The functions of the N terminus of the φX174 internal scaffolding protein, a protein encoded in an overlapping reading frame in a two scaffolding protein system

Journal of Molecular Biology

Volumn 335, Issue 1, 2004, Pages 383-390

  Novak, Christopher R ^a,b   Fane, Bentley A ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b APPLIED BIOSYSTEMS   (United States)

Author keywords

Morphogenesis; Procapsid; Scaffolding protein; X174

Indexed keywords

COAT PROTEIN; INTERNAL SCEFFOLDING PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIOPHAGE; BIOCHEMISTRY; CONFORMATIONAL TRANSITION; GENE DELETION; GENETIC ANALYSIS; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 0344255643     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2003.09.050     Document Type: Article

References (30)

1. Fane, B. A. & Prevelige, P. E., Jr (2003). Scaffolding mediated morphogenesis. In Advances in Protein Chemistry (Johnson, J. & Chui, W., eds). vol. 64, pp. 259-299.
2. Burch, A. D. & Fane, B. A. (2003). Genetic analyses of putative conformation switching and cross-species inhibitory domains in Microviridae external scaffolding proteins. Virology, 310, 64-71. .
3. Siden E.J., Hayashi M. Role of gene B product in bacteriophage φX174 development. J. Mol. Biol. 89:1974;1-16.
4. Tonegawa S., Hayashi M. Intermediates in the assembly of φX174. J. Mol. Biol. 48:1970;219-242.
5. Dokland T., McKenna R., Ilag L.L., Bowen B.R., Incardona N.L., Fane B.A., Rossmann M.G. Structure of a viral assembly intermediate with molecular scaffolding. Nature. 389:1997;308-313.
6. Fujisawa H., Hayashi M. Functions of gene C and gene D products of bacteriophage φX174. J. Virol. 21:1977;506-515.
7. Ekechukwu M.C., Oberste D.J., Fane B.A. Host and φX174 mutations which affect the morphogenesis or stabilization of the 50 S complex, a single stranded DNA synthesizing intermediate. Genetics. 140:1995;1167-1174.
8. Fujisawa H., Hayashi M. Two infectious forms of bacteriophage φX174. J. Virol. 23:1977;439-442.
9. Bernal R.A., Hafenstein S., Olson N.H., Bowman V.D., Chipman P.R., Baker T.S., et al. Structural studies of bacteriophage alpha3 assembly. J. Mol. Biol. 325:2003;11-24.
10. Spindler K.R., Hayashi M. DNA synthesis in Escherichia coli cells infected with gene H mutants of bacteriophage φX174. J. Virol. 29:1979;973-982.
11. Dokland T., Bernal R.A., Burch A.D., Pletnev S., Fane B.A., Rossman M.G. The role of scaffolding proteins in the assembly of the small, single-stranded DNA virus φX174. J. Mol. Biol. 288:1999;595-608.
12. Burch A.D., Ta J., Fane B.A. Cross-functional analysis of the Microviridae internal scaffolding proteins. J. Mol. Biol. 286:1999;95-104.
13. Burch A.D., Fane B.A. Efficient complementation by chimeric Microviridae internal scaffolding proteins is a function of the COOH terminus of the encoded protein. Virology. 270:2000;286-290.
14. Winston F., Botstein D., Miller J.H. Characterization of amber and ochre suppressors in Salmonella typhimurium. J. Bacteriol. 137:1979;433-439.
15. Ekechukwu M.C., Fane B.A. Characterization of the morphogenetic defects conferred by cold-sensitive prohead accessory and scaffolding proteins of φX174. J. Bacteriol. 177:1995;829-830.
16. Fane B.A., Hayashi M. Second-site suppressors of a cold-sensitive prohead accessory protein of bacteriophage φX174. Genetics. 128:1991;663-671.
17. Burch A.D., Fane B.A. Foreign and chimeric external scaffolding proteins as inhibitors of Microviridae morphogenesis. J. Virol. 74:2000;9347-9352.
18. Leibowitz J., Horowitz M.S. Synthesis and assembly of adenovirus polypeptides. III. Reversible inhibition of hexon assembly in adenovirus type 5 temperature-sensitive mutants. Virology. 66:1975;10-24.
19. O'Callaghan D.J., Kemp M.C., Randall C.C. Properties of nucleocapsid species isolated from an in vivo herpes virus infection. J. Gen. Virol. 37:1977;585-594.
20. Prevelige P.E., Thomas D., King J. Scaffolding protein regulates the polymerization of P22 subunits into icosahedral shells in vitro. J. Mol. Biol. 202:1988;743-757.
21. Greene B., King J. Scaffolding mutants identifying domains required for P22 procapsid assembly and maturation. Virology. 225:1996;82-96.
22. Tessmann E.S., Peterson P.K. Bacterial rep-mutations that block development of small DNA bacteriophage late in infection. J. Virol. 20:1976;400-412.
23. Valentine C.R., Montgomery B.A., Miller S.G., Delongchamp R.R., Fane B.A., Malling H.V. Characterization of mutant spectra generated by a forward mutational assay for gene A of φX174 from enu-treated transgenic mouse embryonic cell line PX-2. Environ. Mol. Mutagen. 39:2002;55-68.
24. Colasanti J., Denhardt D.T. Mechanism of replication of bacteriophage φX174. XXII Site-specific mutagenesis of the A* gene reveals that A* protein is not essential for φX174 DNA replication. J. Mol. Biol. 197:1987;47-57.
25. Tessman E.S., Tessman I., Pollock T.J. Gene K of bacteriophage φX174 encodes a nonessential protein. J. Virol. 33:1980;557-560.
26. Dalphin M.E., Fane B.A., Skidmore M.O., Hayashi M. Proteolysis of the bacteriophage φX174 prohead accessory protein gpB by Escherichia coli ompT protease is not essential for phage maturation in vivo. J. Bacteriol. 174:1992;2402-2406.
27. Fane B.A., Head S., Hayashi M. The functional relationship between the J proteins of bacteriophages φX174 and G4 during phage morphogenesis. J. Bacteriol. 174:1992;2717-2719.
28. Roof W.D., Horne S.M., Young K.D., Young R. SlyD, a host gene required for φX174 lysis, is related to the FK506-binding protein family of peptidyl-prolyl cis-trans-isomerases. J. Biol. Chem. 269:1994;2902-2910.
29. Fane B.A., Shien S., Hayashi M. Second-site suppressors of a cold sensitive external scaffolding protein of bacteriophage φX174. Genetics. 134:1993;1003-1011.
30. Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning. 1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.