Antitumour efficacy of cyclodextrin-complexed and niosome-encapsulated plumbagin in mice bearing melanoma B16F1

Pharmacy and Pharmacology Communications

Volumn 5, Issue 4, 1999, Pages 281-285

  Oommen, Elsie ^b   Shenoy, B Dinesh ^b   Udupa, N ^b   Kamath, Ravindra ^a   Uma Devi, P ^a  

^a KASTURBA MEDICAL COLLEGE   (India)

^b MANIPAL COLLEGE OF PHARMACEUTICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CYCLODEXTRIN; DICETYL PHOSPHATE; NIOSOME; PLUMBAGIN; SORBITAN STEARATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; ENCAPSULATION; FEMALE; HYDRATION; MALE; MELANOMA; MOUSE; NONHUMAN; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0344758435     PISSN: 14608081     EISSN: None     Source Type: Journal    
DOI: 10.1211/146080899128734857     Document Type: Article

References (23)

1. Anguiano-Igea, S., Otero-Espinar, F. J., Vila-Jato, J. L., Blanco-Mendez, J. (1996) Improvement of clofibrate dissolution by complexation with cyclodextrin. Int. J. Pharm. 135: 161-166
2. Azmin, M. N., Florence, A. T., Handjani-Vila, R. M., Stewert, J. F., Vanlerberghe, G., Whittaker, J. S. (1985) The effect of non-ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice. J. Pharm. Pharmacol. 37: 237-242
3. Baillie, A. J., Florence, A. T., Hume, L. R., Muirhead, G. T., Rogerson, A. (1985) The preparation and properties of niosomes - non-ionic surfactant vesicles. J. Pharm. Pharmacol. 37: 863-868
4. Bootsma, H. P. R., Frijlink, H. W., Eissens, A., Proost, J. H., Van Diirne, H., Lerk, C. F. (1989) β-Cyclodextrin as an excipient in solid oral dosage forms: in-vitro and in-vivo evaluation of spray-dried diazepam-betacyclodextrin products. Int. J. Pharm. 51: 213-223
5. D'Souza, R. A., Singh, U. V., Aithal, K. S., Udupa, N. (1997a) Antifertility activity of niosomal HPβCD-plumbagin complex. Indian J. Pharm. Sci. 60: 36-40
6. D'Souza, S. A., Ray, J., Pandey, S., Udupa, N. (1997b) Absoption of ciprofloxacin and norfloxacin when administered as niosome-encapsulated inclusion complexes. J. Pharm. Pharmacol. 49: 145-149
7. Gabizon, A. A., Papahadjopoulos, D. (1988) Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumours. Proc. Natl Acad. Sci. USA 85: 6949-6953
8. Harashima, H., Sakata K., Funato, K., Kiwada, H. (1994) Enhanced hepatic uptake of liposomes through complement activation depending on the size of liposomes. Pharm. Res. 11: 402-406
9. Jarho, P., Urtti, A., Pate, D. W., Suhonen, P., Jarvinen, T. (1996) Increase in aqueous solubility, stability and in-vitro corneal permeability of anadamide by hydroxypropyl-β-cyclodextrin. Int. J. Pharm. 137: 209-216
10. Kini, D. P., Pandey, S., Shenoy, B. D., Singh, U. V., Udupa, N., Nagaraj, K., Kamath, R., Uma Devi, P., Ramnarayana, K. (1997) Anti-tumor and anti-fertility activities of plumbagin controlled release formulations. Indian J. Exp. Biol. 35: 374-379
11. Krishnaswamy, M., Purushothaman, K. K. (1980) Plumbagin. A study of its anticancer, antibacterial and antifungal properties. Indian J. Exp. Biol. 18: 876-877
12. McCormack, B., Greogoriadis, G. (1994) Drugs-in-cyclodextrin-in-liposomes a novel concept in drug delivery. Int. J. Pharm. 112: 249-258
13. Muller, B. W., Albers, E. (1992) Complexation of dihydropyridine derivatives with cyclodextrin and 2-hydroxyproyl-β-cyclodextrin in solution. Int. J. Pharm. 79: 273-289
14. Rahman, A., White, G., More, N., Schein, P. S. (1985) Pharmacological, toxicological and therapeutic evaluation in mice of doxorubicin entrapped in cardiolipin liposomes. Cancer Res. 45: 796-803
15. Raja Naresh, R. A., Udupa, N., Uma Devi, P. (1996) Niosomal plumbagin with reduced toxicity and improved anticancer activity in Balb/C mice. J. Pharm. Pharmacol. 48: 1128-1132
16. Santhakumari, G., Saralamma, P. G., Radhakrishnan, N. (1980) Effect of plumbagin on cell growth and mitosis. Indian J. Exp. Biol. 18: 215-219
17. Sheena, I. P., Singh, U. V., Aithal, K. S., Udupa, N. (1997a) Niosomal entrapment of hydroxypropyl-β-cyclodextrin-methotrexate complex as a drug delivery system. Pharm. Sci. 3: 579-582
18. Sheena, I. P. Singh, U. V., Aithal, K. S., Udupa, N. (1997b) Pilocarpine-β-cyclodextrin complexation and niosomal entrapment. Pharm. Sci. 3: 383-386
19. Singh, U. V., Udupa, N. (1997) Reduced toxicity and enhanced antitumor efficacy of betacyclodextrin plumbagin inclusion complex in mice bearing Ehrlich ascites carcinoma. Indian J. Physiol. Pharmacol. 41: 171-175
20. Singh, U. V., Bisht, K. S., Rao, S., Uma Devi, P., Udupa, N. (1996) Plumbagin-loaded PLGA microspheres with reduced toxicity and enhanced antitumor efficacy in mice. Pharm. Sci. 2: 407-409
21. Singh, U. V., Aithal, K. S., Udupa, N. (1997) Physicochemical and biological studies of inclusion complex of methotrexate with β-cyclodextrin. Pharm. Sci. 3: 573-577
22. Singh, U. V., Aithal, K. S., Udupa, N. (1998) Inclusion complex of plumbagin with betacyclodextrin as evidenced by spectral data and molecular modelling. Pharmazie. 53: 208-210
23. Uma Devi, P., Rao, B. S. S. (1993) Response of mouse sarcoma-180 to bleomycin in combination with radiation and hyperthermia. Strahlenther. Onkol. 169: 601-607