749.
18. 2-adrenergic receptors in response to insulin. J. Biol. Chem. 267:1992;26017-26022.
19. 1-adrenoceptors: consensus update. Pharmacol. Rev. 47:1995;267-270.
20. Houslay M.D. Crosstalk: a pivotal role for protein kinase C in modulating relationships between signal transduction pathways. Eur. J. Biochem. 195:1991;9-27.
21. 2-adrenergic receptor in vivo on sites distinct from those phosphorylated in response to insulin. J. Biol. Chem. 271:1996;29347-29352.
22. Karoor V., Baltensperger K., Paul H., Czeck M.P., Malbon C.C. Phosphorylation of tyrosyl residues 350/354 of the β-adrenergic receptor is obligatory for counterregulatory effects of insulin. J. Biol. Chem. 270:1995;25305-25308.
23. 1B-adrenergic receptor. J. Biol. Chem. 269:1994;22887-22893.
24. 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism. Proc. Natl. Acad. Sci. U.S.A. 82:1985;5651-5655.
25. 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit. J. Biol. Chem. 261:1986;7710-7716.
26. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
27. 2+ signalling by v-src transformation in rat-1 fibroblast. J. Biol. Chem. 267:1992;7470-7477.
28. 1b-adrenoceptors induced through activation of bradykinin B2 receptors. FEBS Lett. 422:1998;141-145.
29. 1-Adrenergic receptors subtypes. Annu. Rev. Pharmacol. Toxicol. 34:1994;117-133.
30. Premont R.T., Inglese J., Lefkowitz R.J. Protein kinases that phosphorylate activated G protein-coupled receptors. FASEB J. 9:1995;175-183.
31. 1-adrenergic receptor subtypes in human tissues: implications for human adrenergic physiology. Mol. Pharmacol. 45:1994;171-175.
32. Rodriguez-Peña A., Rozengurt E. Disappearance of Ca-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells. Biochem. Biophys. Res. Commun. 120:1984;1053-1059.
33. 1-adrenergic receptor by complex type N-linked oligosaccharides. Mol. Pharmacol. 32:1987;565-571.
34. 1-adrenergic receptors: sequence corrections and direct comparison with other species homologues. J. Pharmacol. Exp. Ther. 272:1995;134-142.
35. 1-adrenoceptor subtypes. Mol. Pharmacol. 50:1996;17-22.
36. 1b-adrenoceptors in rat-1 fibroblasts. J. Biol. Chem. 272:1997;27330-27337.
37. 1C. Biochem. Biophys. Res. Commun. 201:1994;1296-1304.
38. Wieland T., Jakobs K.H. Measurements of receptor-stimulated guanosine 5′-O-(gama-thio)triphosphate binding by G proteins. Iyengar R. Methods in Enzymology. 237:1994;3-13 Academic Press, London.