Parathyroid hormone responses of cyclic AMP-, serum- and phorbol ester-responsive reporter genes in osteoblast-like UMR-106 cells

Molecular and Cellular Endocrinology

Volumn 139, Issue 1-2, 1998, Pages 89-98

  Fluhmann B ^a   Zimmermann, U ^a   Muff, R ^a   Bilbe, G ^b   Fischer, J A ^a   Born, W ^a  

^a Research Laboratory for Calcium Metabolism   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Adenylyl cyclase; Bone; Parathyroid hormone; Receptor; Reporter gene

Indexed keywords

8 BROMO CYCLIC AMP; CYCLIC AMP; EPIDERMAL GROWTH FACTOR; FORSKOLIN; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; PARATHYROID HORMONE; PHORBOL 13 ACETATE 12 MYRISTATE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA TRANSFECTION; GENE EXPRESSION REGULATION; GENE INDUCTION; HORMONAL REGULATION; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; RAT; REPORTER GENE; SERUM;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; BASE SEQUENCE; BLOOD; CELL LINE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EPIDERMAL GROWTH FACTOR; FORSKOLIN; GENE EXPRESSION REGULATION; GENES, REPORTER; LUCIFERASES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MOLECULAR SEQUENCE DATA; OSTEOBLASTS; PARATHYROID HORMONE; RATS; REGULATORY SEQUENCES, NUCLEIC ACID; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; TRANSFECTION;

EID: 0344505743     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(98)00070-7     Document Type: Article

References (33)

1. Abou-Samra A.-B., Jüppner H., Force T., Freeman M.W., Kong X.-F., Schipani E., Urena P., Richards J., Bonventre J.V., Potts J.T. Jr, Kronenberg H.M., Segre G.V. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc. Natl. Acad. Sci. USA. 89:1992;2732-2736.
2. Arao M., Yamaguchi T., Sugimoto T., Fukase M., Chihara K. Involvement of protein kinase C in the stimulation of sodium-dependent phosphate transport by parathyroid hormone in osteoblast-like cells. Eur. J. Endocrinol. 131:1994;646-651.
3. + exchanger NHE-1 isoform in osteoblastic cells (UMR-106) via a cAMP-dependent pathway. J. Biol. Chem. 270:1995;23166-23172.
4. Burgering B.M., Pronk G.J., van Weeren P.C., Chardin P., Bos J.L. cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. EMBO J. 12:1993;4211-4220.
5. Civitelli R., Reid I.R., Westbrook S., Avioli L.V., Hruska K.A. PTH elevates inositol polyphosphates and diacylglycerol in a rat osteoblast-like cell line. Am. J. Physiol. 255:1988;660-667.
6. Eggenberger M., Flühmann B., Muff R., Lauber M., Lichtensteiger W., Hunziker W., Fischer J.A., Born W. Structure of a parathyroid hormone/parathyroid hormone-related peptide receptor of the human cerebellum and functional expression in human neuroblastoma SK-N-MC cells. Mol. Brain Res. 36:1996;127-136.
7. 2 osteoblast-like cells. J. Bone Miner. Res. 11:1996;1066-1074.
8. Fang M.A., Kujubu D.A., Hahn T.J. The effects of prostaglandin E2, parathyroid hormone, and epidermal growth factor on mitogenesis, signaling, and primary response genes in UMR 106-01 osteoblast-like cells. Endocrinology. 131:1992;2113-2119.
9. Faure M., Voyno-Yasenetskaya T.A., Bourne H.R. cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J. Biol. Chem. 269:1994;7851-7854.
10. Fujimori A., Cheng S.L., Avioli L.V., Civitelli R. Structure-function relationship of parathyroid hormone: activation of phospholipase-C, protein kinase-A and -C in osteosarcoma cells. Endocrinology. 130:1992;29-36.
11. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:1985;3440-3450.
12. Himmler A., Stratowa C., Czernilofsky A.P. Functional testing of human dopamine D1 and D5 receptors expressed in stable cAMP-responsive luciferase reporter cell lines. J. Recept. Res. 13:1993;79-94.
13. Hunter W.M., Greenwood F.C. Preparation of iodine-131 labeled human growth hormone of high specific activity. Nature. 194:1962;495-498.
14. Iida-Klein A., Varlotta V., Hahn T.J. Protein kinase C activity in UMR-106-01 cells: effects of parathyroid hormone and insulin. J. Bone Miner. Res. 4:1989;767-774.
15. Juppner H., Abou-Samra A.B., Freeman M., Kong X.F., Schipani E., Richards J., Kolakowski L.F. Jr, Hock J., Potts J.T. Jr, Kronenberg H.M., Segre G.V. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science. 254:1991;1024-1026.
16. Kano J., Sugimoto T., Fukase M., Fujita T. The activation of cAMP-dependent protein kinase is directly linked to the inhibition of osteoblast proliferation (UMR-106) by parathyroid hormone-related protein. Biochem. Biophys. Res. Commun. 177:1991;365-369.
17. Kaufmann M., Muff R., Born W., Fischer J.A. Functional expression of a stably transfected parathyroid hormone/parathyroid hormone related protein receptor complementary DNA in CHO cells. Mol. Cell. Endocrinol. 104:1994;21-27.
18. Kitten A.M., Hymer T.K., Katz M.S. Bidirectional modulation of parathyroid hormone-responsive adenylyl cyclase by protein kinase C. Am. J. Physiol. 266:1994;897-904.
19. Moran J., Hunziker W., Fischer J.A. Calcitonin and calcium ionophores: cyclic AMP responses in cells of a human lymphoid line. Proc. Natl. Acad. Sci. USA. 75:1978;3984-3988.
20. Ng K.W., Partridge N.C., Niall M., Martin T.J. Epidermal growth factor receptors in clonal lines of a rat osteogenic sarcoma and in osteoblast-rich rat bone cells. Calcif. Tissue Int. 35:1983;298-303.
21. Pausova Z., Bourdon J., Clayton D., Mattei M.G., Seldin M.F.X., Janicic N., Riviere M., Szpirer J., Levan G., Szpirer C., Goltzmann D., Hendy G.N. Cloning of a parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell line: chromosomal assignment of the gene in the human, mouse, and rat genomes. Genomics. 20:1994;20-26.
22. Pearman A.T., Chou W.Y., Bergman K.D., Pulumati M.R., Partridge N.C. Parathyroid hormone induces c-fos promoter activity in osteoblastic cells through phosphorylated cAMP response element (CRE)-binding protein binding to the major CRE. J. Biol. Chem. 271:1996;25715-25721.
23. Philbrick W.M., Wysolmerski J.J., Galbraith S., Holt E.X., Orloff J.J., Yang K.H., Vasavada R.C., Weir E.C., Broadus A.E., Stewart A.F. Defining the roles of parathyroid hormone-related protein in normal physiology. [Review] [293 refs]. Physiol. Rev. 76:1996;127-173.
24. Reid I.R., Civitelli R., Avioli L.V., Hruska K.A. Parathyroid hormone depresses cytosolic pH and DNA synthesis in osteoblast-like cells. Am. J. Physiol. 255:1988;9-15.
25. Rouleau M.F., Warshawsky H., Goltzman D. Parathyroid hormone binding in vivo to renal, hepatic, and skeletal tissues of the rat using a radioautographic approach. Endocrinology. 118:1986;919-931.
26. Sanders J.L., Stern P.H. Expression and phorbol ester-induced down-regulation of protein kinase c isozymes in osteoblasts. J. Bone Miner. Res. 11:1996;1862-1872.
27. Schägger H., von Jagow G. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166:1987;368-379.
28. Sugimoto T., Ikeda K., Kano J., Yamaguchi T., Fukase M., Chihara K. Cross-talk of parathyroid hormone- responsive dual signal transduction systems in osteoblastic osteosarcoma cells: its role in PTH-induced homologous desensitization of intracellular calcium response. J. Cell. Physiol. 158:1994;374-380.
29. Tatrai A., Lee S.K., Stern P.H. U-73122, a phospholipase C antagonist, inhibits effects of endothelin-1 and parathyroid hormone on signal transduction in UMR-106 osteoblastic cells. Biochim. Biophys. Acta. 1224:1994;575-582.
30. Verheijen M.H., Defize L.H. Parathyroid hormone inhibits mitogen-activated protein kinase activation in osteosarcoma cells via a protein kinase A-dependent pathway. Endocrinology. 136:1995;3331-3337.
31. Verheijen M.H.G., Defize L.H.K. Parathyroid hormone activates mitogen-activated protein kinase via a cAMP-mediated pathway independent of ras. J. Biol. Chem. 272:1997;3423-3429.
32. Vossler M.R., Yao H., York R.D., Pan M.G., Rim C.S., Stork P.J.S. cAMP activates MAP kinase and elk-1 through a b-raf- and rap1-dependent pathway. Cell. 89:1997;73-82.
33. Zajac J.D., Kearns A.K., Skurat R.M., Kronenberg H.M.X., Bringhurst F.R. Regulation of gene transcription and proliferation by parathyroid hormone is blocked in mutant osteoblastic cells resistant to cyclic AMP. Mol. Cell. Endocrinol. 1987:1992;69-77.