Developmental regulation of the serotonergic transmitter phenotype in rostral and caudal raphe neurons by transforming growth factor-βs

Journal of Neuroscience Research

Volumn 56, Issue 5, 1999, Pages 531-538

  Galter, Dagmar ^a   Böttner, Martina ^a   Unsicker, Klaus ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

5,7 dihydroxytryptamine uptake; Embryonic rat raphe; TGF type II receptor; Tryptophan hydroxylase

Indexed keywords

SEROTONIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; TRYPTOPHAN HYDROXYLASE;

ANIMAL CELL; ARTICLE; BRAIN STEM; CELL DIFFERENTIATION; CELL MATURATION; EMBRYO; IMMUNOCYTOCHEMISTRY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAPHE NUCLEUS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEROTONINERGIC SYSTEM; SUPERIOR COLLICULUS;

5,7-DIHYDROXYTRYPTAMINE; ACTIVIN RECEPTORS; ANIMALS; BIOLOGICAL TRANSPORT; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GESTATIONAL AGE; NEURONS; PREGNANCY; PROTEIN-SERINE-THREONINE KINASES; RAPHE NUCLEI; RATS; RATS, WISTAR; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEROTONIN; TRANSFORMING GROWTH FACTOR BETA; TRYPTOPHAN HYDROXYLASE;

EID: 0344603565     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19990601)56:5<531::AID-JNR8>3.0.CO;2-O     Document Type: Article

References (37)

1. Aitken AR, Törk I. 1988. Early development of serotonin-containing neurons and pathways as seen in wholemount preparation of the fetal rat brain. J Comp Neurol 274:32-47.
2. Altar CA, Boylan CB, Fritsche M, Jones BE, Jackson C, Wiegand SJ, Linsay RM, Hyman C. 1994. Efficacy of brain-derived neurotrophic factor and neurotrophin-3 on neuro-chemical and behavioral deficits associated with partial nigrostriatal dopamine lesions. J Neurochem 63:1021-1032.
3. Attisano L, Wrana JL. 1998. Mads and Smads in TGF beta signalling. Curr Opin Cell Biol 10:188-194.
4. Azmitia EC, Dolan K, Whitaker-Azmitia PM. 1990. S-100b but not NGF, EGF, insulin or calmodulin is a CNS serotonergic growthfactor. Brain Res 516:354-356.
5. Baumgarten HG, Grozdanovic Z. 1997. Serotonergic neurons and 5-HT receptors in the CNS. In: Baumgarten HG, Göthert M, editors. Handbook of experimental pharmacology. Berlin-Heidelberg: Springer-Verlag, p 41-88.
6. Böttner M, Unsicker K, Suter-Crazzolara C. 1996. Expression of TGF-beta type II receptor mRNA in the CNS. Neuroreport 7:2903-2907.
7. Chan YL, Wool IG. 1991. The primary structure of rat ribosomal protein S6. J Biol Chem 263:2891-2899.
8. Daval G, Verge D, Basbaum AI, Bourgoin S, Harmon M. 1987. Autoradiographic evidence of serotonin binding sites on primary afferent fibers in the dorsal horn of the rat spinal cord. Neurosci Lett 83:71-76.
9. Engele J, Bohn MC. 1991. The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia. J Neurosci 11:3070-3078.
10. Feldman RS. 1997. Serotonin. In: Feldman RS, Meyer JS, Quenzer LF, editors. Principles of neuropsychopharmacology. Sunderland, MA: Sinauer Assoc. Publ. p 349-390.
11. Flanders KC, Ludecke G, Engels S, Hamm C, Cissel DS, Roberts AB, Kondaiah P, Lafyatis R, Sporn MB, Unsicker K. 1991. Localization and actions of transforming growth factor-beta-s in the embryonic nervous system. Development 113:183-191.
12. Galter D, Unsicker K. 1999. Regulation of the transmitter phenotype of rostral and caudal groups of cultured serotonergic raphe neurons. Neuroscience 87:549-560.
13. Galter D, Böttner M, Krieglstein K, Schömig E, Unsicker K. In press. Differential regulation of distinct phenotypic features of serotonergic neurons by bone morphogenetic proteins. Eur J Neurosci.
14. Jacobs BL, Azmitia EC. 1992. Structure and function of the brain serotonin system. Physiol Rev 72(1):165-229.
15. Kingsley DM. 1994. The TGF-β superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev 8:133-146.
16. Krieglstein K, Unsicker K. 1994. Transforming growth factor-β promotes survival of midbrain dopaminergic neurons and protects them against N-methyl-4-phenyl-pyridinium ion toxicity. Neuroscience 4:1189-1196.
17. Krieglstein K, Sutter-Crazzolara C, Fischer WH, Unsicker K. 1995. TGF-β superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity. EMBO J 14:736-742.
18. Krieglstein K, Sutter-Crazzolara C, Unsicker K. 1995. Development of mesencephalic dopaminergic neurons and the transforming growth factor-beta superfamily. J Neural Transm Suppl 46:209-216.
19. Lauder JM, Wallace JA, Krebs H, Petrusz P, McCarthy K. 1982. In vivo and in vitro development of serotonergic neurons. Brain Res Bull 9:605-625.
20. Lindholm D, Castren E, Kiefer R, Zafra F, Thoenen H. 1992. Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation. J Cell Biol 117:395-400.
21. Logan A, Berry M, Gonzalez AM, Frautschy SA, Sporn MB, Baird A. 1994. Effects of transforming growth factor beta 1 on scar production in the injured central nervous system of the rat. Eur J Neurosci 6:355-363.
22. Liu J, Lauder JM. 1992. S-100 beta and insulin-like growth factor-II differentially regulate growth of developing serotonin and dopamine neurons in vitro. J Neurosci Res 33:248-256.
23. Mamounas LM, Blue ME, Siuciak JA, Altar A. 1995. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in the rat brain. J Neurosci 15:7929-7939.
24. Martin-Iverson M, Todd KG, Altar CA. 1994. Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamin and serotonin metabolism and related behaviors: interactions with amphetamine. J Neurosci 14:1262-1270.
25. McKinnon RD, Piras G, Ida J, Dubois-Dalq M. 1993. A role of GF-beta in oligodendrocyte differentiation. J Biol Chem 121:1397-1401.
26. Moiseiwitsch JR, Lauder JM. 1995. Serotonin regulates mouse cranial neural crest migration. Proc Natl Acad Sci USA 92:7182-7186.
27. Morgan TE, Nichols NR, Pasinetti GM, Finch CE. 1993. TGF-beta 1 mRNA increases in macrophage/microglial cells of the hippocampus in response to deafferentation and kainic acid-induced neurodegeneration. Exp Neurol 120:291-301.
28. Pasinetti GM, Nichols NR, Tocco G, Morgan T, Laping N, Finch CE. 1993. Transforming growth factor beta 1 and fibronectin messenger RNA in rat brain: responses to injury and cell-type localization. Neuroscience 54:893-907.
29. Poulsen KT, Armanini MP, Klein RD, Hynes MA, Phillips HS, Rosenthal A. 1994. TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons. Neuron 13:1245-1252.
30. Roberts AS, Sporn MB. 1990. The transforming growth factor-βs. In: Sporn MB, Roberts AS, editors. Handbook of experimental pharmacology 95. Heidelberg: Springer-Verlag, p 419-472.
31. Sambrook J, Fritsch EF, Maniatis T. 1989. Molecular cloning: a laboratory manual. New York: Cold Spring Harbor Lab. Press, p 270-281.
32. Siuciak JA, Boylan C, Fritsche M, Altar CA, Lindsay RM. 1996. BDNF increases monoaminergic activity in rat brain following intracerebroventricular or intraparenchymal administration. Brain Res 710:11-20.
33. Tsuchida K, Lewis KA, Mathews LS, Vale WW. 1993. Molecular characterization of rat transforming growth factor-beta type II receptor. Biochem Biophys Res Commun 191:790-795.
34. Unsicker K, Meier C, Krieglstein K, Sartor BM, Flanders KC. 1996. Expression, localization, and function of transforming growth factor-beta s in embryonic chick spinal cord, hindbrain and dorsal root ganglia. J Neurobiol 29: 262-276.
35. Vivien D, Bernaudin M; Buisson A, Divoux D, MacKenzie ET, Nouvelot A. 1998. Evidence of type I and II transforminc growth factor-beta receptors in central nervous system: changes induced by focal cerebral ischemia. J Neurochem 70:2296-2304.
36. Wallace JA, Lauder JM. 1983. Development of the serotonergic system in the rat embryo: an immuncytochemical study. Brain Res Bull 10:459-479.
37. Wang J, Kuliszewski M, Yee W, Sedlackova L, Xu J, Tseu I, Post M. 1995. Cloning and expression of glucocorticoid-induced genes in fetal rat lung fibroblasts. Transforming growth factor-beta 3. J Biol Chem 270:2722-2728.