Azathioprine pharmacogenetics: The relationship between 6-thioguanine nucleotides and thiopurine methyltransferase in patients after heart and kidney transplantation

European Journal of Clinical Chemistry and Clinical Biochemistry

Volumn 34, Issue 3, 1996, Pages 199-205

  Schütz, Ekkehard ^a   Gummert, Jan ^a   Armstrong, Victor William ^a  

^a Zentrum Innere Medizin   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN A; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NUCLEOTIDE; TACROLIMUS; THIOPURINE METHYLTRANSFERASE; TIOGUANINE; XANTHINE OXIDASE;

ALLELE; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; ENZYME ACTIVITY; ERYTHROCYTE; HEART TRANSPLANTATION; HETEROZYGOTE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMOZYGOTE; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; PATIENT MONITORING; PHARMACOGENETICS; PHENOTYPE; PRIORITY JOURNAL; RADIOENZYMATIC ASSAY;

AZATHIOPRINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA; ERYTHROCYTES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GUANINE NUCLEOTIDES; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; METHYLTRANSFERASES; PHARMACOGENETICS; POLYMORPHISM, GENETIC; RADIOIMMUNOASSAY; THIONUCLEOTIDES; XANTHINE OXIDASE;

EID: 0029932094     PISSN: 09394974     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Elion G. Biochemistry and pharmacology of purine analogues. Fed Proc 1967; 26:898-903.
2. Kelley WN, Rosenbloom FM, Seegmiller JE. Effects of azathioprine on purine synthesis in clinical disorders of purine metabolism. J Clin Invest 1967; 46:1518-29.
3. Tidd DM, Paterson ARP. A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine. Cancer Res 1974; 34:738-46.
4. Elion GB. The purine path to chemotherapy. Science 1989; 244:41-53.
5. Lennard E, Eilleyman JS, Van Loon J, Weinshilboum RM. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia. Eancet 1990; 336:225-9.
6. Evans WE, Horner MH, Chu YQ, Kalwinsky D, Roberts WM. Altered mercaptopurine metabolism, toxic effects and dosage requirements in a thiopurine methyltransferase-deficient child with acute lymphatic leukemia. J Pediatr 1991; 119:985-9.
7. Lennard L, Rees CA, Lilleyman JS, Maddocks JL. Childhood leukemia: a relationship between intracellular 6-mercaptopurine metabolites and neutropenia. Br J Clin Pharmacol 1983; 16:359-63.
8. Lennard L, Brown CB, Fox M, Maddocks JL. Azathioprine metabolism in kidney transplant recipients. Br J Clin Pharmacol 1984; 18:693-700.
9. Bergan S, Rugstad HE, Bentdal O, Stokke O. Monitoring of azathioprine treatment by determination of 6-thioguanine nucleotide concentrations in erythrocytes. Transplantation 1994; 58:803-8.
10. Schütz E, Gummert J, Mohr FW, Armstrong VW, Oellerich M. Should 6-thioguanine nucleotides be monitored in heart transplant recipients given azathioprine? Ther Drug Monit. In press.
11. Weinshilboum RM, Sladek SL. Mercaptopurine pharmacogenetics: monogenetic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980; 32:651 62.
12. Tinel M, Berson A, Pessayre D, Letteron P, Cattoni MP, Horsmans Y, Larrey D. Pharmacogenetics of human erythrocyte thiopurine methyltransferase activity in a French population. Br J Clin Pharmacol 1991; 32:729-34.
13. McLeod HL, Lin J-S, Pui C-H, Scott EP, Evans WE. Thiopurine methyltransferase activity in American white and black subjects. Clin Pharmacol Ther 1994; 55:15-20.
14. Vuchetich JP, Weinsbhilboum RM, Price RA. Segregation analysis of human red blood cell thiopurine methyltransferase activity. Genetic Epidemiology 1995; 12:1 -11.
15. Szumlanski CL, Honchel R, Scott MC, Weinshilboum RM. Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes. Pharmacogenetics 1992; 2:148 -59.
16. Van Loon J, Weinshilboum RM. Thiopurine methyltransferase biochemical genetics: human lymphocyte activity. Biochem Genet 1982; 20:637-58.
17. Van Loon J, Weinshilboum RM. Thiopurine methyltransferase isozymes in renal tissue. Drug Metab Dispos 1990; 18:632-8.
18. Krynetski EY, Schuetz JD, Galpin AJ, Pui C-H, Relling MV, Evans WE. A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase. Proc Natl Acad SciUSA 1995; 92:949-53.
19. Otterness DM, Szumlanski CL, Lennard L, Weinshilboum RA. Human thiopurine methyltransferase pharmacogenetics: molecular basis for common genetic polymorphism [abstract]. ISSXProc 1995; 8:107.
20. Ohlman S, Lafolie P, Lindholm A, Lilliemark J, Tyden G, Peterson C. Large interindividual variability in bioavailability of azathioprine in renal transplant recipients. Clin Transplantation 1993; 7:65-70.
21. Bergan S, Rugstad HE, Bentdal O, Endresea L, Stokke O. Kinetics of mercaptopurine and thioguanine nucleotides in renal transplant recipients during azathioprine treatment. Ther Drug Monit 1994; 16:13-20.
22. McLeod HL, Relling MV, Liu Q, Pui C-H, Evans WE. Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia. Blood 1995; 85:1897-902.
23. Lennard L, Van Loon JA, Lilleyman JS, Weinshilboum RM. Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations. Clin Pharmacol Ther 1987; 41:18-25.
24. Weinshilboum RM, Raymond FA, Pazmino PA. Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties. Clin Chim Acta 1978; 85:323 -33.
25. Lennard L. Assay of 6-thioinosinic acid and 6-thioguanine nucleotides, active metabolites of 6-mercaptopurine, in human red blood cells. J Chromatogr 1987; 423:169-78.
26. Burton N, Barnett M, Aherne G, Evans J, Douglas I, Lister A. The effect of food on the oral administration of 6-mercaptopurine. Cancer Chemother Pharmacol 1986; 18:90-1.
27. Schütz E, Gummert J, Mohr FW, Oellerich M. Azathioprineinduced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient. Lancet 1993; 341:436.