Association study between corticotrophin-releasing hormone genomic region (8q13) and rheumatoid arthritis in the Spanish population

Rheumatology

Volumn 42, Issue 12, 2003, Pages 1534-1538

  Julia A ^b   Gallardo, D ^a   Vidal, F ^a   De Agustin J J ^b   Barcelo P ^b   Villardell, M ^b   Marsal, Sara ^b  

^a ICS   (Spain)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

Association; CRH; Microsatellite; Rheumatoid Arthritis; Susceptibility; Transmission Disequilibrium Test

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; MICROSATELLITE DNA;

ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DNA POLYMORPHISM; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; PATHOGENESIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SPAIN; STATISTICAL SIGNIFICANCE; UNITED KINGDOM;

ARTHRITIS, RHEUMATOID; CHROMOSOMES, HUMAN, PAIR 8; CORTICOTROPIN-RELEASING HORMONE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; MICROSATELLITE REPEATS; PEDIGREE; POLYMERASE CHAIN REACTION; SPAIN;

EID: 0344668702     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/keg423     Document Type: Article

References (30)

1. Silman AJ, MacGregor AJ, Thomson W et al. Twin concordance rates for rheumatoid arthritis: results from a nationwide study. Br J Rheumatol 1993;32:903-7.
2. Aho K, Koskenvuo M, Tuominen J, Kaprio J. Occurrence of rheumatoid arthritis in a nationwide series of twins. J Rheumatol 1986;13:899-902.
3. Deighton CM, Walker DJ. The familial nature of rheumatoid arthritis. Ann Rheum Dis 1991;50:62-5.
4. MacGregor AJ, Snieder H, Rigby AS et al. Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum 2000;43:30-7.
5. Cornelis F, Faure S, Martinez M et al. New susceptibility locus for rheumatoid arthritis suggested by a genomewide linkage study. Proc Natl Acad Sci USA 1998;95: 10746-50.
6. John S, Eyre S, Myerscough A et al. Linkage and association analysis of candidate genes in rheumatoid arthritis. J Rheumatol 2001;28:1752-5.
7. Shiozawa S, Hayashi S, Tsukamoto Y et al. Identification of the gene loci that predispose to rheumatoid arthritis. Int Immunol 1998;10:1891-5.
8. Jawaheer D, Seldin M, Amos C et al. A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases. Am J Hum Genet 2001;68:927-36.
9. MacKay K, Eyre S, Myerscough A et al. Whole-genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in the United Kingdom. Arthritis Rheum 2002;46:632-9.
10. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995;11:241-7.
11. Cox A, Camp NJ, Cannings C et al. Combined sib-TDT and TDT provide evidence for linkage of the interleukin-1 gene cluster to erosive rheumatoid arthritis. Hum Mol Genet 1999;8:1707-13.
12. Fife MS, Fisher SA, John S et al. Multipoint linkage analysis of a candidate gene locus in rheumatoid arthritis demonstrates significant evidence of linkage and association with the corticotropin-releasing hormone genomic region. Arthritis Rheum 2000;43:1673-8.
13. Fife M, Steer S, Fisher S et al. Association of familial and sporadic rheumatoid arthritis with a single corticotropin-releasing hormone genomic region (8q12.3) haplotype. Arthritis Rheum 2002;46:75-82.
14. Sternberg EM, Hill JM, Chrousos GP et al. Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats. Proc Natl Acad Sci USA 1989;86:2374-8.
15. Chikanza IC, Petrou P, Kingsley G, Chrousos G, Panayi GS. Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis. Arthritis Rheum 1992;35:1281-8.
16. Kassimos D, Choy EH, Grossman AB, Chikanza IC, Panayi GS. Endogenous opioid tone in patients with rheumatoid arthritis. Br J Rheumatol 1996;35:436-40.
17. Arnett FC, Edworthy SM, Bloch DA et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
18. Schneider S, Roessli D, Excoffier L. Arlequin ver. 2.000: A software for population genetics data analysis. Geneva, 2000.
19. Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993;52:506-16.
20. Clayton D, Jones H. Transmission/disequilibrium tests for extended marker haplotypes. Am J Hum Genet 1999;65:1161-9.
21. Schlotterer C, Tautz D. Slippage synthesis of simple sequence DNA. Nucleic Acids Res 1992;20:211-5.
22. Knapp M. A note on power approximations for the transmission/disequilibrium test. Am J Hum Genet 1999;64:1177-85.
23. Yelamos J, Garcia Lozano JR, Moreno I et al. Association of HLA-DR4-Dw15 (DRB1*0405) and DR10 with rheumatoid arthritis in a Spanish population. Arthritis Rheum 1993;36:811-4.
24. Lanchbury JS, Schork NJ. Peaks and troughs in linkage mapping for the rheumatic diseases. 2000;39:453-6.
25. Kruglyak L. Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet 1999;22:139-44.
26. Abecasis G, Noguchi E, Heinzmann A et al. Extent and distribution of linkage disequilibrium in three genomic regions. Am J Hum Genet 2001;68:191-7.
27. Baerwald CG, Panayi GS, Lanchbury JS. Corticotropin releasing hormone promoter region polymorphisms in rheumatoid arthritis. J Rheumatol 1997;24:215-6.
28. Baerwald CG, Mok CC, Tickly M et al. Corticotropin releasing hormone (CRH) promoter polymorphisms in various ethnic groups of patients with rheumatoid arthritis. Z Rheumatol 2000;59:29-34.
29. Pritchard JK, Rosenberg NA. Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet 1999;65:220-8.
30. Devlin B, Roeder K, Wasserman L. Genomic control, a new approach to genetic-based association studies. Theor Popul Biol 2001;60:155-66.