GSH transport and GSH-dependent detoxication in small intestine of rats exposed in vivo to hypoxia

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 271, Issue 4 34-4, 1996, Pages

  Bai, Changli ^a   Jones, Dean P ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

absorption; adrenergic agonists; glutathione peroxidase; glutathione S transferase; glutathione transport; peroxides

Indexed keywords

GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE;

ANIMAL EXPERIMENT; ARTICLE; CELL PROTECTION; DETOXIFICATION; ENZYME ACTIVITY; GLUTATHIONE METABOLISM; HYPOXIA; INTESTINE CELL; INTESTINE EPITHELIUM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMALL INTESTINE ABSORPTION;

EID: 0029958676     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1996.271.4.g701     Document Type: Article

References (32)

1. Ames, B. N. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science Wash. DC 221: 1256-1264, 1983.
2. Aw, T. Y., C. Bai, and D. P. Jones. Small intestinal enterocytes. Methods Toxicol. 1: 193-201, 1993.
3. Aw, T. Y., X. Shan, A. H. Sillau, and D. P. Jones. Effect of chronic hypoxia on acetaminophen metabolism in rat. Biochem. Pharmacol. 42: 1029-1038, 1991.
4. Aw, T. Y., and M. W. Williams. Intestinal absorption and lymphatic transport of peroxidized lipids in rats: effect of exogenous GSH. Am. J. Physiol. 263 (Gastrointest. Liver Physiol. 26): G665-G672, 1992.
5. Chinn, K. S., and J. P. Hannon. Efficiency of food utilization at high altitude. Federation Proc. 28: 944-947, 1969.
6. Deneke, S. M., and B. L. Fanburg. Regulation of cellular glutathione. Am. J. Physiol. 257 (Lung Cell. Mol. Physiol. 1): L163-L173, 1989.
7. Flagg, E. W., R. J. Coates, D. P. Jones, J. W. Eley, E. W. Gunter, B. Jackson, and R. S. Greenberg. Plasma total glutathione in humans and its association with demographic and health-related factors. Br. J. Nutr. 703: 797-808, 1993.
8. Ganong, W. F. Respiratory adjustments in health and disease. In: Review of Medical Physiology. Norwalk, CT: Appleton and Lange, 1989, p. 579-592.
9. Grafstrom, R., P. Moldeus, B. Andersson, and S. Orrenius. Xenobiotic metabolism by isolated rat small intestinal cells. Med. Biol. Helsinki 57: 287-293, 1979.
10. Hagen, T. M., C. Bai, and D. P. Jones. Stimulation of GSH absorption in small intestine by α-adrenergic agonists. FASEB J. 5: 2721-2727, 1991.
11. Hagen, T. M., and D. P. Jones. Transepithelial transport of glutathione in vascularly perfused small intestine of rat. Am. J. Physiol. 252 (Gastrointest. Liver Physiol. 15): G607-G613, 1987.
12. Hagen, T. M., G. T. Wierzbicka, B. B. Bowman, T. Y. Aw, and D. P. Jones. Fate of dietary glutathione. Disposition in the gastrointestinal tract. Am. J. Physiol. 259 (Gastrointest. Liver Physiol. 22): G530-G535, 1990.
13. Hagen, T. M., G. T. Wierzbicka, A. U. Sillau, B. B. Bowman, and D. P. Jones. Bioavailability of dietary glutathione. Effect on plasma concentration. Am. J. Physiol. 259 (Gastrointest. Liver Physiol. 22): G524-G529, 1990.
14. Hannon, J. P. Nutrition at high altitude. In: Environmental Physiology: Aging, Heat and Altitude. New York: Liss, 1980, p. 309-327.
15. Hart, B. B., G. G. Stanford, M. G. Ziegler, C. R. Lake, and B. Chernow. Catecholamines: study of interspecies variation. Crit. Care Med. 17: 1203-1222, 1989.
16. Hopkins, J., and G. R. Thudhope. Glutathione peroxidase in human red cells in health and disease. Br. J. Haematol. 25: 563-575, 1973.
17. 5 reductase and cytochrome P-450 as electron carriers in microsomal NADH-peroxidase activity. Arch. Biochem. Biophys. 160: 230-245, 1974.
18. Hunjan, M., and D. Evered. Absorption of glutathione from the gastrointestinal tract. Biochim. Biophys. Acta 815: 184-188, 1985.
19. Itzhaki, R. F., and D. M. Gill. A micro-biuret method for estimating proteins. Anal. Biochem. 9: 401-410, 1964.
20. Jones, D. P. The role of oxygen concentration in oxidative stress: hypoxic and hyperoxic models. In: Oxidative Stress, edited by H. Sies. New York: Academic, 1985, p. 151-195.
21. Jones, D. P., T. Y. Aw, D. L. Tribble and X. Shan. t-Butylhydroperoxide toxicity in hepatocytes during hypoxia and anoxia. Adv. Biosci. 76: 13-19, 1989.
22. Kacimi, R., J. P. Richalet, and B. Crozatier. Altitude and pregnancy. Apropos of an experimental study on the pregnant rat. J. Gynecol. Obstet. Biol. Reprod. 22: 605-610, 1993.
23. Kowalski, D. P., R. M. Feeley, and D. P. Jones. Use of exogenous glutathione for metabolism of peroxidized methyl linoleate in rat small intestine. J. Nutr. 120: 1115-1121, 1990.
24. Lash, L. H., T. M. Hagen, and D. P. Jones. Exogenous glutathione protects intestinal epithelial cells from oxidative injury. Proc. Natl. Acad. Sci. USA 83: 4641-4645, 1986.
25. Lash, L. H., and D. P. Jones. Distribution of oxidized and reduced forms of glutathione and cysteine in rat plasma. Arch. Biochem. Biophys. 240: 585-592, 1985.
26. Lauterburg, B. H., J. D. Adams, and J. R. Mitchell. Hepatic glutathione homeostasis in the rat: efflux accounts for glutathione turnover. Hepatology 4: 586-590, 1984.
27. Lawrence, R. A., and R. F. Burk. Species, tissue and subcellular distribution of non Se-dependent glutathione peroxidase activity. J. Nutr. 108: 211-215, 1978.
28. +)-ATPase in an experimental model of hypoxia in rats. Proc. Soc. Exp. Biol. Med. 181: 87-97, 1986.
29. Meister, A., S. S. Tate, and O. W. Griffith. γ-Glutamyl transpeptidase. Methods Enzymol. 113: 237-243, 1985.
30. Reed, D. J., J. R. Babson, P. W. Beatty, A. E. Brodie, W. W. Ellis, and D. W. Potter. HPLC analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides. Anal. Biochem. 106: 55-62, 1980.
31. Shan, X., T. Y. Aw, E. R. Smith, M. Ingelman-Sundberg, B. Mannervik, T. Iyanagi, and D. P. Jones. Effect of chronic hypoxia on detoxication enzyme activities in rat liver. Biochem. Pharmacol. 43: 2421-2426, 1992.
32. Siegers, C.-P., D. Reimann, E. Thies, and M. Younes. Glutathione and GSH-dependent enzymes in the gastrointestinal mucosa of the rat. Cancer Lett. 40: 71-76, 1988.