Host defense against bacterial keratitis

Ocular Immunology and Inflammation

Volumn 11, Issue 3, 2003, Pages 171-181

  O'Callaghan, Richard J ^a,c,d   Girgis, Dalia O ^a   Dajcs, Joseph J ^a   Sloop, Gregory D ^b  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LSU EYE CENTER   (United States)

^d LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Antibody; Keratitis; PLA2; Staphylococcus aureus; Tear film

Indexed keywords

ALPHA TOXIN; PHOSPHOLIPASE A2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; CORNEA INJURY; ENZYME ACTIVITY; HOST RESISTANCE; KERATITIS; LACRIMAL FLUID; NONHUMAN; RABBIT; STAPHYLOCOCCUS AUREUS;

ANIMALS; ARACHIDONIC ACID; CORNEAL STROMA; CORNEAL ULCER; EYE INFECTIONS, BACTERIAL; IMMUNITY, NATURAL; IMMUNIZATION; PHOSPHOLIPASE C; PHOSPHOLIPASES A; RABBITS; SPERMIDINE; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TEARS;

EID: 0344197469     PISSN: 09273948     EISSN: None     Source Type: Journal    
DOI: 10.1076/ocii.11.3.171.17351     Document Type: Article

References (15)

1. Mather R, Karenchak LM, Romanowski EG, et al. Fourth generation fluoroquinolones: new weapons in the arsenal of ophthalmic antibiotics. Am J Ophthalmol. 2002;133:463-466.
2. Abel R, Abel A. Perioperative antibiotic, steroidal, and nonsteroidal anti-inflammatory agents in cataract intraocular lens surgery. Curr Opin Ophthalmol. 1996;1:39-42.
3. Hume EBH, Dajcs JJ, Moreau JM, et al. Staphylococcus corneal virulence in a new topical model of infection. Invest Ophthalmol Vis Sci. 2001;42:2904-2908.
4. 2 in rabbit tears: a host defense against Staphylococcus aureus. Invest Ophthalmol Vis Sci. 2001;42:2347-2354.
5. 2 activity in normal and Staphylococcus aureus-infected rabbit eyes. Invest Ophthalmol Vis Sci. [In press] 2003.
6. Weinrauch Y, Elsbach P, Masen LM, et al. The potent anti-Staphylococcus aureus activity of sterile rabbit inflammatory fluid is due to 14-kD phospholipase A2. J Clin Invest. 1996;97:250-257.
7. 2 against grossly clumped Staphylococcus aureus. Infect Immun. 1999;67:2299-2305.
8. 2 is the principal bactericide for staphylococci and other gram-positive bacteria in human tears. Infect Immun. 1998;66: 2791-2797.
9. O'Callaghan RJ, Callegan MC, Moreau JM, et al. Specific roles of alpha-toxin and beta-toxin during Staphylococcus aureus corneal infection. Infect Immun. 1997;65: 1571-1578.
10. O'Callaghan RJ, Engel LS, Hill JM. The rabbit intrastromal infection model of bacterial keratitis. In: Zak O, Sande M, editors. Handbook of animal models of infection. London: Academic Press, 1999;367-374.
11. Callegan MC, Engel LS, Hill JM, et al. Corneal virulence of Staphylococcus aureus: roles of alpha-toxin and protein A in pathogenesis. Infect Immun. 1994;62: 2478-2482.
12. Sloop GD, Moreau JM, Conerly LL, et al. Acute inflammation of the eyelid and cornea in Staphylococcus keratitis in the rabbit. Invest Ophthalmol Vis Sci. 1999;40:385-391.
13. Tan KO, Sack RA, Holden BA, et al. Temporal sequences of changes in tear film composition during sleep. Curr Eye Res. 1993;12:1001-1007.
14. Dajcs JJ, Austin ME, Sloop GD, et al. The corneal pathogenesis of Staphylococcus aureus strain Newman. Invest Ophthalmol Vis Sci. 2002;43:1109-1115.
15. 2 in granules and secrete active enzyme in response to soluble stimuli. Biochim Biophys Res Commun. 1995;208: 650-656.