Induction of metallothionein mRNA expression in the mouse liver after cadmium injection as measured by the reverse transcriptasepolymerase chain reaction method

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 22, Issue 9, 2000, Pages 663-666

  Sogawa, N ^a   Sogawa, C A ^a   Oda, N ^a   Fujioka, T ^a   Onodera, K ^a   Furuta, H ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Cadmium; Liver; Metallothionein; mRNA expression; Sex differences

Indexed keywords

CADMIUM; HEAVY METAL; METALLOTHIONEIN;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG LIVER LEVEL; ENZYME INDUCTION; GENE EXPRESSION REGULATION; LIVER PARENCHYMA; MESSENGER RNA SYNTHESIS; METAL BINDING; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RECEPTOR AFFINITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE; SQUAMOUS EPITHELIUM; TISSUE SPECIFICITY;

ANIMALS; CADMIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LIVER; MALE; METALLOTHIONEIN; MICE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0034466945     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2000.22.9.802280     Document Type: Article

References (22)

1. Metallothionein: A cadmium- and zinc-containing protein from equine renal cortex
2. Chemistry and biochemistry of metallothionein. "Metallothionein II."
3. Induced synthesis of metallothionein in various tissues of rats in response to metals. I. Repeated cadmium injection
4. Stimulatory effects of 4-methylcatechol, dopamine and levodopa on the expression of metallothionein-III (GIF) mRNA in immortalized mouse brain glial cells (VR-2g)
5. Constitutive expression of metallothionein genes in mouse brain
6. MT-III, a brain-specific member of the metallothionein gene family
7. Induction of synthesis and degradation of metallothionein-I in the tissues of rats injected with zinc
8. Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia
9. Molecular biology of metallothionein gene expression: "Metallothionein II."
10. Quantification of gene expression over a wide range by the polymerase chain reaction
11. Correlation of hepatic metallothionein concentrations with acute cadmium toxicity in the mouse
12. Transgenic mice that overexpress metallothionein-I are protected from cadmium lethality and hepatotoxicity
13. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium
14. Metallothionein
15. Metallothionein: An intracellular protein to protect against cadmium toxicity
16. Structure of mouse metallothionein-I gene and its mRNA
17. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
18. Sex difference in expression of metallothionein mRNA in mouse liver after Cd injection
19. Studies on "Itai-itai" disease
20. Cadmium-thionein and the protection by cadmium against the nephrotoxicity of mercury
21. Developmental and sex differences in cadmium distribution and metallothionein induction and localization
22. Degradation of rat liver metallothioneins in vitro