Up-regulation of inducible nitric oxide synthase mRNA in dogs experimentally infected with Borrelia burgdorferi

Veterinary Immunology and Immunopathology

Volumn 67, Issue 3, 1999, Pages 271-284

  Härter, Luc ^a   Straubinger, Reinhard K ^a   Summers, Brian A ^a   Erb, Hollis N ^a   Appel, Max J G ^a  

^a Coll of Vet Med Cornell Univ ^*  (United States)

Author keywords

Borrelia burgdorferi; Canine; INOS; Lyme disease; RT PCR

Indexed keywords

MESSENGER RNA; NITRIC OXIDE SYNTHASE;

ANIMAL LAMENESS; ANIMAL MODEL; ARTICLE; BORRELIA BURGDORFERI; CONTROLLED STUDY; DOG; ENZYME ACTIVATION; ENZYME INDUCTION; GENE EXPRESSION; GENE SEQUENCE; HISTOPATHOLOGY; LYME DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

ANIMALS; ARTHRITIS, INFECTIOUS; BORRELIA BURGDORFERI GROUP; DOG DISEASES; DOGS; FEMALE; HUMANS; JOINTS; LAMENESS, ANIMAL; LYME DISEASE; MACROPHAGES, ALVEOLAR; MALE; MOLECULAR SEQUENCE DATA; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION;

ACARI; ANIMALIA; BORRELIA; BORRELIA BURGDORFERI; CANIS FAMILIARIS;

EID: 0344492738     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2427(98)00231-1     Document Type: Article

References (21)

1. Adams H.R. Physiologic, pathophysiologic, and therapeutic implications for endogenous nitric oxide. JAVMA. 209:1996;1297-1302.
2. Adler H., Frech B., Thöny M., Pfister H., Peterhans E., Jungi T.W. Inducible nitric oxide in cattle. J. Immunol. 154:1995;4710-4718.
3. Appel M.J.G., Allen S., Jacobson R.H., Lauderdale T.-L., Chang Y.-F., Shin S.J., Thomford J.W., Todhunter R.J., Summers B.A. Experimental Lyme disease in dogs produce arthritis and persistent infection. J. Infect. Dis. 167:1993;651-664.
4. Evans T.J., Buttery L.D.K., Carpenter A., Springall D.R., Polak J.M., Cohen J. Cytokine-treated human neutrophils contain inducible nitric oxide synthase that produces nitration of ingested bacteria. Proc. Natl. Acad. Sci. U.S.A. 93:1996;9553-9558.
5. Garthwaite J., Charles S.L., Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests a role as intracellular messenger in the brain. Nature. 336:1988;385-388.
6. Grabowski P.S., MacPherson H., Ralston S.H. Nitric oxide production in cells derived from human joint. Brit. J. Rheumatol. 35:1996;207-212.
7. James S.L. Role of nitric oxide in parasitic infections. Microbiol. Rev. 59:1995;547-553.
8. Liew F.Y. The role of nitric oxide in parasitic disease. Ann. Trop. Med. Parasitol. 87:1993;637-642.
9. Ma Y., Seiler K.P., Tai K.-F., Yang L., Woods M., Weis J.J. Outer surface lipoproteins of Borrelia burgdorferi stimulate nitric oxide production by the cytokine-inducible pathway. Infect. Immun. 62:1994;3663-3671.
10. McCall T.B., Palmer R.M.J., Moncada S. Introduction of nitric oxide synthase in rat peritoneal neutrophils and its inhibition by dexamethasone. Eur. J. Immunol. 21:1991;2327-2523.
11. McInnes I.B., Leung B.P., Field M., Wei X.Q., Huang F.P., Sturrock R.D., Kinninmonth A., Weidner J., Mumford R., Liew F.Y. Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients. J. Exp. Med. 184:1996;1519-1524.
12. Modolell M., Schaible U.E., Rittig M., Simon M.M. Killing of Borrelia burgdorferi by macrophages is dependent on oxygen radicals and nitric oxide and can be enhanced by antibodies to outer surface proteins of the spirochete. Immunol. Lett. 40:1994;139-146.
13. Nathan C., Hibbs J.B. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr. Opin. Immunol. 3:1991;65-70.
14. Nussler A.K., Billiar T.R. Inflammation, immunregulation, and inducible nitric oxide synthase. J. Leukoc. Biol. 54:1993;171-178.
15. Palmer R.M.J., Ferrige A.G., Moncada S. Nitric oxide release accounts for the biological activity of endothelium derived relaxing factor. Nature. 327:1988;524-526.
16. Schmidt H.H.H.W., Walter U. NO at work. Cell. 78:1994;919-925.
17. Seiler K.P., Vavrin Z., Eichwald E., Hibbs J.B., Weis J.J. Nitric oxide production during murine Lyme disease: Lack of involvement in host resistance or pathology. Infect. Immun. 63:1995;3886-3895.
18. Sigal L.H. Lyme disease: A review of aspects of its immunology and immunopathogenesis. Ann. Rev. Immunol. 15:1997;63-92.
19. Straubinger R.K., Straubinger A.F., Härter L., Jacobson R.H., Chang Y.-F., Summers B.A., Erb H.N., Appel M.J.G. Borrelia burgdorferi migrates into joint capsules and causes an up-regulation of interleukin-8 in synovial membranes of dogs experimentally infected with ticks. Infect. Immun. 65:1997;1273-1285.
20. Tanaka T., Shibasaki F., Ishikawa M., Hirano N., Sakai R., Nishida J., Takenawa T., Hirai H. Molecular cloning of bovine actin-like protein actin 2. Biochem. Biophys. Res. Comm. 187:1992;1022-1028.
21. Ueki Y., Miyake S., Tominaga Y., Eguchi K. Increased nitric oxide levels in patients with rheumatoid arthritis. J. Rheumatol. 23:1996;230-236.