Late disappearance of hepatitis C virus RNA from peripheral blood mononuclear cells in patients with chronic hepatitis C in sustained response after α-interferon therapy

American Journal of Gastroenterology

Volumn 94, Issue 7, 1999, Pages 1902-1905

  García Bengoechea, Manuel ^a   Basaras, Miren ^b   Barrio, Jesus ^a   Arrese, Elisabet ^b   Montalvo, Inmaculada I ^a   Arenas, Juan I ^a   Cisterna, Ramon ^a  

^a Hospital Arantzazu   (Spain)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; VIRUS RNA;

ADULT; AGED; ARTICLE; CHRONIC HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNOTHERAPY; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; RNA ANALYSIS; VIRUS REPLICATION;

EID: 0344241998     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9270(99)00283-X     Document Type: Article

References (24)

1. Houghton M., Weiner A., Han J., et al. Molecular biology of the hepatitis C viruses: Implications for diagnosis, development and control of viral diseases. Hepatology. 14:1991;381-388.
2. Di Bisceglie A.M., Goodman Z.D., Ishak K.G., et al. Long-term clinical and histopathological follow-up of chronic posttransfusion hepatitis. Hepatology. 14:1991;969-974.
3. Hoofnagle J.H., Di Bisceglie A.M. The treatment of chronic viral hepatitis. N Engl J Med. 336:1997;347-356.
4. Conjeevaram H.S., Everhart J.E., Hoofnagle J.H. Predictors of a sustained beneficial response to interferon alfa therapy in chronic hepatitis C. Hepatology. 22:1995;1326-1329.
5. Martinot-Peignoux M., Marcellin P., Pouteau M., et al. Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alfa therapy in chronic hepatitis C. Hepatology. 22:1995;1050-1056.
6. Simmonds P., Mellor J., Craxi A., et al. Epidemiological, clinical and therapeutic associations of hepatitis C types in western European patients. J Hepatol. 24:1996;517-524.
7. Qian Ch, Camps J., Maluenda M., et al. Replication of hepatitis C virus in peripheral blood mononuclear cells. Effect of alpha-interferon therapy. J Hepatol. 16:1992;380-383.
8. Chomcyznski P., Sacchi N. Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:1987;156-159.
9. Imberti L., Cariani E., Bettinardi A., et al. An inmunoassay for specific amplified HCV sequences. J Virol Methods. 34:1991;233-243.
10. Kwok S., Higuchi R. Avoiding false positive with PCR. Nature. 339:1989;237-238.
11. Saleh M.G., Tibbs C.J., Koskinas J., et al. Hepatic and extrahepatic hepatitis C virus replication in relation to response to interferon therapy. Hepatology. 20:1994;1399-1404.
12. Muratori L., Giostra F., Cataleta M., et al. Testing for hepatitis C virus sequences in peripheral blood mononuclear cells of patients with chronic hepatitis C in absence of serum hepatitis C virus RNA. Liver. 14:1994;124-128.
13. Basaras M., De Las Heras B., García-Bengoechea M., et al. Detection of hepatitis C virus RNA in serum and peripheral blood mononuclear cells in patients with chronic hepatitis C treated with interferon alpha. Eur J Clin Microbiol Infect Dis. 11:1996;887-890.
14. Lanford R.E., Chavez D., Vonchisari F., et al. Lack of detection of negative-strand hepatitis C virus RNA in peripheral mononuclear cells and other extrahepatic tissues by the highly strand-specific rTth reverse transcriptase PCR. J Virol. 69:1995;8079-8083.
15. Mellor J., Haydon G., Blair C., et al. Low level or absent in vivo replication of hepatitis C virus and hepatitis G virus /GB virus C in peripheral blood mononuclear cells. J Gen Virol. 79:1998;705-714.
16. Gil B., Qian Ch, Riezu-Boj J., et al. Hepatic and extrahepatic HCV RNA strands in chronic hepatitis C: Different patterns of response to interferon treatment. Hepatology. 18:1993;1050-1054.
17. Taliami G., Badoleto M.C., Lecce R., et al. Hepatitis C virus RNA in peripheral blood mononuclear cells: Relation with response to interferon treatment. J Med Virology. 47:1995;16-22.
18. Berenguer M., Olaso V., Córdoba J., et al. Genome detection in liver and peripheral blood mononuclear cells: Predictor factors of sustained response in patients with chronic hepatitis C. Eur J Gastroenterol Hepatol. 7:1995;899-903.
19. Castillo I., Bartolomé J., Navas S., et al. Virological and biochemical long-term follow-up of patients with chronic hepatitis C treated with interferon. Hepatology. 19:1994;1342-1346.
20. Balart L.A., Perrillo R., Roddenberry J., et al. Hepatitis C RNA in liver of chronic hepatitis C patients before and after interferon alfa treatment. Gastroenterology. 104:1993;1472-1477.
21. Di Bisceglie A.M., Hoofnagle J.H., Krawczynski K. Changes in hepatitis C virus antigen in liver with antiviral therapy. Gastroenterology. 105:1993;858-862.
22. González-Peralta R.P., Fang J.W.S., Davis G.L., et al. Significance of hepatic expression of hepatitis C viral antigens in chronic hepatitis C. Dig Dis Sci. 40:1995;2595-2601.
23. Kao J.H., Chen P.J., Lai M.Y., et al. Positive and negative strand of hepatitis C virus RNA sequences in peripheral blood mononuclear cells in patients with chronic hepatitis C: No correlation with viral genotypes 1b, 2a and 2b. J Med Virol. 52:1997;270-274.
24. Shindo M., Di Bisceglie A.M., Cheung L., et al. Decrease in serum hepatitis C viral RNA during alpha-interferon therapy for chronic hepatitis. Ann Intern Med. 115:1991;700-704.