Expression change of Flk-2/Flt-3 on murine hematopoietic stem cells in an activating state

Experimental Hematology

Volumn 31, Issue 12, 2003, Pages 1331-1337

  Hasumura, Mai ^a   Imada, Chiharu ^a   Nawa, Katsuhiko ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FLT 3 RECEPTOR TYROSINE KINASE; FLT3 LIGAND; INTERLEUKIN 11; PROTEIN TYROSINE KINASE; STEM CELL FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD ANALYSIS; BONE MARROW CELL; CELL ACTIVATION; CELL ISOLATION; CELL SELECTION; CELL TRANSPLANTATION; CONTROLLED STUDY; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL; IRRADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

MURINAE;

EID: 0344666419     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2003.09.004     Document Type: Article

References (29)

1. Broudy V.C. Stem cell factor and hematopoiesis. Blood. 90:1997;1345-1364.
2. Matthews W., Jordan C.T., Wiegand G.W., Pardoll D., Lemishka I.R. A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell. 65:1991;1143-1152.
3. Rosnet O., Marchetto S., deLapeyriere O., Birnbaum D. Murine flt-3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family. Oncogene. 6:1991;1641-1650.
4. Lyman S.D., Jacobsen S.E.W. c-kit ligand and Flt3 ligand: Stem/ progenitor cell factors with overlapping yet distinct activities. Blood. 91:1998;1101-1134.
5. Okada S., Nakauchi H., Nagayoshi K., et al. Enrichment of murine hematopoietic stem cells that express c-kit molecule. Blood. 78:1991;1706-1712.
6. + stem cell compartment is accompanied by loss of self-renewal capacity. Immunity. 15:2001;659-669.
7. Orlic D., Fisher R., Nishikawa S., Nienhuis A.W., Bodine D.M. Purification and characterization of heterogeneous pluripotent hematopoietic stem cell populations expressing high levels of c-kit receptor. Blood. 82:1993;762-770.
8. Zeigler F.C., Bennett B.D., Jordan C.T., et al. Cellular and molecular characterization of the role of the FLK-2/FLT-3 receptor tyrosine kinase in hematopoietic stem cells. Blood. 84:1994;2422-2430.
9. Christensen J.L., Weissman I.L. Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells. Proc Natl Acad Sci U S A. 98:2001;14541-14546.
10. Miller C.L., Eaves C.J. Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstitution. Proc Natl Acad Sci U S A. 94:1997;13648-13653.
11. Oostendorp R.A.J., Audet J., Eaves C.J. High-resolution tracking of cell division suggests similar cell cycle kinetics of hematopoietic stem cells stimulated in vitro and in vivo. Blood. 95:2000;855-862.
12. Yonemura Y., Ku H., Lyman S.D., Ogawa M. In vitro expansion of hematopoietic progenitors and maintenance of stem cells: Comparison between FLT3/FLK-2 ligand and KIT ligand. Blood. 89:1997;1915-1921.
13. Bryder D., Jacobsen S.E.W. Interleukin-3 supports expansion of long-term multilineage repopulating activity after multiple stem cell divisions in vitro. Blood. 96:2000;1748-1755.
14. Jacobsen S.E.W., Okkenhaug C., Mykleburst J., Veiby O.P., Lyman S.D. The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: Synergistic interactions with interleukin (IL)-11, IL-12, and other hematopoietic growth factors. J Exp Med. 181:1995;1357-1363.
15. Li C.L., Jhonson G.R. Murine hematopoietic stem and progenitor cells: I. Enrichment and biologic characterization . Blood. 85:1995;1472-1479.
16. Harrison D.E., Jordan C.T., Zhong R.K., Astle C.M. Primitive hematopoietic stem cells: Direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations. Exp Hematol. 21:1993;206-219.
17. Iscove N.N., Nawa K. Hematopoietic stem cells expand during serial transplantation in vivo without exhaustion. Curr Biol. 7:1977;805-808.
18. 41 and W. EMBO J. 9:1990;1805-1813.
19. Miller C., Rebel V.I., Lemieux M.E., Helgason C.D., Lansdorp P.M., Eaves C.J. Studies of W mutant mice provide evidence for alternate mechanism capable of activating hematopoietic stem cells. Exp Hematol. 24:1996;185-194.
20. Trevisan M., Yan X.-Q., Iscove N.N. Cycle initiation and colony formation in culture by murine marrow cells with long-term reconstituting potential in vitro. Blood. 88:1996;4149-4158.
21. + murine hematopoietic cells. Blood. 80:1992;3044-3050.
22. Ikuta K., Weissman I.L. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor their generation. Proc Natl Acad Sci U S A. 89:1992;1502-1506.
23. low/negative hematopoietic stem cell. Science. 273:1996;242-245.
24. Matsuoka S., Ebihara Y., Xu M.-J., et al. CD34 expression on long-term repopulating hematopoietic stem cells changes during developmental stages. Blood. 97:2001;419-425.
25. Ito T., Tajima F., Ogawa M. Developmental changes of CD34 expression by murine hematopoietic stem cells. Exp Hematol. 28:2000;1269-1273.
26. Sato T., Laver J.H., Ogawa M. Reversible expression of CD34 by murine hematopoietic stem cells. Blood. 94:1999;2548-2554.
27. Mackarenhtschian K., Hardin J.D., Moore K.A., Boast S., Goff S.P., Lemischka I.R. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity. 3:1995;147-161.
28. McKenna H.J., Stocking K.L., Miller R.E., et al. Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood. 95:2000;3489-3497.
29. Sitnicka E., Bryder D., Theilgaard-Mönch K., Buza-Vidas N., Adolfsson J., Jacobsen E.W. Key role of flt3 ligand in regulation of the common lymphoid progenitor but not maintenance of the hematopoietic stem cell pool. Immunity. 17:2002;463-472.