A protective role for calcitonin gene-related peptide in water-immersion stress-induced gastric ulcers in rats

Pharmacological Research

Volumn 35, Issue 4, 1997, Pages 347-350

  Evangelista, Stefano ^a,c   Renzi, Daniela ^b  

^a Ist Farmacobiologico Malesci SpA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c Dept of Pharmacology   (Italy)

Author keywords

Calcitonin; Capsaicin; Gene related peptide (CGRP); Water immersion stress (WIS)

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH; STOMACH ULCER; STRESS; SUBCUTANEOUS DRUG ADMINISTRATION; WATER IMMERSION;

EID: 0031126373     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1997.0142     Document Type: Article

References (15)

1. Sternini C, Reeve JR, Brecha N. Distribution and characterization of calcitonin gene-related peptide immunoreactivity in the digestive system of normal and capsaicin-treated rats. Gastroenterology. 93:1987;852-862.
2. Evangelista S, Maggi CA, Giuliani S, Meli A. Further studies on the role of the adrenals in the capsaicin-sensitive 'gastric defence mechanism'. Int J Tiss Res. 10:1988;253-255.
3. Holzer P, Sametz W. Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurons. Gastroenterology. 91:1986;975-981.
4. Holzer P, Lippe ITH. Stimulation of afferent nerve endings by intragastric capsaicin protects against ethanol-induced damage of gastric mucosa. Neuroscience. 27:1988;981-987.
5. Holzer P, Pabst MA, Lippe ITH, Pesker BM, Peskaz BA, Livingston EH, Guth PH. Afferent nerve-mediated protection against deep mucosal damage in the rat stomach. Gastroenterology. 98:1990;838-848.
6. Lippe ITH, Lorbach M, Holzer P. Close arterial infusion of calcitonin gene-related peptide into the rat stomach inhibits aspirin- and ethanol-induced hemorrhagic damage. Reg Pept. 26:1989;35-46.
7. Maggi CA, Evangelista S, Giuliani S, Meli A. Anti-ulcer activity of calcitonin gene-related peptide in rats. Gen Pharmacol. 18:1987;33-34.
8. Dugani AM, Glavin GB. Capsaicin effects on stress pathology and gastric acid secretion in rats. Life Sciences. 39:1986;1531-1538.
9. Geppetti P, Tramontana M, Evangelista S, Renzi D, Maggi CA, Fusco BM, Del Bianco E. Differential effect of neuropeptide release of different concentrations of hydrogen ions on afferent and intrinsic neurons of the rat stomach. Gastroenterology. 101:1991;1505-1511.
10. Esplugues JV, Ramos EG, Gil L, Esplugues J. Influence of capsaicin-sensitive afferent neurones on the acid secretory responses of the rat stomach in vivo. Br J Pharmacol. 100:1990;491-496.
11. Holzer P, Peskar BM, Peskar BA, Amann R. Release of calcitonin gene-related peptide induced by capsaicin in the vascularly perfused rat stomach. Neurosci Lett. 108:1990;195-200.
12. Kitagawa H, Fujiwara M, Osumi Y. Effects of water-immersion stress on gastric secretion and mucosal blood flow in rats. Gastroenterology. 77:1980;298-302.
13. Taché Y, Pappas T, Lauffenburger M, Goto Y, Walsh JH, Debas H. Calcitonin gene-related peptide: potent peripheral inhibitor of gastric acid secretion in rats and dogs. Gastroenterology. 87:1984;344-349.
14. Arai I, Hirose H, Muramatsu M, Aihara H. Effects of restraint and water-immersion stress and insulin on gastric acid secretion in rats. Physiol Behav. 40:1987;357-361.
15. Peskar BM, Lambrecht N, Stroff T, Respondek M, Muller K-M. Functional ablation of sensory neurons impairs healing of acute gastric mucosal damage in rats. Dig Dis Sci. 40:1995;2460-2464.