Treatment with the NO-synthase inhibitor, methylene blue, moderates the decrease in serum leptin concentration in streptozotocin-induced diabetes

Endocrine Research

Volumn 25, Issue 2, 1999, Pages 163-171

  Haluzik, M ^a   Nedvidkova J ^b   Skrha J ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b INSTITUTE OF ENDOCRINOLOGY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOSYLATED HEMOGLOBIN; LEPTIN; METHYLENE BLUE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; WEIGHT REDUCTION;

EID: 0344299046     PISSN: 07435800     EISSN: None     Source Type: Journal    
DOI: 10.1080/07435809909066138     Document Type: Article

References (16)

1. Zhang Y., Proenca R., Maffei M, Barone M, Leopold L, Friedman JM. 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-32
2. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S. 1995 Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1: 1155-61.
3. Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Henry R, Mudaliar SR, Olefsky J, Caro JF. 1996 Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro. Diabetes 45:699-701.
4. Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J. 1995 Transient increase in obese gene expression after food intake or insulin administration. Nature 377:527-9.
5. Barr VA, Malide D, Zamowski MJ, Taylor SI, Cushman SW. 1997 Insulin stimulates both leptin secretion and production by rat white adipose tissue. Endocrinology 138:4463-72.
6. Ishida K, Murakami T, Mizuno A, Iida M, Kuwajima M, Shima K. 1997 Leptin suppresses basal insulin secretion from rat pancreatic islets. Regul Pept 70:179-82.
7. Patel BK, Koenig JI, Kaplan LM, Hooi SC. 1998 Increase in plasma leptin and Lep mRNA concentrations by food intake is dependent on insulin. Metabolism Clin Exper 47:603-607.
8. Havel PJ, Uriu-Hare JY, Liu T, Stenhope KL, Stem JS, Keen CL, Ahren B. 1998 Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: reversal by insulin. Am J Phys 43: RI 482-9 1.
9. Sivitz WI, Walsh S, Morgan D, Donohoue P, Haynes W, Leibel RL. 1998 Plasma leptin in diabetic and insulin treated diabetic and normal rats. Metabolism Clin Exper 47: 584-591.
10. Catanzaro OL, Marina-Prendes MG, Hope SI, Zuccolo A, Dimingues A. 1994 Streptozotocin-induced hyperglycaemia is decreased by nitric oxide inhibition. Braz J Med Biol Res 27: 2043-7.
11. Gonzalez; E, Rosello-Catafau J, Xaus C, Jawerbaurn A, Novaro V, Gomez G, Gelpi E, Gimeno MA. 1997 Influence of nitric oxide synthase and kinin antagonists on metabolic parameters in chronic streptozotocin-induced diabetes mellitus. Prostaglandins 53:321-36.
12. Kolb H, Kiesel U, Kröncke KD, Kolb-Bachofen V. 1991 Suppression of low dose streptozotocin-induced diabetes in mice by administration of a nitric oxide synthase inhibitor. Life Sci 49:213-7.
13. Haluzik M, Nedvídková J, Škrha 1 1998 The influence of NO-synthase inhibitor and free radicals scavenger - methylene blue - on streptozotocin-induced diabetes in rats. Phys. Res. 47: 337-41.
14. Haluzik M. 1997 Methylene blue - the new effects of an old drug, The thyroid gland, clinical and experimental. 1: 7-13.
15. Widjaja A, Stratton IM, Horn R, Holman RF, Turner R, Brabant G. 1997 UKPDS 20: plasma leptin, obesity, and plasma insulin in type 2 diabetic subjects. J Clin Endocrinol Metab 82:654-7.
16. Mayer B, Brunner F, Schmidt K. 1993 Novel actions of methylene blue. Eur Heart J 14: Suppl. 122-26.