Expression of matrix metalloproteinase 9 (MMP-9/gelatinase B) in adenocarcinomas strongly correlated with expression of immune response genes

In Silico Biology

Volumn 3, Issue 3, 2003, Pages 301-311

  Creighton, Chad ^a   Hanash, Samir ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Data mining; Immune response; Matrix metalloproteinases; Microarrays; MMP9

Indexed keywords

ALPHA1 COLLAGEN TYPE 4; ALPHA2 COLLAGEN TYPE 4; ALPHA2 COLLAGEN TYPE 5; ALPHA2 COLLAGEN TYPE 6; BETA2 INTEGRIN; CD53 ANTIGEN; CD68 ANTIGEN; CONNECTIVE TISSUE GROWTH FACTOR; ENTACTIN; FIBULIN 1; FIBULIN 2; GELATINASE A; GELATINASE B; GELSOLIN LIKE CAPPING PROTEIN; IMMUNOGLOBULIN E FC FRAGMENT; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN 1; INTERLEUKIN 2 RECEPTOR GAMMA; INTERLEUKIN 7 RECEPTOR; L SELECTIN; LUMICAN; LYMPHOCYTE SPECIFIC PROTEIN 1; MESSENGER RNA; NEUTROPHIL CYTOSOLIC FACTOR 4; PERLECAN; PROTEIN; THROMBOSPONDIN 1; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERSICAN;

ARTICLE; COLON ADENOCARCINOMA; CONTROLLED STUDY; CORRELATION FUNCTION; DATA BASE; DNA MICROARRAY; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNE SYSTEM; LUNG ADENOCARCINOMA; OVARY ADENOCARCINOMA; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR IMMUNITY;

ADENOCARCINOMA; GENE EXPRESSION PROFILING; HUMANS; IMMUNITY; LUNG; MATRIX METALLOPROTEINASE 9; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TUMOR ESCAPE;

EID: 0344308475     PISSN: 13866338     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Egeblad, M. and Werb, A. (2002). New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. Cancer 2, 161-174.
2. Overall, C. M. and Lopez-Otin, C. (2002). Strategies for MMP inhibition in cancer: Innovations for the post-trial era. Nat. Rev. Cancer 2, 657-672.
3. Opdenakker, G., van den Steen, P. E., Dubois, B., Nelissen, I., van Coillie, E., Masure, S., Proost, P. and van Damme, J. (2001). Gelatinase B functions as regulator and effector in leukocyte biology. J. Leukoc. Biol. 69, 851-859.
4. Opdenakker, G., van den Steen, P. E. and van Damme, J. (2001). Gelatinase B: A tuner and amplifier of immune functions. Trends Immunol. 22, 571-579.
5. Schönbeck, U., Mach, F. and Libby, P. (1998). Generation of biologically active IL-1 beta by matrix metalloproteinases: A novel caspase-1-independent pathway of IL-1 beta processing. J. Immunol. 161, 3340-3346.
6. Pruijt, J. F., Fibbe, W. E., Laterveer, L., Pieters, R. A., Lindley, I. J., Paemen, L., Masure, S., Willemze, R. and Opdenakker, G. (1999). Prevention of interleukin-8-induced mobilization of hematopoietic progenitor cells in rhesus monkeys by inhibitory antibodies against the metalloproteinase gelatinase B (MMP-9). Proc. Natl. Acad. Sci. USA 96, 10863-10868.
7. Proost, P., van Damme, J. and Opdenakker, G. (1993). Leukocyte gelatinase B cleavage releases encephalitogens from human myelin basic protein. Biochem. Biophys. Res. Commun. 192, 1175-1181.
8. Dubois, B., Masure, S., Hurtenbach, U., Paemen, L., Heremans, H., van den Oord, J., Sciot, R., Meinhardt, T., Hammerling, G., Opdenakker, G. and Arnold, B. (1999). Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions. J. Clin. Invest. 104, 1507-1515
9. Beer, D. G., Kardia, S. L., Huang, C. C., Giordano, T. J., Levin, A. M., Misek, D. E., Lin, L., Chen, G., Gharib, T. G., Thomas, D. G., Lizyness, M. L., Kuick, R., Hayasaka, S., Taylor, J. M., Iannettoni, M. D., Orringer, M. B. and Hanash, S. (2002). Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat. Med. 8, 816-824.
10. Bhattacharjee, A., Richards, W. G., Staunton, J., Li, C., Monti, S., Vasa, P., Ladd, C., Beheshti, J., Bueno, R., Gillette, M., Loda, M., Weber, G., Mark, E. J., Lander, E. S., Wong, W., Johnson, B. E., Golub, T. R., Sugarbaker, D. J. and Meyerson, M. (2001). Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc. Natl. Acad. Sci. USA 98, 13790-13795.
11. Garber, M. E., Troyanskaya, O. G., Schluens, K., Petersen, S., Thaesler, Z., Pacyna-Gengelbach, M., Van De Rijn, M., Rosen, G. D., Perou, C. M., Whyte, R. I., Altman, R. B., Brown, P. O., Botstein, D. and Petersen, I. (2001). Diversity of gene expression in adenocarcinoma of the lung. Proc. Natl. Acad. Sci. USA 98, 13784-13789.
12. Giordano, T. J., Shedden, K. A., Schwartz, D. R., Kuick, R., Taylor, J. M., Lee, N., Misek, D. E., Greenson, J. K., Kardia, S. L., Beer, D. G., Rennert, G., Cho, K. R., Gruber, S. B., Fearon, E. R. and Hanash, S. (2001). Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles. Am. J. Pathol. 159, 1231-1238.
13. Spellman, P. T. and Rubin, G. M. (2002). Evidence for large domains of similarly expressed genes in the Drosophila genome. J. Biol. 1, 5.
14. Creighton, C., Beer, D. and Hanash, S. (2003). Gene expression patterns define pathways correlated with loss of differentiation in lung adenocarcinomas. FEBS Lett. (in press).
15. Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., Harris, M. A., Hill, D. P., Issel-Tarver, L., Kasarskis, A., Lewi, S., Matese, J. C., Richardson, J. E., Ringwald, M., Rubin, G. M. and Sherlock, G. (2000). Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium. Nat. Genet. 25, 25-29.
16. Pruitt, K. D. and Maglott, D. R. (2001). RefSeq and LocusLink: NCBI gene-centered resources. Nucleic Acids Res. 29, 137-140.
17. Supplementary web site for "Expression of matrix metalloproteinase 9 (MMP-9/gelatinase B) strongly correlated with expression of immune response genes in lung adenocarcinomas". [http://dot.ped.med.umich.edu:2000/pub/mmp/index.htm].
18. Hammani, K., Blakis, A., Morsette, D., Bowcock, A. M., Schmutte, C., Henriet, P. and DeClerk, Y. A. (1996). Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene. J. Biol. Chem. 271, 25498-25505.
19. Yang, Z., Kyriakides, T. R. and Bornstein, P. (2000). Matricellular proteins as modulators of cell-matrix interactions: Adhesive defect in thrombospondin 2-null fibroblasts is a consequence of increased levels of matrix metalloproteinase-2. Mol. Biol. Cell. 11, 3353-3364.
20. Fan, W. H. and Karnovsky, M. J. (2002). Increased MMP-2 expression in connective tissue growth factor over-expression vascular smooth muscle cells. J. Biol. Chem. 277, 9800-9805.
21. Allan, J. A., Docherty, A. J., Barker, P. J., Huskisson, N. S., Reynolds, J. J. and Murphy, G. (1995). Binding of gelatinases A and B to type-I collagen and other matrix components. Biochem. J. 309, 299-306.
22. Rosenberg, G. A. (2002). Matrix metalloproteinases in neuroinflammation. Glia 39, 279-291.
23. Masys, D. R., Welsh, J. B., Lynn Fink, J., Gribskov, M., Klacansky, I. and Corbeil, J. (2001). Use of keyword hierarchies to interpret gene expression patterns. Bioinformatics 17, 319-326.
24. Pollack, J. R., Sorlie, T., Perou, C. M., Rees, C. A., Jeffrey, S. S., Lonning, P. E., Tibshirani, R., Botstein, D., Borresen-Dale, A. L. and Brown, P. O. (2002). Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors. Proc. Natl. Acad. Sci. USA 12963-12968.
25. Fiore, E., Fusco, C., Romero, P. and Stamenkovic, I. (2002). Matrix metalloproteinase 9 (MMP-9/gelatinase B) proteolytically cleaves ICAM-1 and participates in tumor cell resistance to natural killer cell-mediated cytotoxicity. Oncogene 21, 5213-5223.