Keratinocyte growth factor enhances glutathione redox state in rat intestinal mucosa during nutritional repletion

Journal of Nutrition

Volumn 129, Issue 7, 1999, Pages 1278-1284

  Jonas, Carolyn R ^a,c   Estívariz, Concepción F ^a   Jones, Dean P ^a,c   Gu, Li H ^a   Wallace, Timothy M ^a   Diaz, Emma E ^a   Pascal, Robert R ^a   Cotsonis, George A ^b   Ziegler, Thomas R ^a,c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c EMORY UNIVERSITY   (United States)

Author keywords

Glutathione; Intestine; Keratinocyte growth factor; Protein energy malnutrition; Rats

Indexed keywords

GLUTATHIONE; GLUTATHIONE DISULFIDE; KERATINOCYTE GROWTH FACTOR; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; COLON; FOOD DEPRIVATION; FOOD INTAKE; ILEUM; INTESTINE CRYPT; INTESTINE FUNCTION; INTESTINE MUCOSA; INTESTINE VILLUS; JEJUNUM; MALE; MALNUTRITION; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; RAT; REFEEDING;

EID: 0344517354     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/129.7.1278     Document Type: Article

References (42)

1. Aw, T. Y., Williams, M. W. & Gray, L. (1992) Absorption and lymphatic transport of peroxidized lipids by rat small intestine in vivo: Role of mucosal GSH. Am. J. Physiol. 262: G99-G106.
2. Bai, C. & Jones, D. P. (1996) GSH transport and GSH-dependent detoxication in small intestine of rats exposed in vivo to hypoxia. Am. J. Physiol. 271: G701-706.
3. Bauman, P. F., Smith, T. K. & Bray, T. M. (1988) The effect of dietary protein and sulfur amino acids on hepatic glutathione concentration and glutathione-dependent enzyme activities in the rat. Can. J. Physiol. Pharmacol. 66: 1048-1052.
4. Bray, T. M. & Taylor C. G. (1994) Enhancement of tissue glutathione for antioxidant and immune functions in malnutrition. Biochem. Pharmacol. 7: 2113-2123.
5. Burdon, R. H., Alliangana, D. & Gill, V. (1994) Endogenously generated active oxygen species and cellular glutathione levels in relation to BHK-21 cell proliferation. Free Radical Res. 21: 121-123.
6. Cai, J., Sun, W. M. S. Lu, S. C. (1995) Hormonal and cell density regulation of hepatic γ-glutamylcysteine synthetase gene expression. Mol. Pharmacol. 48: 212-218.
7. Chen, M. F., Chen, L. T. & Boyce, H. W. (1988) Effect of endotoxin on the rat colon glutathione level. Biochem. Biophys. Res. Com. 151: 844-850.
8. Cho, E. S., Sahyoun, N. & Stegnick, L. D. (1981) Tissue glutathione as a cyst(e)ine reservoir during fasting and refeeding of rats. J. Nutr. 111: 914-922.
9. Clarke, W. M. (1960) The standard hydrogen half-cell and the standardization of oxidation-reduction potentials and pH numbers. In: Oxidation-Reduction Potentials of Organic Systems (, ed.), pp. 248-272. Waverly Press, Baltimore, MD.
10. Cornell, J. S. & Meister, A. (1976) Glutathione and-glutamyl cycle enzymes in crypt and villus tip cells of rat jejunal mucosa. Proc. Natl. Acad. Sci. 78: 420-422.
11. Dahm, L. J. & Jones, D. P. (1994) Secretion of cysteine and glutathione from mucosa to lumen in rat small intestine. Am. J. Physiol. 267: G292-G300.
12. Darmon, N., Pelissier, M. A., Heyman, M., Albrecht, R. & Desjeux, J. F. (1993) Oxidative stress may contribute to the intestinal dysfunction of weanling rats fed a low protein diet. J. Nutr. 123: 1068-1075.
13. Drucker, D. J. (1997) Epithelial cell growth and differentiation. I. Intestinal growth factors. Am. J. Physiol. 273: G3-6.
14. Estívariz, C. F., Jonas, C. R., Gu, L. H., Diaz, E. E., Wallace, T. M., Pascal, R. R., Farrell, C. L. & Ziegler, T. R. (1998) Gut-trophic effects of keratinocyte growth factor in rat small intestine and colon during enteral refeeding. J. Parent. Enteral. Nutr. 22: 1-9.
15. Farrell, C. L., Bready, J. V., Rex, K. L., Chen, J. N., DiPalma, C. R., Whticomb, K. L., Yin, S., Hill, D. C., Wiernann, B., Starnes, C. O., Havill, A. M., Lu, Z. N., Aukerman, S. L., Pierce, G. F., Thomason, A., Potten, C. S., Ulich, T. R. & Lacey, D. L. (1998) KGF protects from chemotherapy and radiation-induced gastrointestinal injury and mortality. Cancer Res 58: 933-939.
16. Finch, P. W., Rubin, J. S., Miki, T., Ron, D. & Aaronson, S. A. (1989) Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science 245: 752-755.
17. Gilbert, H. F. (1989) Thermodynamic and kinetic constraints on thiol/disulfide exchange involving glutathione redox buffers. In: Glutathione Cennetennial. Molecular Perspectives and Clinical Implications (Taniguchi, N., Higashi, T., Sakamoto, Y. & Meister, A., eds.), pp. 73-87. Academic Press: San Diego, CA.
18. Hagemann, R. F. & Stragand, J. J. (1977) Fasting and refeeding: cell kinetic response of jejunum, ileum and colon. Cell Tissue Kinet. 10: 3-14.
19. Hagen, T. M., Wierzbicka, G. T., Bowman, B. B., Yee, T. Y. & Jones, D. P. (1990) Fate of dietary glutathione: Disposition in the gastrointestinal tract. Am. J. Physiol. 259: G530-G535.
20. Housley, R. M., Morris, C. F., Boyle, W., Ring, B., Biltz, R., Tarpley, J. E., Aukerman, S. L., Devine, P. L., Whitehead, R. H. & Pierce, G. F. (1994) Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract. J. Clin. Invest. 94: 1764-1777.
21. Hutter, D. E., Till, B. G. & Greene, J. J. (1997) Redox state changes in density-dependent regulation of proliferation. Exp. Cell. Research 232: 435-438.
22. Hwang, C. & Sinskey, A. J. (1991) The role of oxidation-reduction potential in monitoring growth of cultured mammalian cells. In: Production of Biologicals from Animal Cells in Culture (Spier, R. E., Griffiths, J. B. & Meignier, B., eds.), pp. 548-569. Butterworth-Heinemann Ltd., Oxford, UK.
23. Jahoor, F., Wykes, L. J., Reeds, P. J., Henry, J. F., del Rosario, M. P. & Frazer, M. E. (1995) Protein-deficient pigs cannot maintain reduced glutathione homeostasis when subjected to the stress of inflammation. J. Nutr. 125: 1462-1472.
24. Jones, D. P., Kurtz, J. C., Samiec, P. S., Sternberg, P., Reed, R. L. & Brown, L. S. (1998) GSH measurement in human plasma. Evaluation of sample collection, storage and derivatization conditions for analysis of dansyl derivatives by HPLC. Clin. Chem. Acta 275: 175-184.
25. Kaplowitz, N., Eberle, D. E., Petrini, J., Touloukian, J., Corvase, M. C. & Kuhlenkamp, J. (1983) Factors influencing the efflux of hepatic glutathione into bile in rats. J. Pharmacol. Exp. Then 224: 141-147.
26. Kelly, F. J. (1993) Glutathione content of the small intestine: Regulation and function. Br. J. Nutr. 69: 589-596.
27. Lash, L. H., Hagen, T. M. & Jones, D. P. (1986) Exogenous glutathione protects intestinal epithelial cells from oxidative injury. Proc. Natl. Acad. Sci .83: 4641-4645.
28. Lu, S. C., Sun, W. M., Yi, J., Ookhtens, M., Sze, G. & Kaplowitz, N. (1996) Role of two recently cloned rat liver GSH transporters in the ubiquitous transport of GSH in mammalian cells. J. Clin. Invest. 97: 1488-1496.
29. Martensson, J., Jain, A. & Meister, A. (1989) Glutathione is required for intestinal function. Proc. Natl. Acad. Sci. 87: 1715-1719.
30. Meister, A. (1991) Glutathione deficiency produced by inhibition of its synthesis and its reversal: Applications in research and therapy. Pharmacol. Ther.51: 155-194.
31. Meynial-Denis, D., Mignon, M., Foucat, L., Beilicki, G., Ouali, A., Tassy, C., Renou, J., Grizard, J. & Arnal, M. (1998) pH is regulated differently by glucose in skeletal muscle from fed and starved rats: A study using 31P-NMR spectroscopy. J. Nutr. 128: 28-34.
32. Ogasawara, T., Ohnhaus, E. E. & Hoensch, H. P. (1989) Glutathione and its related enzymes in the small intestinal mucosa of rats: Effects of starvation and diet. Res. Exp. Med. 189: 195-204.
33. Rost, J. & Rapaport, S. (1964) Reduction potential of glutathione. Nature 201: 185-186.
34. Saigers, C. P., Reimann, D., Theis, E. & Younes, M. (1988) Glutathione and GSH-dependent enzymes in the gastrointestinal mucosa of the rat. Cancer Lett. 40: 71-76.
35. Smith, C. V., Jones, D. P., Guenthner, T. M., Lash, L. H. & Lauterburg, B. H. (1996) Compartmentation of glutathione: Implications for the study of toxicity and disease. Toxicol. Appl. Pharmacol. 140: 1-12.
36. Steiner, M., Bourges, H. R., Freedman, L. S. & Gray, S. J. (1968) Effect of starvation on the tissue composition of the small intestine in the rat. Am. J. Physiol. 215: 75-77.
37. Sundaresan, M., Yu, Z. X., Ferrans, V. J., Irani, K. & Finkel, T. (1995) Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270: 296-299.
38. Wang, X., Wang, Q., Andersson, R., Andersson, R. & Bergmark, S. (1993) Intramucosal pH and oxygen extraction in the gastrointestinal tract after major liver resection in rats. Eur. J. Surg. 159: 81-87.
39. Zeeh, J. M., Procaccino, F., Hoffman, P., Aukerman, S. L., McRoberts, J. A., Soltani, S., Pierce, G. F., Lakshmanan, J., Lacey, D. & Eysselein, V. E. (1996) Keratinocyte growth factor ameliorates mucosal injury in an experimental model of colitis in rats. Gastroenterology 110: 1077-1083.
40. Ziegler, D. M. (1985) Role of reversible oxidation-reduction of enzyme thioldisulfides in metabolic regulation. Annu. Rev. Biochem. 54: 305-329.
41. Ziegler, T. R., Almahfouz, A., Pedrini, M. T. & Smith, R. J. (1995) A comparison of rat small intestine insulin and IGF-I receptors during fasting and refeeding. Endocrinology 136: 5148-5154.
42. Ziegler, T. R., Puckett, A. B., Griffiths, D. P. & Galloway, J. R. (1997) Interactions between nutrients and growth factors in cellular growth and tissue repair. In: Growth Factors and Wound Healing: Basic Science and Potential Clinical Applications (Ziegler, T. R., Pierce, G. F. & Herndon, D. N., eds.), pp. 104-150. Springer-Verlag, New York, NY.