Recombinant factor VIII SQ - The influence of formulation parameters on structure and surface adsorption

International Journal of Pharmaceutics

Volumn 194, Issue 1, 2000, Pages 69-79

  Fatouros, Angelica ^a   Sjöström, Brita ^a  

^a PFIZER INC   (United States)

Author keywords

CD; Conformation; Factor VIII; Metal ions; Protein stability; Surface tension

Indexed keywords

METAL ION; RECOMBINANT BLOOD CLOTTING FACTOR 8;

ARTICLE; CHEMICAL INTERACTION; CIRCULAR DICHROISM; DRUG ACTIVITY; DRUG ADSORPTION; DRUG FORMULATION; DRUG STABILITY; DRUG STRUCTURE; NONHUMAN; PH; PRIORITY JOURNAL; SURFACE TENSION; THERMOSTABILITY;

ADSORPTION; ANIMALS; CATIONS, DIVALENT; CHO CELLS; CIRCULAR DICHROISM; CRICETINAE; DRUG STABILITY; FACTOR VIII; GLASS; HYDROGEN-ION CONCENTRATION; POLYSORBATES; PROTEIN CONFORMATION; PROTEIN DENATURATION; RECOMBINANT PROTEINS; SURFACE PROPERTIES; SURFACE TENSION; SURFACE-ACTIVE AGENTS; TEMPERATURE;

EID: 0344286524     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00369-5     Document Type: Article

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