Edema in the Nephrotic Syndrome: New Aspect of an Old Enigma

Journal of the American Society of Nephrology

Volumn 14, Issue 12, 2003, Pages 3288-3289

  Hamm, L Lee ^a   Batuman, Vecihi ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 3;

ALBUMIN BLOOD LEVEL; DISEASE COURSE; EDITORIAL; ENDOCYTOSIS; ENZYME ACTIVITY; HUMAN; KIDNEY PROXIMAL TUBULE; MICROALBUMINURIA; NEPHROTIC SYNDROME; ONCOTIC PRESSURE; PRIORITY JOURNAL; SALT LOSING NEPHRITIS; SODIUM ABSORPTION; SODIUM RETENTION; SODIUM TRANSPORT;

EID: 0344667749     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000102671.77794.33     Document Type: Editorial

References (16)

1. + exchanger 3 in OKP cells. J Am Soc Nephrol 14: 3008-3016, 2003
2. Earley LE, Forland M. Nephrotic syndrome. In: Strauss and Welt's Diseases of the Kidney. edited by Earley LE, Gottschalk CW, Boston, Little, Brown and Company, 1979, pp 765-813.
3. Palmer BF, Alpern RJ. Pathogenesis of edema formation in the nephrotic syndrome. Kidney Int Suppl 59: S21-S27, 1997
4. Deschenes G, Feraille E, Doucet A. Mechanisms of oedema in nephrotic syndrome: Old theories and new ideas. Nephrol Dial Transplant 183: 454-456, 2003
5. Chandra M, Hoyer JR, Lewy JE. Renal function in rats with unilateral proteinuria produced by renal perfusion with amino-nucleoside. Pediatr Res 15: 340-344, 1981
6. Ichikawa I, Rennke HG, Hoyer JR, Badr KF, Schor N, Troy JL et al. Role for intrarenal mechanisms in the impaired salt excretion of experimental nephrotic syndrome. J Clin Invest 71: 91-103, 1983
7. Deschenes G, Wittner M, Stefano A, Jounier S, Doucet A. Collecting duct is a site of sodium retention in PAN nephrosis: a rationale for amiloride therapy. J Am Soc Nephrol 12: 598-601, 2001
8. Feraille E, Vogt B, Rousselot M, Barlet-Bas C, Cheval L, Doucet A, et al. Mechanism of enhanced Na-K-ATPase activity in cortical collecting duct from rats with nephrotic syndrome. J Clin Invest 91: 1295-1300, 1993
9. Valentin JP, Qiu C, Muldowney WP, Ying WZ, Gardner DG, Humphreys MH. Cellular basis for blunted volume expansion natriuresis in experimental nephrotic syndrome. J Clin Invest 90: 1302-1312, 1992
10. Valentin JP, Ying WZ, Sechi LA, Ling KT, Qiu C, Couser WG et al. Phosphodiesterase inhibitors correct resistance to natriuretic peptides in rats with Heymann Nephritis. J Am Soc Nephrol 7: 582-593, 1996
11. Allon M, Pasque CB, Rodriguez M. Sodium and water excretion in nephrotic patients: Effects of changes in renal haemodynamics. Clin Sci (Lond) 792: 123-129, 1990
12. Besse-Eschmann V, Klisic J, Nief V, Le Hir M, Kaissling B, Ambuhl PM. Regulation of the proximal tubular sodium/proton exchanger NHE3 in rats with puromycin aminonucleoside (PAN)-induced nephrotic syndrome. J Am Soc Nephrol 13: 2199-2206, 2002
13. Gekle M, Drumm K, Mildenberger S, Freudinger R, Gassner B, Silbernagl S. Inhibition of Na+-H+ exchange impairs receptor-mediated albumin endocytosis in renal proximal tubule-derived epithelial cells from opossum. J Physiol 520: 709-721, 1999
14. + exchange decreases albumin-induced NF-kappaB activation in renal proximal tubular cell lines (OK and LLC-PK1 cells). Eur J Med Res 6: 422-432, 2001
15. Remuzzi G, Bertani T. Pathophysiology of progressive nephropathies. N Engl J Med 339: 1448-1456, 1998
16. Rodriguez-Iturbe B, Herrera-Acosta J, Johnson RJ. Interstitial inflammation, sodium retention, and the pathogenesis of nephrotic edema: a unifying hypothesis. Kidney Int 62: 1379-1384, 2002