Combination chemotherapy and photodynamic therapy with N-(2- hydroxypropyl)methacrylamide copolymer-bound anticancer drugs inhibit human ovarian carcinoma heterotransplanted in nude mice

Cancer Research

Volumn 56, Issue 17, 1996, Pages 3980-3985

  Peterson, C Matthew ^a,b,c   Lu, Jing Ming ^d   Sun, Yongren ^a,b   Peterson, C Anthony ^a   Shiah, Jane Guo ^b   Straight, Richard C ^a,b,c   Kopeček, Jindřich ^b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d CHINA MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER;

ANIMAL MODEL; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER TRANSPLANTATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUDE MOUSE; OVARY CARCINOMA; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; XENOTRANSPLANTATION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL DIVISION; DOXORUBICIN; DRUG CARRIERS; FEMALE; HUMANS; METHACRYLATES; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; OVARIAN NEOPLASMS; PHOTOCHEMOTHERAPY; PORPHYRINS; RADIATION-SENSITIZING AGENTS; TRANSPLANTATION, HETEROLOGOUS;

EID: 9444268102     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Bristow, M R., Billingham, M E., Masson, J W., and Daniels, J. R. Clinical spectrum of anthracycline antibiotic cardiotoxicity Cancer Treat. Rep., 62: 873-878, 1978
2. Lefrak, E A., Pitha, J., Rosenheim, S., O'Bryan, R. M., Burgess, M. A., and Gottlieb J A. Adriamycin (NSC 123127) cardiomyopathy. Cancer Chemother. Rep , 6: 203-208, 1975.
3. Bodley, A. L , and Liu, L. F. Topoisomerases as novel targets for cancer chemotherapy Biotechnology, 6: 1315-1319, 1988.
4. Denny, W. A. DNA-intercalating ligands as anticancer drugs prospects for future design Anti-Cancer Drug Des., 4: 241-249, 1989.
5. Ogura, R , Sugiyama, M., Haramaki, N., and Hidaka, T Electron spin resonance studies on the mechanism of Adriamycin-induced heart mitochondrial damages. Cancer Res , 51: 3555-3558, 1991.
6. Kopeček, J. Biodegradation of polymers for biomedical use. In: H. Benoit and P. Rempp (eds.), IUPAC Macromolecules, pp., 305-320 Oxford, United Kingdom: Pergamon Press, 1982
7. Kopeček, J, Rejmanová, P., Strohalm, J., Ulbrich, K., Říhová, B., Chytrý, V., Lloyd, J B., and Duncan, R. Targetable polymeric drugs. US patent 5,037,883, August 6, 1991
8. Rejmanová, P., Pohl, J., Baudyš, M., Kostka, V., and Kopeček, J. Polymers containing enzymatically degradable bonds. 8. Degradation of oligopeptide sequences in N-(2-hydroxypropyl)methacrylamide copolymers by bovine spleen cathepsin B. Makromol Chem., 184: 2009-2020, 1983.
9. Putnam, D., and Kopeček, J. Polymer conjugates with anticancer activity Adv Polym. Sci., 122: 55-122, 1992.
10. Seymour, L W , Ulbrich, K., Strohalm, J., Kopeček, J., and Duncan. R. The pharmacokinetics of polymer-bound Adriamycin. Biochem Pharmacol., 39: 1125-1131, 1990
11. 6) in human ovarian epithelial carcinoma (OVCAR-3) in vitro. J Soc. Gynecol. Invest. 2: 772-777, 1995
12. Brophy, P F., and Keller, S. M. Adriamycin enhanced in vitro and in vivo photodynamic therapy of mesothelioma. J. Surg. Res., 52: 631-634, 1992.
13. Peterson, C. M , Reed, R., Jolles, C J., Jones, K. P., Straight R. C., and Poulson, A. M. Photodynamic therapy of human ovarian epithelial carcinoma OVCAR-3, heterotransplanted in the nude mouse. Am. J. Obstet. Gynecol., 767: 1852-1855, 1992
14. Chaplin, D J. The effect of photodynamic therapy on tumor vascular function. Int. J Radiat. Biol., 60: 311-325, 1991.
15. Feyh, J., Goetz, A., Heiman, A., Konigsberger, R , and Kastenbauer, E. Microcirculatory effects of photodynamic therapy with hematoporphyrin derivative. LaryngoRhino-Otol , 70: 99-101, 1991.
16. Moan, J Porphyrin-sensitized photodynamic inactivation of cells: a review. Lasers Med Sci , 1: 5-12, 1986.
17. Kennedy, J. C., Nadeau, P., Petryka, Z. J., Pottier, R. H., and Weagle, G Clearance times of porphyrin derivatives from mice as measured by in vivo fluorescence spectroscopy. Photochem. Photobiol, 55: 729-734, 1992
18. Kopeček, J. The potential of water-soluble polymeric carriers in targeted and site-specific drug delivery. J Controlled Release, 6: 315-327, 1990
19. Rfhová, B , Bilej, M , Větvička, V., Ulbrich, K., Strohalm, J., Kopeček, J , and Duncan. R Biocompatibitity of N-(2-hydroxypropyl)methacrylamide copolymers containing Adriamycin. Biomaterials, 10: 335-342, 1989.
20. Krinick, N L , Sun, Y., Joyner, D , Spikes, J D., Straight, R. C , and Kopeček, J. A polymeric drug delivery system for the simultaneous delivery of drugs activatable by enzymes and/or light J. Biomater Sci Polym. Ed., 5: 303-324, 1994
21. Rejmanová, P., Labsky, J , and Kopeček, J. Aminolysis of monomeric and polymeric p-nitrophenyl esters of methacryloylated amino acids. Makromol. Chem., 178, 2159-2168, 1977.
22. Veenhizen, R. B., Ruevekamp-Helmers, M. C , Heimerhorst, T J , Kenemans, P , Mooi, W J , Marijnissen, J. P., and Stewart, F. A. Intraperitoneal photodynamic therapy in the rat, comparison of toxicity profiles for Photofrin and MTHPC Int J Cancer, 19: 830-836, 1994
23. Jain, R. K. Delivery of molecular medicine to solid tumors. Science (Washington DC), 271 1079-1080, 1996.
24. Ringsdorf, H Structure and properties of pharmacologically active polymers. J. Polym Sci., Polym Symp., 51: 135-153, 1975.
25. Kopeček, J., and Duncan, R. Targetable polymeric prodrugs. J. Controlled Release, 6: 315-327, 1987
26. Duncan, R., Seymour, L W , O'Hare, K B., Flanagan, P. A., Wedge, S , Hume, I C., Ulbrich, K., Strohalm, J , Šubr, V., Speafico, F., Grandi, M , Ripamonti, M., Farao, M., and Suarato, A Preclinical evaluation of polymer-bound doxorubicin. J. Controlled Release, 19 331-346, 1992.
27. Duncan, R., Hume, I C., Kopečková, P., Ulbrich, K., Strohalm, J., and Kopeček, J. Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. 3. Evaluation of Adriamycin conjugates against mouse leukaemia L1210 in vivo J. Controlled Release, 10: 51-63, 1989.
28. Cassidy, J., Vasey, P., Kaye, S B., and Duncan, R A Phase I clinical trial of PK1; a novel drug targeting system in human cancers. In: Proceedings of the 1st International Symposium on Polymeric Therapeutics, January 10-12, 1996, p 21. London, United Kingdom: The School of Pharmacy, University of London, 1996.
29. Ozols, R F , Locker, G. Y , Doroshow, J. H., Grotzinger, K. R., Myers, C. E., Fisher, R. I , and Young, R. C. Chemotherapy of murine ovarian cancer: a rationale for i.p. therapy with Adriamycin. Cancer Treat. Rep., 63: 269-273, 1979.
30. Cassidy, J., Duncan, R., Morrison, G. J., Strohalm, J., Plocová, D , Kopeček, J., and Kaye, S. B. Activity of N-(2-hydroxypropyl)methacrylamide copolymers containing daunomycin against a rat tumour model. Biochem. Pharmacol., 38: 875-879, 1989
31. Seymour, L. W Passive tumor targeting of soluble macromolecules and drug conjugates. Crit. Rev. Ther. Drug Carrier Syst., 9: 135-187, 1992.
32. Trouet, A , and Jolles, G. Targeting of daunomycin by association with DNA or proteins: a review. Semin Oncol , 217: 248-252, 1984.
33. Duncan, R., Kopeckova, P., Strohalm, J., Hume, I C., Lloyd, J. B., and Kopeček, J Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers 2. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia. Br J. Cancer, 57; 147-156, 1988
34. Ornelyanenko, V., Kopečková, P., Gentry, C., and Kopeček, J. Performance of HPMA copolymer-drug conjugate antibody targeted to ovarian carcinoma cells. In: Proceedings of the 23rd International Symposium on Controlled Release of Bioactive Materials, Kyoto, Japan. July 7-10, 1996 Deerfield, Illinois: The Controlled Release Society, pp. 633-634
35. Dougherty, T Photosensitizers: therapy and detection of malignant tumors Photochem Photobiol., 45: 879-889, 1987.
36. Tochner Z, Mitchell, J. B., and Smith P. Photodynamic therapy of ascites tumors within the peritoneal cavity Br. J. Cancer, 53: 733-736, 1986.
37. Goff, B. A., Bamberg, M , and Hasan, T. Photoimmunotherapy of human ovarian carcinoma cells ex vivo. Cancer Res., 51 4762-4767, 1991.
38. Raab, G. N., Schneider, A F , Eierman, W. Gootschalk-Deponte, H., Baumgartner, R., and Beyer, W Response of human endometrium and ovarian carcinoma cells lines to photodynamic therapy Arch Gynecol. Obstet, 248: 13-20, 1990.
39. Kostenich, G. A , Zhuravkin, I N., and Zahvrid, E. A Experimental grounds for using chlorin e6 in the photodynamic therapy of malignant tumors. J Photochem. Photobiol. B. Biol , 22: 211-217, 1994
40. Roberts, W G., and Hasan T. Role of neovasculature and vascular permeability on the tumor retention of photodynamic agents. Cancer Res., 52: 924-930, 1992.
41. 6 on vessel constriction, vessel leakage, and tumor response. Cancer Res , 54: 5374-5379, 1994.
42. Zieve, P. D., Solomon, H. M., and Krevans, J. R The effect of hematoporphyrin and light on human platelets. I Morphologic, functional, and biochemical changes. J. Cell. Physiol., 67: 271-280, 1966.
43. Solomon, H. M , Zieve, P. D , and Krevans, J. R. The effect of hematoporphyrin and light on human platelets. II. Uptake of hematoporphyrin. J Cell. Physiol , 67: 281-284, 1966.
44. Henderson, B. W., Owezarenak, B., Sweeny, J., and Gessner, T. Effects of photodynamic treatment of platelets or endothelial cells in vitro on platelet aggregation Photochem. Photobiol., 56 513-521, 1992.
45. 6 - N-(2-hydroxypropyl)methacrylamide copolymer conjugate. J Photochem. Photobiol. A. Chem , 70: 163-170, 1993.
46. 6 conjugates and a preliminary study of their photodynamic effect on mouse splenocytes in vitro. Makromol Chem , 191: 839-856, 1990.
47. Maeda, H., Seymour, L W., and Miyamoto, Y. Conjugates of antitumor agents and polymers: advances of macromolecular therapeutics in vivo. Bioconjugate Chem., 3: 351-362, 1992.
48. Matsumura, Y., and Maeda, H. A new concept for macromolecular therapeutics in cancer chemotherapy, mechanisms of tumoritropic accumulation of proteins and the antitumor agent. Cancer Res., 6: 6387-6392, 1986
49. Omelyanenko, V., Kopečková, P., Gentry, C., Shiah, J G., and Kopeček, J. HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 1. Influcence of the method of synthesis on the binding affinity to OVCAR-3 ovarian carcinoma cells in vitro J Drug Targeting, 3: 357-373, 1996
50. Lanks, K. W , Gao, J P , and Sharma, T Pholodynamic enhancement of doxorubicin cytotoxicity. Cancer Chemother Pharmacol , 35 17-20, 1994