Meta-analysis of clinical trials of Cyclo 3 Fort in the treatment of chronic venous insufficiency

International Angiology

Volumn 22, Issue 3, 2003, Pages 250-262

  Boyle, Peter ^a   Diehm, C ^b   Robertson, C ^c,d  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^d Scottish Centre for Infection and Environmental Health   (United Kingdom)

Author keywords

Cyclo3; Venous insufficiency, diagnosis; Venous insufficiency, therapy

Indexed keywords

ASCORBIC ACID; CHALCONE DERIVATIVE; FABROVEN; HESPERIDIN; PHLEBODRIL; PLACEBO; RUSCUS ACULEATUS EXTRACT;

ADULT; AGED; ANKLE; ARTICLE; CHRONIC DISEASE; CHRONIC VEIN INSUFFICIENCY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HUMAN; LEG EDEMA; LEG ISCHEMIA; LEG PAIN; MALE; MEDICINAL PLANT; META ANALYSIS; MORBIDITY; MUSCLE CRAMP; PARESTHESIA; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; RUSCUS ACULEATUS; SAMPLE SIZE; SYMPTOMATOLOGY; TREATMENT OUTCOME; VARICOSIS;

ADULT; CARDIOVASCULAR AGENTS; CHRONIC DISEASE; HUMANS; PLANT EXTRACTS; TREATMENT OUTCOME; VENOUS INSUFFICIENCY;

EID: 0344465806     PISSN: 03929590     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Nicolaides A. Investigation of chronic venous insufficiency. A consensus statement. Circulation 2000;102:126-63.
2. Carpentier P, Priollet P. Epidémiologie de l'insuffisance veineuse chronique. Presse Méd 1994;23:197-201.
3. Marcelon G, Verbeuren TJ, Lauressergues H, Vanhoutte PM. Effect of Ruscus aculeatus on isolated canine cutaneous veins. Gen Pharmacol 1983;14:103-6.
4. Bouskela E, Cyrino FZ, Marcelon G. Effects of Ruscus extract on the internal diameter of arterioles and venules of the hamster cheek pouch microcirculation. J Cardiovasc Pharmacol 1993;22:221-4.
5. Bouskela E, Cyrino FZ, Marcelon G. Inhibitory effect of the Ruscus extract and of the flavonoid hesperidine methylchalcone on increased microvascular permeability induced by various agents in the hamster cheek pouch. J Cardiovasc Pharmacol 1993;22:225-30.
6. Marcelon G, Vanhoutte P. Venotonic effect of Ruscus under variable temperature conditions in vitro. Phlebology 1988;3:51-4.
7. Bouaziz N, Michiels C, Janssens D, Berna N, Eliaers F, Panconi E et al. Effect of Ruscus extract and hesperidin methylchalcone on hypoxia-induced activation of endothelial cells. Int Angiol 1999;18:306-12.
8. Janssens D, Delaive E, Houbion A, Eliaers F, Remacle J, Michiels C. Effect of venotropic drugs on the respiratory activity of isolated mitochondria and in endothelial cells. Br J Pharmacol 2000;130:1513-24.
9. Haas S, Lill G, Stiller A, Geissdorfer K, Blumel G. Influence of Ruscus extract and methylhesperidine chalcone on the fibrinolytic activity of the vein wall.
10. Basellini B, Agus GB, Losa S, Corsi G, Nicora F. Clinical and experimental assessment of the action of ruscus aculeatus in chronic venous insufficiency. II Congress of Phlebology. November 5-8, 1985, Florence.
11. Cappelli R, Nicora M, Di Perri T. Use of extract of ruscus aculeatus in venous disease in the lower limbs. Drugs Exptl Clin Res 1988;14:277-83.
12. Berg D. Administer antivaricotics at intervals. Artzliche Praxis 1985;37:3462-3.
13. Beltramino RMD, Penenory AMD, Buceta AMD. An open-label, randomized multicenter study comparing the efficacy and safety of Cyclo 3 Fort versus hydroxyethyl rutoside in chronic venous lymphatic insufficiency. Angiology 2000;51:535-44.
14. de Parades B, Demarez JP, Cauquil J. Comparative analysis of the therapeutic effects of Cyclo 3 Fort and Diosmin 450 mg in combination with hesperidin 50 mg in venous insufficiency of the legs. Vie Med 1990;6:1-13.
15. Monteil-Seurin J. Comparative trial of the activity of Cyclo 3 Fort and of Daflon 500 in venolymphatic insufficiency. J Med Pratique 1989;8.
16. Elbaz G, Nebot F, Reiharez D. Double blind study (with "ampoules"). Venous insufficiency of the lower limbs statistical study of the effect of Cyclo 3. Phlebologie 1976;1:83-90.
17. Le Devehat C, Lemoine A, Roux E, Cirette B, Vimeux M, Martinaggi P. Double blind clinical study (with "ampoules"). Clinical and hemodynamic aspects of Cyclo 3 in venous insufficiency. Angiologie 1984;3:119-22.
18. Altenkamper H. Efficacy of antivaricotic drugs can be measured objectively. Phlebologie 1987;2:9-20.
19. Boccalon H. Cyclo 3 Fort and antagonism of plethysmographic disturbances observed upon exposure to heat: preliminary results. Phlebologie 1988;3:59-62.
20. Braun R, Hirche H, Van Laak H-H. Treatment of venous insufficiency: a double-blind trial with phlebodril. Z Allgemeinmed 1985;61:309-13.
21. de Parades B, Cornu Thenard A, Demarez JP. Double-blind placebo-controlled clinical evaluation of the activity of a phlebotonic agent. Material and methods. Phlebologie 1985;613-5.
22. Languillat N, Ladure PH, Magnan de Bornier N, Baillet J. Exploration fonctionnelle de la vitesse circulatoire veineuse grâce au Xénon 133. Gazette Méd 1992;99.
23. Le Devehat C, Khodabandehlou T, Vimeux M, Dougny M. The effects of Cyclo 3 Fort treatment on hemorheological disturbances during a provoked venous stasis in patients with chronic venous insufficiency. Clin Hemorheol 1994;14:s53-s63.
24. Leyh F. Treatment of venous leg ulcers with Ruscus extract and trimethyl hesperidin chalcon. Results of a double-blind study. Therapiewoche 1988;36:2325-31.
25. Lozes A, Boccalon H. Double blind study of Ruscus extract: venous plethysmographic results in man. Int Angiol 1984;3:99-102.
26. Parrado F, Buzzi A. A study of the efficacy and tolerability of a preparation containing ruscus aculeatus in the treatment of chronic venous insufficiency of the lower limbs. Clin Drug Invest 1999;18:255-61.
27. Rieger H. Efficacy of a combination drug in patients with chronic venous insufficiency under orthostatic conditions. Phlebologie 1988;3:127-30.
28. Rudofsky G, Diehm C, Kahle B, Bisler H, Schultz-EHU. Ruscus alcaloid and hesperidin in the treatment of chronic venous insufficiency. 1987.
29. Rudofsky G, Diehm C, Gruss JD, Hartmann M, Schultz-Ehrenburg HK, Bisler H. Chronic venous insufficency. Treatment with Ruscus extract and trimethylhesperidin chalcone. MMW 1990;132:205-10.
30. Sentou Y. Double blind study of the activity of Cyclo 3 in man. Int Angiol 1984;3:106-9.
31. Seydewitz V, Berg D, Staubesand J, Welbers P. Influence of drug treatment on lysosome enzyme activity on the modified vein walls of varicose veins. Phlebologie 1992;21:288-92.
32. Strauss AL, Rieger H. The oedema-protective action of a combination product in an orthostasis test. Phlebologie 1992;21:247-51.
33. Boccalon H, Causse C, Yubero L. Comparative efficacy of a single daily dose of two capsules Cyclo 3 Fort in the morning versus a repeated dose of 1 capsule morning and noon. Int Angiol 1998;17:155-60.
34. Jager K, Eichlisberger R, Jeanneret Ch, Lobs KH. Pharmacodynamic effects of Ruscus extract (Cyclo 3 Fort) on superficial and deep veins in patients with primary varicose veins. Clinl Drug Invest 1999;17:265-73.
35. Kiesewetter H, Blume J, Scheffler P, Gerhards M, Jung F. Clinical efficacy of Cyclo 3 Fort associated with support in chronic venous insufficiency of the legs. Gaz Med 1987;94.
36. Leutenegger E, Martinaggi P. PF 190 and chronic venous insufficiency premarketing multicentre study conducted by specialists (on 886 cases). Gaz Med 1988;13.
37. Hoffmann J. Results of a clinical trial carried out in the federal republic of Germany by 400 general practitionners. Statistical analysis of 2,359 cases. Comptes Rendus de Therapeutique 1982;1:9-19.
38. Hoffmann J, Day UH. Long-term treatment of chronic venous insufficiency. Medwelt 1987;345-8.
39. Pierre Fabre Medicament. Computerized follow-up of phase IV studies - 95% of interpretable cases out of 5,360 patients included in the Cyclo 3 Fort study. Angiologie 1991;8:1949-78.
40. Stram DO. Meta analysis of published data using a linear mixed effects model. Biometrics 1996;52:536-44.
41. Bryk AS, Raudenbush SW. Hierarchical linear models. London: Sage; 1992.
42. Splus 2000 Release 3. 2000. Seattle, Mathsoft Inc.
43. Rasbash J, Browne W, Healy M, Cameron B, Charlton C. MLwiN. 2000. London, Multilevel Models Project, Institute of Education.