The health Canada Great Lakes Multigeneration Study - Summary and regulatory considerations

Regulatory Toxicology and Pharmacology

Volumn 27, Issue 1 II, 1998, Pages

  Mark Feeley, M ^a   Jordan, Scott A ^a   Gilman, Andrew P ^b  

^a HEALTH CANADA   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHLORDANE; DIOXIN; FOOD ADDITIVE; MERCURY; MIREX; POLYCHLORINATED BIPHENYL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; FOOD CONTAMINATION; IMMUNOLOGY; LAKE; NEUROCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAT; REPRODUCTION; RISK ASSESSMENT; SALMON;

ANIMALIA; ONCORHYNCHUS TSHAWYTSCHA; RODENTIA; SIGANUS;

EID: 0344404213     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.1997.1194     Document Type: Article

References (55)

1. Ahlborg, U. G., Hanberg, A., and Kenne, K. (1992). Risk assessment of polychlorinated biphenyls (PCBs), Nordic Council of Ministers, Nord 1992:26.
2. Arnold, D. L., Stapley, R., Bryce, F., and Mahon, D. (1998a). A multigeneration study to ascertain the toxicological effects of Great Lakes salmon fed to rats: Study overview and design. Regul. Toxicol. Pharmacol. 27, 000-000.
3. Arnold, D. L., Bryce, F., Miller, D., Stapley, R., Malcolm, S., and Hayward, S. (1998b). The toxicological effects following the ingestion of chinook salmon from the Great Lakes by Sprague-Dawley rats during a two-generation feeding-reproduction study. Regul. Toxicol. Pharmacol. 27, 000-000.
4. ATSDR (Agency for Toxic Substances and Disease Registry) (1992). Missouri chlordane exposure study: A report on persons who consume chlordane-contaminated fish, PB93-148252.
5. Beattie, M. K., Gerstenberger, S., Hoffman, R., and Dellinger, J. A. (1996). Rodent neurotoxicity bioassays for screening contaminated Great Lakes fish. Environ. Toxicol. Chem. 15(3), 313-318.
6. Boyer, I. J., Kokoski, C. J., and Bolger, P. M. (1991). Role of FDA in establishing tolerable levels for dioxins and PCBs in aquatic organisms. J. Toxicol. Environ. Health 33, 93-101.
7. Caygill, C. P. J., and Hill, M. J. (1995). Fish, n-3 fatty acids and human colorectal and breast cancer mortality. Eur. J. Cancer Prev. 4, 329-332.
8. Chu, I., Villeneuve, D. C., Valli, V. E., Ritter, L., Norstrom, R. J., Ryan, J. J., and Becking, G. C. (1984). Toxicological response and its reversibility in rats fed Lake Ontario or Pacific coho salmon for 13 weeks. Environ. Sci. Health B19(8, 9), 713-731.
9. Crane, J. L. (1996). Carcinogenic human health risks associated with consuming contaminated fish from five Great Lakes areas of concern. J. Great Lakes Res. 22(3), 653-668.
10. Daly, H. B. (1991). Reward reductions found more aversive by rats fed environmentally contaminated salmon. Neurotoxicol. Teratol. 13, 449-453.
11. Dar, E., Kanarek, M. S., Anderson, H. A., and Sonzogni, W. C. (1992). Fish consumption and reproductive outcomes in Green Bay, Wisconsin. Environ. Res. 59, 189-201.
12. Dourson, M. L., and Clark, J. M.(1990). Fish consumption advisories: Toward a unified, scientifically credible approach. Regul. Toxicol. Pharmacol. 12, 161-178.
13. Feeley, M. M., and Grant, D. L. (1993). Approach to risk assessment of dioxins and furans in Canada. Regul. Toxicol. Pharmacol. 18, 428-437.
14. Fein, G. G., Jacobson, J. L., Jacobson, S. W., Schwartz, P. M., and Dowler, J. K. (1984). Prenatal exposure to polychlorinated biphe-nyls: Effects on birth size and gestational age. J. Pediatr. 105, 315-320.
15. Foran, J. A., Cox, M., and Croxton, D. (1989). Sport fish consumption advisories and projected cancer risks in the Great Lakes basin. Am. J. Public Health 79(3), 322-325.
16. Foster, W. G., Jarrell, J. F., YoungLai, E.V., Wade, M. G., Arnold, D. L., and Jordan, S. A. (1996). An overview of some reproductive toxicology studies conducted at Health Canada. Toxicol. Ind. Health 12(3-4), 447-459.
17. Gladen, B. C., and Rogan, W. J. (1991). Effects of perinatal polychlorinated biphenyls and dichlorodiphenyl dichloroethene on later development. J. Pediatr. 119, 58-63.
18. Gossett, R., Wikholm, G., Ljubenkov, J., and Steinman, D. (1989). Human serum DDT levels related to consumption of fish from the coastal waters of Los Angeles. Environ. Toxicol. Chem. 8, 951-955.
19. Grant, D. L. (1983). Regulation of PCBs in Canada. In PCBs: Human and Environmental Hazards (F. M. D'Itri and M. A. Kamrin, Eds.), pp. 383-392. Butterworth, Boston.
20. Great Lakes Water Quality Board (1991). Cleaning Up Our Great Lakes: A Report from the Water Quality Board to the International Joint Commission on Toxic Substances in the Great Lakes Basin Ecosystem. International Joint Commission, Windsor, Ontario.
21. Hagmar, L., Linden, K., Nilsson, A., Norrving, B., Äkesson, B., SchÜtz, A., and Möller, T. (1992). Cancer incidence and mortality among Swedish Baltic Sea fishermen. Scand. J. Work Environ. Health 18, 217-224.
22. Hagmar, L., Hallberg, T., Leja, M., Nilsson, A., and Schütz, A. (1995). High consumption of fatty fish from the Baltic Sea is associated with changes in human lymphocyte subset levels. Toxicol. Lett. 77, 335-342.
23. Hertzler, D. R. (1990). Neurotoxic behavioral effects of Lake Ontario salmon diets in rats. Neurotoxicol. Teratol. 12, 139-143.
24. Hovinga, M. E., Sowerrs, M., and Humphrey, H. E. B. (1993). Environmental exposure and lifestyle predictors of lead, cadmium, PCB and DDT levels in Great Lakes fish eaters. Arch. Environ. Health 48(2), 98-104.
25. Humphrey, H. E. B. (1987). The human population - An ultimate receptor for aquatic contaminants. Hydrobiologia. 149, 75-80.
26. Iverson, F., Mehta, R., Hierlihy, L., Gurofsky, S., Lok, E., Mueller, R., Bourbonnais, D. H., and Spear, P. A. (1998). Microsomal enzyme activity, glutathione S-transferase-placental form expression, cell proliferation, and vitamin A stores in livers of rats consuming Great Lakes salmon. Regul. Toxicol. Pharmacol. 27, S76-S89.
27. Jacobson, J. L., and Jacobson, S. W. (1996). Intellectual impairment in children exposed to polychlorinated biphenyls in utero. New Engl. J. Med. 335, 783-789.
28. Jacobson, J. L., and Jacobson, S. W. (1997). Teratogen update: Polychlorinated biphenyls. Teratology 55, 338-347.
29. Kreiss, K. (1985). Studies on populations exposed to polychlorinated biphenyls. Environ. Health Perspect. 60, 193-199.
30. Levy, S. M., Herberman, R. B., Lee, J., Whiteside, T., Beadle, M., Heiden, L., and Simons, A. (1991). Persistently low natural killer cell activity, age and environmental stress as predictors of infectious morbidity. Nat. Immun. Cell Growth Regul. 10, 289-307.
31. Lonky, E., Reihman, J., Darvill, T., Mather, J., Sr., and Daly, H. (1996). Neonatal behavioral assessment scale performance in humans influenced by maternal consumption of environmentally contaminated Lake Ontario fish. J. Great Lakes Res. 22(2), 198-212.
32. Mumtaz, M. M., Sipes, I. G., Clewell, H. J., and Yang, R. S. H. (1993). Risk assessment of chemical mixtures: Biologic and toxicological issues. Fundam. Appl. Toxicol. 21, 258-269.
33. Newsome, W. H., Andrews, P., Conacher, H. B. S., Rao, R. R., and Chatt, A. (1993). Total organochlorine content of fish from the Great Lakes. J. AOAC Int. 76(4), 703-706.
34. Olsen, S. F., Sørensen, J. D., Secher, N. J., Hedegaard, M., Henriksen, T. B., Hansen, H. S., and Grant, A. (1992). Randomised controlled trial of effect offish-oil supplementation on pregnancy duration. Lancet. 339(8800), 1003-1007.
35. Ontario Ministry of Environment and Energy (1993). The results of the 1992 "Guide to Eating Ontario Sport Fish," Publication PIBS 2593E.
36. Pappas, B. A., Murtha, S. J. E., Park, G. A. S., Hewitt, K., Seegal, R. F., and Jordan, S. A. (1998). Neurobehavioral effects of chronic ingestion of Great Lakes chinook salmon. Regul. Toxicol. Pharmacol. 27, 000-000.
37. Pellettieri, M. B., Hallenbeck, W. H., Brenniman, G. R., Cailas, M., and Clark, M. (1996). PCB intake from sport fishing along the northern Illinois shore of Lake Michigan. Bull. Environ. Contam. Toxicol. 57, 766-770.
38. Philips, D. J. H. (1990). Food for thought: Fish, fats and fate. Marine Poll. Bull. 21(2), 56-59.
39. Rogan, W. J., Gladen, B. C., McKinney, J. D., Carreras, N., Hardy, P., Thullen, J., Tingelstad, J., and Tully, M. (1987). Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: Effects on growth, morbidity, and duration of lactation. Am. J. Public Health 77, 1294-1297.
40. Rylander, L., Strömberg, U., and Hagmar, L. (1995). Decreased birthweight among infants born to women with high dietary intake of fish contaminated with persistent organochlorine compounds. Scand. J. Work Environ. Health 21, 368-375.
41. Schantz, S. (1996). Developmental neurotoxicity of PCBs in humans: What do we know and where do we go from here? Neurotoxicol. Teratol. 18(3), 217-227.
42. Schwartz, G. G. (1997). Multiple myeloma: Clusters, clues and dioxins. Cancer Epidemiol. Biomark. Prev. 6(1), 49-56.
43. Seegal, R. F., Pappas, B. A., and Park, G. A. S. (1998). Neurochemical effects of consumption of Great Lakes salmon by rats. Regul. Toxicol. Pharmacol. 27, S68-S75.
44. Sexton, K., and Reiter, L. W. (1989). Health research at the U.S. Environmental Protection Agency. Environ. Sci. Technol. 23, 917-924.
45. Shubat, P. J., Raatz, K. A., and Olson, R. A. (1996). Fish consumption advisories and outreach programs for southeast Asian immigrants. Toxicol. Ind. Health 12(3-4), 427-434.
46. Smith, B. J. (1984). PCB levels in human fluids: Sheboygan case study, Technical Report WIS-SG-83-240. University of Wisconsin Sea Grant Institute.
47. Svensson, B. G., Nilsson, A., Hansson, M., Rappe, C., Åkesson, B., and Skerfving, S. (1991). Exposure to dioxins and dibenzofurans through the consumption offish. New Engl. J. Med. 324, 8-12.
48. Swain, W. R. (1991). Effects of organochlorine chemicals on the re-productive outcome of humans who consumed contaminated Great Lakes fish: An epidemiologic consideration. J. Toxicol. Environ. Health 33, 587-639.
49. Svensson, B. G., Hallberg, T., Nilsson, A., Schutz, A., and Hagmar, L. (1994). Parameters of immunological competence in subjects with high consumption of fish contaminated with persistent organochlorine compounds. Int. Arch. Occup. Environ. Health 65(6), 351-358.
50. Svensson, B. G., Nilsson, A., Jonsson, E., Schutz, A., Akesson, B., and Hagmar, L. (1995). Fish consumption and exposure to persistent organochlorine compounds, mercury, selenium and methylamines among Swedish fishermen. Scand. J. Work Environ. Health 21(2), 96-105.
51. Svensson, B. G., Mikoczy, Z., Stromberg, U., and Hagmar, L. (1995). Mortality and cancer incidence among Swedish fishermen with a high dietary intake of persistent organochlorine compounds. Scand. J. Work Environ. Health 21(2), 106-115.
52. Tryphonas, H., McGuire, P., Fernie, S., Miller, D., Stapley, R., Bryce, F., Arnold, D. L., and Fournier, M. (1998a). Effects of Great Lakes fish consumption on the immune system of Sprague-Dawley rats investigated during a two-generation reproductive study. I. Body and organ weights, food consumption, and hematological parameters. Regul. Toxicol. Pharmacol. 27, S28-S39.
53. Tryphonas, H., Fournier, M., Lacroix, F., McGuire, P., Hayward, S., Bryce, F., Flipo, D., and Arnold, D. L. (1998b). Effects of Great Lakes fish consumption on the immune system of Sprague-Dawley rats investigated during a two-generation reproductive study. II. Quantitative and functional aspects. Regul. Toxicol. Pharmacol. 27, S40-S54.
54. Villeneuve, D. C., Valli, V. E., Norstrom, R. J., Freeman, H., Sanglang, G. B., Ritter, L., and Becking, G. C. (1981). Toxicological response of rats fed Lake Ontario or Pacific coho salmon for 28 days. J. Environ. Sci. Health B16(6), 649-689.
55. Yamashita, N., Maruyama, M., Yamazaki, K., Hamazaki, T., and Yano, S. (1991). Effect of eicosapentaenoic and docoahexaenoic acid on natural killer cell activity in human peripheral blood lymphocytes. Clin. Immunol. Immunopathol. 59, 335-345.