The Changes of Hepatic Metallothionein Synthesis and the Hepatic Damage Induced by Starvation in Mice

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 25, Issue 8, 2003, Pages 601-606

  Sogawa, N ^a   Sogawa, C A ^a   Fukuoka, H ^a   Mukubo, Y ^a   Yoneyama, T ^b   Okano, Y ^b   Furuta, H ^a   Onodera, Kenji ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

Hepatic damage; Metallothionein; Starvation

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CADMIUM CHLORIDE; METAL; METALLOTHIONEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EXPERIMENTAL MODEL; FEEDING; GENE EXPRESSION; LIVER INJURY; LIVER LEVEL; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN DETERMINATION; PROTEIN INDUCTION; PROTEIN SYNTHESIS; STARVATION; STRESS;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CADMIUM CHLORIDE; FOOD; GENE EXPRESSION REGULATION; INJECTIONS, SUBCUTANEOUS; LIVER; LIVER DISEASES; MALE; METALLOTHIONEIN; MICE; MICE, INBRED STRAINS; RNA, MESSENGER; SPAIN; STARVATION; TIME FACTORS;

EID: 0344496708     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2003.25.8.778079     Document Type: Article

References (25)

1. Kotsonis, F.N., Klaassen, C.D. Increase in hepatic metallothionein in rats treated with alkylating agents. Toxicol Appl Pharmacol 1979, 51: 19-27.
2. De, S.K., McMaster, M.T., Andrews, G.K. Endotoxin induction of murine metallothionein gene expression. J Biol Chem 1990, 265: 15267-74.
3. Oh, S.H., Deagen, J.T., Whanger, P.D., Weswig, P.H. Biological function of metallothionein. V. Its induction in rats by various stress. Am J Physiol 1978, 234: E282-5.
4. Hidalgo, J., Borras, M., Garvey, J.S., Armario, A. Liver, brain, and heart metallothionein induction by stress. J Neurochem 1990, 55: 651-4.
5. Onosaka. S., Min, K.S., Oo-ishi, K., Fujita, Y., Tanaka, K. Roles of metallothionein in the liver on acute cadmium toxicity in mice. IV. No preventive effect of starvation. Eisei Kagaku 1986, 32: 455-9.
6. Giralt, M., Gasull, T., Hernandez, J., Garcia, A., Hidalgo, J. Effect of stress, adrenalecmmy and changes in glutathione metabolism on rat kidney metallothionein content: Comparison with liver metallothionein. Bio Metals 1993, 6: 171-8.
7. Hamer, D.H. Metallothionein 1,2. Ann Rev Biochem 1986, 55: 913-51.
8. Klaassen, C.D., Liu, J., Choudhuri, S. Metallothionein: An intracellular protein to protect against cadmium toxicity. Annu Rev Pharmacol Toxicol 1999, 39: 267-94.
9. Shinogi, M., Nakazawa, M., Mori, I. The amount of metals sufficient to induce the production of metallothionein in rat liver. Eisei kagaku 1982, 28: 119-25.
10. Onosaka, H., Yoshiya, S., Min, K.S., Fukuhara, T., Tanaka, K. The induced synthesis of metallothionein in various tissues of rat after injection of various metals, Eisei Kagaku 1983, 29: 221-5.
11. Probst, G.S., Bousquet, W.F., Miya, T.S. Correlation of hepatic metallothionein concentrations with acute cadmium toxicity in the mouse. Toxicol Appl Pharmacol 1977, 39: 61-9.
12. Liu, Y.P., Liu, J., Iszard, M.B., Andrews, G.K., Palmiter, R.D., Klaassen, C.D. Transgenic mice that overexpress metallothionein-I are protected from cadmium lethality and hepatotoxicity. Toxicol Appl Pharmacol 1995, 135: 222-8.
13. Masters, B.A., Kelly, E.J., Quaife, C.J., Brinster, R.L., Palmiter, R.D. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc Natl Acad Sci 1994, 91: 584-8.
14. Kägi, J.H.R., Kojima, Y. Chemistry and biochemistry of metallothionein. "Metallothionein II" Experientia Supplementum 1987, 52: 25-61.
15. Reports of the surveillance program of health conditions of the students in 1994, Japanese Society of School Health, Hokuto Kogyo Co. Tokyo, 1995.
16. Fassoulaki, A., Eger, E.I. 2nd., Johnson, B.H. et al. Briefperiods of hypoxia can produce hepatic injury in rats. Anesth Analg 1984, 63: 885-7.
17. Kawane, T., Saikatsu, S., Akeno, N., Abe, M., Horiuchi, N., Starvation-induced increase in the parathyroid hormone/PTH-related protein receptor mRNA of bone and kidney in sham-operated and thyroparathyroidectomized rats. Eur J Endocrinol 1997, 137: 273-80.
18. Haider, S., Haleem, D.J. Decreases of brain serotonin following a food restriction schedule of 4 weeks in male and female rats. Medical Science Monitor 2000, 6: 1061-7.
19. Palmiter, R.D. Molecular biology of metallothionein gene expression: "Metallothionein II" Experientia Supplementum 1987, 52: 63-80.
20. Sogawa, N., Sogawa, A.C., Oda, N., Fujioka, T., Onodera, K., Futura, H. Induction of metallothionein mRNA expression in the mouse liver at an early time after cadmium injection measured by the reverse transcriptase-polymerase chain reaction method. Methods Find Exp Clin Pharmacol 2000, 22: 663-6.
21. Sogawa, N., Onodera, K., Sogawa, C.A. et al. Bisphenol A enhances cadmium toxicity through estrogen receptor Methods Find Exp Clin Pharmacol 2001, 23 395-9.
22. Fujioka, T., Sogawa, N., Sogawa, C.A., Oda, N., Furuta, H. Sex difference in expression of metallothionein mRNA in mouse liver after low dose cadmium injection. Jpn J Oral Biol 2001, 43: 83-8.
23. Leber, A.P., Miya, T.S. A mechanism for cadmium- and zinc-induced tolerance to cadmium toxicity: Involvement of metallothionein. Toxicol Appl Pharmacol 1976, 37: 403-14.
24. Onosaka, S., Min, K.S., Fukuhara, C., Tanaka, K. Roles of metallothionein in the liver on acute cadmium toxicity in mice. III. Effects of high concentration of metallothionein. Eisei Kagaku 1985, 31: 133-6.
25. Kershaw, W.C., Iga, T., Klaassen, C.D. Ethanol decreases hepatotoxicity in rats: Possible role of hepatic metallothionein induction. Toxicol Appl Pharmacol 1990, 106: 448-55.