A study of the efficacy and tolerability of a preparation containing Ruscus aculeatus in the treatment of chronic venous insufficiency of the lower limbs

Clinical Drug Investigation

Volumn 18, Issue 4, 1999, Pages 255-261

  Parrado, Fátima ^a   Buzzi, Alfredo ^a  

^a HOSPITAL DE CLÍNICAS JOSÉ DE SAN MARTÍN   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; HESPERIDIN; RUSCUS EXTRACT;

ADULT; AGED; ANKLE; ARTICLE; CHRONIC VEIN INSUFFICIENCY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; EPIGASTRIC PAIN; GASTROINTESTINAL SYMPTOM; HEARTBURN; HUMAN; LEG VARICOSIS; MAJOR CLINICAL STUDY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0032708927     PISSN: 11732563     EISSN: None     Source Type: Journal    
DOI: 10.2165/00044011-199918040-00001     Document Type: Article

References (16)

1. Evans CJ, Fowkes FG, Hajivassiliou CA, et al. Epidemiology of varicose veins. A review. Int Angiol 1994; 13 (3): 263-70
2. Cheatle TR, Scurr JH, Coleridge Smith PD. Drug treatment of chronic venous insufficiency and venous ulceration: A review. J R Soc Med 1991 Jun; 84 (6): 354-8
3. Jain KK. Pathophysiology and pharmacotherapy of chronic venous insufficiency: A critical review. J Clin Res 1998; 1: 269-88
4. Jager K, Eichlisberger R, Jeanneret Ch, et al. Pharmacodynamic effects of Ruscus extract (Cyclo 3 Fort®) on superficial and deep veins: Assessment by duplexsonography. Clin Drug Invest 1999; 17 (4): 265-73
5. Bouskela E, Cyrino FZGA, Marcelon G. Effects of Ruscus extract on the internal diameter of arterioles and venules on the hamster cheek pouch microcirculation. J Cardiovasc Pharmacol 1993; 22: 221-4
6. Bouskela E, Cyrino FZGA, Marcelon G. Inhibitory effects of the Ruscus extract and of the flavinoid hesperidine methylchalcone on increased microvascular permeability induced by various agents in the hamster cheek pouch. J Cardiovasc Pharmacol 1993; 22: 225-30
7. Marcelon G, Vanhoutte PM. Venotonic effects of Ruscus under variable temperature conditions in vitro. Phlebology 1988; 3 Suppl. 1: 51-4
8. Boccalon H. Cyclo 3 Fort and antagonism of plethysmographic disturbances observed upon exposure to heat: Preliminary results. Phlebology 1988; 3 Suppl. 1: 59-62
9. Miller VM, Rud K, Gloviezki P. Interactions of Ruscus extract with endothelin receptors in human varicose veins. Clin Hemorheol 1994; 14 Suppl. 1: S37-S34
10. Cappelli R, Nicora M, Di Perri T. Use of extract of Riscus aculeatus in venous disease in the lower limbs. Drugs Exp Clin Res 1988; XIV (4): 277-83
11. Schwab J, et al. Effects of Phlebosdril therapy in chronic venous insufficiency stages I, II and III. In: Maurer PC, editor. What is New in Angiology. Trends and Controversies. Munich/Bern/Vienna: Zuchsherdt, 1986: 242-3
12. Basellini A, Agus GB, Losa S, et al. Valutazione clinico-sperimentale sullázione del Ruscus aculeatus nell insufficienza venosa cronica in: -II Congre. II. Phlebologia. 1985 Nov 5-8, Firenze
13. Holfman J, Braun R. Phlebodril in general practice. A multicentre trial. Int Angiol 1984; 3: 103
14. Demarez JP, Laurent D. European validation of phlebotonics: A summary of French clinical studies demonstrating the activity of Cyclo 3. Phlebology, De. P.M. London: Vanhoutte, John Libbey, 1988; 3 Suppl. 1: 131-2
15. Widmer LK, Plech S-Ch, Leu HJ, et al. Venenkrangungen bei 1800 berufstutigen, baser studie II. Schweiz Med Wochenschr 1967; 97: 107-10
16. Monteil-Seurin J. Venlymphatic insufficiency: Comparative study of Cyclo 3 Fort versus micronized diosmin. C R Thér Pharmacol Clin 1993; 109: 3-7