Insulin sensitivity and endothelial function: A physiological relationship with pathophysiological significance?

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 7, Issue 2, 1997, Pages 113-116

  Petrie, John R ^a   Cleland, Stephen J ^a  

^a WESTERN INFIRMARY   (United Kingdom)

Author keywords

Blood pressure; Endothelium; Insulin; Nitric oxide; Skeletal muscle

Indexed keywords

EID: 0344615417     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

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2. Baron AD (1993) Cardiovascular actions of insulin in humans: implications for insulin sensitivity and vascular tone. Baillière's Clinical Endocrinology and Metabolism 7: 961-987
3. Ueda S, Petrie JR, Elliott HL, Connell JMC (1995) Insulin-mediated vasodilatation is dependent on local glucose concentrations (abstract). Hypertension 26: 561
4. Vallance P, Collier J, Moncada S (1989) Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet ii: 997-1000
5. Scherrer U, Randin D, Vollenweider P, Vollenweider L, Nicod P (1994) Nitric oxide accounts for insulin's vascular effects in humans. J Clin Invest 94: 2511-2515
6. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD (1994) Insulin-mediated skeletal muscle vasodilatation is nitric oxide dependent. J Clin Invest 94: 1172-1174
7. Hollenbeck G, Reaven GM (1987) Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance. J Clin Endocrinol. Metab 64: 1169-1173
8. Petrie JR, Ueda S, Webb DJ, Elliott HL, Connell JMC (1996) Insulin sensitivity and endothelial function: a physiological relationship with implications for pathophysiology of cardiovascular disease. Circulation 93: 1331-1333
9. Barker DJP, Hales CN, Fall CHD, Osmond C, Phipps K, Clark PMS (1993) Type 2 (non-insulin-dependent) diabetes mellitus, hypertension, and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 36: 62-67
10. Cleland SJ, Petrie JR, Ueda S, Elliott HL, Connell JMC (1996) Systemic inhibition of endothelial nitric oxide synthesis enhances insulin sensitivity in man (abstract). Diabetic Medicine 13 (Suppl 7): S18 (A6)
11. Haynes WG, Noon JP, Walker B, Webb DJ (1993) Inhibition of nitric oxide synthesis increases blood pressure in healthy humans. J Hypertension; 11: 1375-1380
12. Gardiner SM, Kemp PA, Bennett T (1991) Effects of N(G)-nitro-L-arginine methyl ester on vasodilator responses to acetylcholine, 5′-N-ethylcarboxamidoadenosine or salbutamol in conscious rats. Br J Pharmacol 103: 1725-1732