Detection of hepatitis C virus RNA in serum and peripheral blood mononuclear cells in patients with chronic hepatitis C treated with interferon alpha

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 15, Issue 11, 1996, Pages 887-890

  Basaras, M ^a   De Las Heras, B ^b   Garcia Bengoechea M ^c   Gallego, L ^a   Arrese, E ^a   Cisterna, R ^a,b  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b HOSPITAL DE BASURTO   (Spain)

^c Hospital Nuestra Senora de Aranzazu   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT ALPHA2A INTERFERON; VIRUS RNA;

ADULT; ARTICLE; CHRONIC HEPATITIS; CLINICAL ARTICLE; CLINICAL TRIAL; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; MALE; MONONUCLEAR CELL; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; RELAPSE; SUBCUTANEOUS DRUG ADMINISTRATION; VIRUS DETECTION; VIRUS REACTIVATION;

EID: 0029751230     PISSN: 09349723     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01691225     Document Type: Article

References (16)

1. Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M: Isolation of a cDNA clone derived from a blood borne non-A, non-B hepatitis genome. Science 1989, 244: 359-362.
2. Chambers TJ, Hahn CS, Galler R, Rice CM: Flavivirus genome organization, expression, and replication. Annual Reviews of Microbiology 1990, 44: 649-688.
3. Wang JT, Sheu JC, Lin JT, Wang TH, Chen DS: Detection of replicative form of hepatitis C RNA in peripheral blood mononuclear cells. Journal of Infectious Diseases 1992, 166: 1167-1169.
4. Bouffard P, Hayashi PH, Acevedo R, Levy N, Zeldis JB: Hepatitis C virus is detected in a monocyte/macrophage subpopulation of peripheral blood mononuclear cells of infected patients. Journal of Infectious Diseases 1992, 166: 1276-1280.
5. Fong TL, Shindo M, Feinstone SM, Hoofnagle JH, Di Bisceglie AM: Detection of replicative intermediates of hepatitis C viral RNA in liver and serum of patients with chronic hepatitis C. Journal of Clinical Investigation 1991, 88: 1058-1060.
6. Zignego AL, Macchia D, Monti M, Thiers V, Massetti M, Foschi M, Maggi E, Romagnani S, Gentilini P, Bréchot C: Infection of peripheral blood mononuclear cells by hepatitis C virus. Journal of Hepatology 1992, 15: 382-386.
7. Davis GL, Balart LA, Schiff ER, Lindsay K, Bodenheimer HC, Perrillo RP, Carey W: Treatment of chronic hepatitis C with recombinant interferon alpha: a multicenter randomized, controlled trial. New England Journal of Medicine 1989, 321: 1501-1506.
8. Di Bisceglie AM, Martin P, Kassianides C, Lisker-Melman M, Murray L, Waggoner JG, Goodman Z: Recombinant interferon alpha therapy for chronic hepatitis C: a randomized, double-blind, placebo-controlled trial. New England Journal of Medicine 1989, 321: 1506-1510.
9. Chomcyznski P, Sacchi N: Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry 1987, 162: 156-159.
10. Imberti L, Cariani E, Bettinardi A, Zonaro A, Albertini A, Primi D: An immunoassay for specific amplified HCV sequences. Journal of Virological Methods 1991, 34: 233-243.
11. Kwok S, Higuchi R: Avoiding false positive with PCR. Nature 1989, 339: 237-238.
12. Gil B, Qian C, Riezu-Boj JI, Civeira MR Prieto J: Hepatic and extrahepatic HCV RNA strands in chronic hepatitis C: different patterns of response to interferon treatment. Hepatology 1993, 18: 1050-1054.
13. Muratori L, Giostra F, Cataleta M, Francesconi R, Ballardini G, Cassani F, Lenzi M, Blanchi FB: Testing for hepatitis C virus sequences in peripheral blood mononuclear cells of patients with chronic hepatitis C in the absence of serum hepatitis C virus RNA. Liver 1994, 14: 124-128.
14. Shindo M, Arai K, Sokawa Y, Okuno T: Hepatic hepatitis C virus RNA as a predictor of a long-term response to interferon-α therapy. Annals of Internal Medicine 1995, 122: 586-591.
15. Ounanian A, Gueddah N, Rolachon A, Thelu MA, Zarski JP, Seigneurin JM: Hepatitis C virus RNA in plasma and blood mononuclear cells in patients with chronic hepatitis C treated with alpha-interferon. Journal of Medical Virology 1995, 45: 141-145.
16. Saleh MG, Tibbs CJ, Koskinas J, Pereira LMMB, Bomford AB, Portmann BC, McFarlane IG, Williams R: Hepatic and extrahepatic hepatitis C virus replication in relation to response to interferon therapy. Hepatology 1994, 20: 1399-1404.