Single and Double Mutations in gyrA but Not in gyrB Are Associated with Low- and High-Level Fluoroquinolone Resistance in Helicobacter pylori

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 12, 2003, Pages 3942-3944

  Tankovic, Jacques ^a   Lascols, Christine ^b   Sculo, Quentin ^b   Petit, Jean Claude ^a   Soussy, Claude James ^b  

^a HÔPITAL SAINT ANTOINE   (France)

^b HENRI MONDOR HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; CLINAFLOXACIN; GARENOXACIN; GATIFLOXACIN; GEMIFLOXACIN; LEVOFLOXACIN; MOXIFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TROVAFLOXACIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL GENE GYRA; BACTERIAL GENE GYRB; BACTERIAL STRAIN; BACTERIUM MUTANT; CONTROLLED STUDY; GENE MUTATION; HELICOBACTER PYLORI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

ANTI-INFECTIVE AGENTS; DNA GYRASE; DRUG RESISTANCE, BACTERIAL; FLUOROQUINOLONES; FRANCE; GENOTYPE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MUTATION; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0344443197     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.12.3942-3944.2003     Document Type: Article

References (15)

1. Alm, R. A., L. S. Ling, D. T. Moir, B. L. King, E. D. Brown, P. C. Doig, D. R. Smith, B. Noohan, B. C. Guild, B. L. DeJonge, G. Carmel, P. J. Tummino, A. Caruso, M. Uria-Nickelsen, D. M. Mills, C. Ives, R. Gibson, D. Merberg, S. D. Mills, Q. Jiang, D. E. Taylor, G. F. Vovis, and T. J. Trust. 1999. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature 397:176-180.
2. Bina, J. E., R. A. Alm, M. Uria-Nickelsen, S. R. Thomas, T. J. Trust, and R. E. W. Hancock. 2000. Helicobacter pylori uptake and efflux: basis for intrinsic susceptibility to antibiotics in vitro. Antimicrob. Agents Chemother. 44:248-254.
3. Boyanova, L., I. Stancheva, Z. Spassova, N. Katzarov, I. Mitov, and R. Koumanova. 2000. Primary and combined resistance to four antimicrobial agents in Helicobacter pylori in Sofia, Bulgaria. J. Med. Microbiol. 49:415-418.
4. Cabrita, J., M. Oleastro, R. Matos, A. Manhente, J. Cabral, R. Barros, A. I. Lopez, P. Ramalho, B. C. Neves, and A. S. Guerreiro. 2000. Features and trends in Helicobacter pylori antibiotic resistance in Lisbon area, Portugal (1990-1999). J. Antimicrob. Chemother. 46:1029-1031.
5. Cammarota, G., R. Cianci, O. Cannizzaro, L. Cuoco, G. Pirozzi, A. Gasbarrini, A. Armuzzi, M. A. Zocco, L. Santarelli, F. Arancio, and G. Gasbarrini. 2000. Efficacy of two one-week rabeprazole/levofloxacin-based triple therapies for Helicobacter pylori infection. Aliment, Pharmacol. Ther. 14:1339-1343.
6. Comité de l'Antibiogramme de la Société Française de Microbiologie. 2002. Communiqué 2002. Société Française de Microbiologie, Paris, France.
7. Debets-Ossenkop, Y. J., A. J. Herscheid, R. G. J. Pot, E. J. Kuipers, J. G. Kusters, and C. M. J. E. Vandenbroucke-Grauls. 1999. Prevalence of Helicobacter pylori resistance to metronidazole, clarithromycin, amoxicillin, tetracycline and trovafloxacin in The Netherlands. J. Antimicrob. Chemother. 47:511-515.
8. Grignon, B., J. Tankovic, F. Mégraud, Y. Glupczynski, M.-O. Husson, M.-C. Conroy, J.-P. Emond, J. Loulergue, J. Raymond, and J.-L. Fauchère. 2002. Validation of diffusion methods for macrolide susceptibility testing of Helicobacter pylori. Microb. Drug Resist. 8:61-66.
9. Heep, M., M. Kist, S. Strobel, D. Beck, and N. Lehn. 2000. Secondary resistance among 554 isolates of Helicobacter pylori after failure of therapy. Eur. J. Clin. Microbiol. Infect. Dis. 19:538-541.
10. Minehart, H. W., and A. F. Chalker. 2001. In vitro activity of gemifloxacin against Helicobacter pylori. J. Antimicrob. Chemother. 47:360-361.
11. Moore, R. A., B. Beckthold, S. Wong, A. Kureishi, and L. E. Bryan. 1995. Nucleotide sequence of the gyrA gene and characterization of ciprofloxacin-resistant mutants of Helicobacter pylori. Antimicrob. Agents Chemother. 39:107-111.
12. Sanchez, J. E. G., N. G. Saenz, M. R. Rincon, I. T. Martin, E. G. Sanchez, and M. J. F. Martinez. 2000. Susceptibility of Helicobacter pylori to mupirocin, oxazolidinones, quinupristin/dalfopristin and new quinolones. J. Antimicrob. Chemother. 46:283-285.
13. Tomb, J. F., O. R. Kerlavage, R. A. Clayton, G. G. Sutton, R. D. Fleischmann, K. A. Ketchum, H. P. Klenk, S. Gill, B. A. Dougherty, K. Nekson, J. Quackenbush, L. Zhou, E. F. Kirkness, S. Peterson, B. Loftus, D. Richardson, R. Dodson, H. G. Khalak, A. Glodek, K. McKenney, L. M. Fitzgerald, M. Lee, M. D. Adams, J. C. Venter, et al. 1997. The complete gene sequence of the gastric pathogen Helicobacter pylori. Nature 388:539-547.
14. Toro, C., J. Garcia-Samaniego, J. Carbo, A. Iniguez, T. Alarcon, M. Lopez-Brea, and M. Baquero. 2001. Prevalence of primary Helicobacter pylori resistance to eight antimicrobial agents in a hospital in Madrid. Rev. Esp. Quimioter. 14:172-176.
15. Wang, G., T. J. M. Wilson, Q. Jiang, and D. E. Taylor. 2001. Spontaneous mutations that confer antibiotic resistance in Helicobacter pylori. Antimicrob. Agents Chemother. 45:727-733.