Genetic and Environmental Effects on Offspring Alcoholism: New Insights Using an Offspring-of-Twins Design

Archives of General Psychiatry

Volumn 60, Issue 12, 2003, Pages 1265-1272

  Jacob, Theodore ^a   Waterman, Brian ^b   Heath, Andrew ^c   True, William ^d   Bucholz, Kathleen K ^c   Haber, Randy ^a   Scherrer, Jeff ^d   Fu, Qiang ^d  

^a VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d SAINT LOUIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL;

ADOLESCENT; ADULT; ALCOHOLISM; ARTICLE; CONTROLLED STUDY; DIZYGOTIC TWINS; ENVIRONMENTAL FACTOR; GENETIC RISK; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOZYGOTIC TWINS; PROGENY; PSYCHOLOGIC TEST; SCHOOL CHILD; TWINS;

ADOLESCENT; ADULT; ALCOHOLISM; CHILD; CHILD OF IMPAIRED PARENTS; DISEASES IN TWINS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIKELIHOOD FUNCTIONS; MALE; MIDDLE AGED; RISK ASSESSMENT; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 0344305506     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.60.12.1265     Document Type: Article

References (58)

1. McGue M. A behavioral-genetic perspective on children of alcoholics. Alcohol Health Res World. 1997;21:210-217.
2. Sher KJ. Psychological characteristics of children of alcoholics. Alcohol Health Res World. 1997;21:247-254.
3. Sher KJ. Children of Alcoholics: A Critical Appraisal of Theory and Research. Chicago, Ill: University of Chicago Press; 1991.
4. Windle M. Concepts and issues in COA research. Alcohol Health Res World. 1997;21:185-191.
5. Windle M, Searles J. Children of Alcoholics: Critical Perspectives. New York, NY: Guilford Publications; 1990.
6. Jacob TJ, Sher K, Bucholz KK, True WT, Sirevaag EJ, Rohrbaugh J, Nelson E, Neuman RJ, Todd RD, Slutske WS, Whitfield JB, Kirk K, Martin NG, Madden PAF, Heath AC. An integrative approach for studying the etiology of alcoholism and other addictions. Twin Res. 2001;4:103-118.
7. Jacob T, Leonard K. Family and peer influences in the development of adolescent alcohol abuse. In: Zucker R, Boyd G, Howard J, eds. Development of Alcohol Problems: Exploring the Biopsychosocial Matrix of Risk. Washington, DC: National Institute on Alcohol Abuse and Alcoholism; 1994.
8. Ellis DA, Zucker RA, Fitzgerald HE. The role of family influences in development and risk. Alcohol Health Res World. 1997;21:218-226.
9. Heath AC, Slutske WS, Madden PAF. Gender differences in the genetic contribution to alcoholism risk and to alcohol consumption patterns. In: Wilsnack RW, Wilsnack SC, eds. Gender and Alcohol. Rutgers, NJ: Rutgers University Press; 1997.
10. Johnson S, Jacob T. Psychosocial functioning in children of alcoholic fathers. Psychol Addict Behav. 1995;9:101-113.
11. Chassin L, Barrera M. Substance use escalation and substance use restraint among adolescent children of alcoholics. Psychol Addict Behav. 1993;7:3-20.
12. Jacob T, Windle M. Young adult children of alcoholic, depressed and nondistressed parents. J Stud Alcohol. 2000;61:836-844.
13. Newcomb MD, Felix-Ortiz M. Multiple protective and risk factors for drug use and abuse: cross-sectional and prospective findings. J Pers Soc Psychol. 1992;63:280-296.
14. Sher KJ, Trull TJ. Methodological issues in psychopathology research. Annu Rev Psyhol. 1996;47:371-400.
15. Zucker RA, Fitzgerald HE, Moses HD. Emergence of alcohol problems and the several alcoholisms: a developmental perspective on etiologic theory and life course trajectory. In: Cicchetti D, Cohen DJ, eds. Developmental Psychopathology: Risk, Disorder, and Adaptation. Vol 2. New York, NY: John Wiley & Sons Inc; 1995:677-711.
16. Heath AC. Genetic influences on alcoholism risk? a review of adoption and twin studies. Alcohol Health Res World. 1995;19:166-171.
17. Eaves LJ, Silberg JL, Meyer JM, Maes HH, Simonoff E, Pickles A, Rutter M, Reynolds CA, Heath AC, Truett KR, Neale MC, Erikson MT, Loeber R, Hewitt JK. Genetics and developmental psychopathology, 2: the main effects of genes and environment on behavioral problems in the Virginia Twin Study of Adolescent Behavior Development. J Child Psychol Psychiatry. 1997;38:965-980.
18. Stoolmiller M. Implications of restricted range of family environments for estimates of heritability and nonshared environment in behavior-genetic adoption studies. Psychol Bull. 1999;125:392-409.
19. Bouchard TJ, Pederson N. Twins reared apart: nature's double experiment. In: LaBuda MC, Grigorenko EL, eds. On the Way to Individuality: Current Methodological Issues in Behavioral Genetics. Hungtington, NY: Nova Science Publishers; 1999:71-93.
20. Gottesman II, Bertelsen A. Confirming unexpressed genotypes for schizophrenia. Arch Gen Psychiatry. 1989;46:867-872.
21. Heath AC, Kendler KS, Eaves LJ, Markell D. The resolution of cultural and biological inheritance: informativeness of different relationships. Behav Genet. 1985;15:439-465.
22. Nance WE, Corey LA. Genetic models for the analysis of data from the families of identical twins. Genetics. 1976;83:811-826.
23. Rutter M, Pickles A, Murray R, Eaves L. Testing hypotheses on specific environmental causal effects on behavior. Psychol Bull. 2001;127:291-324.
24. Jacob T. Family studies of alcoholism. J Fam Psychol. 1992;5:319-338.
25. Steinglass P, Bennett LA, Wolin SJ, Reiss D. The Alcoholic Family. New York, NY: Basic Books Inc Publishers; 1987.
26. VanOers JA, Bongers IM, VanDeGoor LA, Gerresten HF. Alcohol consumption, alcohol-related problems, problem drinking, and socioeconomic status. Alcohol Alcohol. 1999;34:78-88.
27. Bucholz KK, Heath AC, Madden PAF. Transitions in drinking in adolescent females: evidence from the Missouri adolescent female twin study. Alcohol Clin Exp Res. 2000;24:914-923.
28. Bucholz KK, Heath AC, Reich T, Hesselbrock VM, Kramer JR, Nurnberger JI, Schuckit MA. Can we subtype alcoholics? a latent class analysis of data from relatives of alcoholics in a multicenter family study of alcoholism. Alcohol Clin Exp Res. 1996;20:1462-1471.
29. Jackson KM, Sher KJ, Wood PK. Trajectories of concurrent substance use disorders: a developmental, typological approach to comorbidity. Alcohol Clin Exp Res. 2000;24:902-913.
30. Eisen S,True W, Goldberg J, Henderson W, Robinette CD. The Vietnam Era Twin (VET) Registry: method of construction. Acta Genet Med Gemellol (Roma). 1987;36:61-67.
31. Henderson WG, Eisen S, Goldberg J, True W, Barnes JE, Vitek ME. The Vietnam Era Twin Registry: a resource for medical research. Public Health Rep. 1990;105:368-373.
32. Eisen SA, Goldberg J, True WR, Henderson WR. A co-twin control study of the effects of the Vietnam War on the current physical health of veterans. Am J Epidemiol 1991;134:49-58.
33. Tsuang MT, Lyons MJ, Eisen S, Goldberg J, True W, Meyer J, Eaves L. Genetic influences on DSM-III-R drug abuse and dependence drugs: a study of 3,372 twin pairs. Am J Med Genet. 1996;67:473-477.
34. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition. Washington, DC: American Psychiatric Association; 1987.
35. Bucholz KK, Cadoret R, Cloninger CR, Dinwiddie SH, Hesselbrock VM, Nurnberger JI, Reich T, Schmidt I, Schuckit MA. A new, semi-structured psychiatric interview for use in genetic linkage studies: a report of the reliability of the SSAGA. J Stud Alcohol. 1994;55:149-158.
36. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC: American Psychiatric Association; 1994.
37. Skinner HH, Sheu WJ. Reliability of alcohol use indices: Lifetime Drinking History and MAST. J Stud Alcohol. 1982;43:1157-1170.
38. Stata Corp. Stata Statistical Software. College Station, Tex: Stata Corp; 2001.
39. Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ. The lifetime history of major depression in women: reliability of diagnosis and heritability. Arch Gen Psychiatry. 1993;50:863-870.
40. Neale MC, Maes HH. Methodology for Genetic Studies of Twins and Families. Dordrecht, the Netherlands: Kluwer Academic Publishers; 2000.
41. Heath AC, Nelson EC. Towards a molecular epidemiology of alcohol dependence: the importance of genotype x environment interaction effects. Alcohol Res Health. 2002;26:193-201.
42. Searles JS. The role of genetics in the pathogenesis of alcoholism. J Abnorm Psychol. 1988;97:153-167.
43. Stoolmiller M. Correcting estimates of shared envrionmental variance for range restriction in adoption studies using a truncated multivariate normal model. Behav Genet. 1998;28:429-441.
44. Cotton NS. The familial incidence of alcoholism: a review. J Stud Alcohol. 1979;40:89-116.
45. Elliot CN, Heath AC, Madden PAF, Cooper ML, Dinwiddie SH, Bucholz KK, Glowinski A, McLaughlin T, Dunne MP, Statham DJ, Martin NG. Association between self-reported childhood sexual abuse and adverse psychosocial outcomes. Arch Gen Psychiatry. 2002;59:139-145.
46. Eaves LJ, Last KA, Martin NG, Jinks JL. A Progressive approach to non-additivity and genotype-environmental covariance in the analysis of human differences. Br J Math Stat Psychol. 1977;30:1-42.
47. Kendler KS, Heath AC, Neale MC, Kessler RC, Eaves LJ. A population-based twin study of alcoholism in women. JAMA. 1992;268:1877-1882.
48. Prescott CA, Aggen SH, Kendler KS. Sex differences in the sources of genetic liability to alcohol abuse and dependence in a population-based sample of US twins Alcohol Clin Exp Res. 1999;23:1136-1144.
49. Heath AC, Bucholz KK, Madden PAF, Dinwiddle SH, Slutske WS, Statham DJ, Dunne MP, Whitfield J, Martin NG. Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychol Med. 1997;27:1381-1396.
50. True WR, Xian H, Scherrer JF, Madden PAF, Bucholz KK, Heath AC, Eisen SA, Lyons MJ, Goldberg J, Tsuang M. Common genetic vulnerability for nicotine and alcohol dependence in men. Arch Gen Psychiatry. 1999;56:655-661.
51. Cadoret R, Troughton E, Woodworth G. Evidence of heterogeneity of genetic effect in Iowa adoption studies. Ann N Y Acad Sci. 1994;708:59-71.
52. Cloninger CR, Bohman M, Sigvardsson S. Inheritance of alcohol abuse: cross-fostering analysis of adopted men. Arch Gen Psychiatry. 1981:38:861-868.
53. Sigvardsson S, Bohman M, Cloninger CR. Replication of the Stockholm Adoption Study of alcoholism: confirmatory cross-fostering analysis. Arch Gen Psychiatry. 1996;53:681-687.
54. Cloninger CR, Bohman M, Sigvardsson S, Von Knorring AL. Psychopathology in adopted-out children of alcoholics: the Stockholm Adoption Study. Recent Dev Alcohol. 1985;3:37-51.
55. Johnston LD, O'Malley PM, Bachman JG. National Survey Results on Drug Use From the Monitoring the Future Study. 1975-1997: Volume II: College Students and Young Adults. Rockville, Md: National Institute on Drug Abuse; 1998.
56. Muthen BO, Muthen LK. The development of heavy drinking and alcohol related problems from ages 18 to 37 in a US national sample. J Stud Alcohol. 2000;61:290-300.
57. Schulenburg J, Wadsworth KM, O'Malley PM, Bachman JG, Johnston LD. Adolescent risk factors for binge drinking during the transition to young adulthood: variable- and pattern-centered approaches to change. Dev Psychol. 1996;32:659-674.
58. Jackson KM, Sher KJ, Gotham HJ, Wood PK. Transitioning into and out of large-effect drinking in young adulthood. J Abnorm Psychol 2001;110:378-391.