Bacterial cell envelopes (ghosts) but not S-layers activate human endothelial cells (HUVECs) through sCD14 and LBP mechanism

Vaccine

Volumn 18, Issue 5-6, 1999, Pages 440-448

  Fürst Ladani, Shayesteh ^a   Redl, Heinz ^a   Haslberger, Alexander ^b   Lubitz, Werner ^b   Messner, Paul ^c   Sleytr, Uwe B ^c   Schlag, Günther ^a  

^a LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

Author keywords

Bacterial ghosts; Cytokines; Endotoxicity; HUVEC; S layers

Indexed keywords

BINDING PROTEIN; CELL SURFACE PROTEIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERLEUKIN 6; MEMBRANE ANTIGEN;

ARTICLE; BACTERIAL MEMBRANE; CONTROLLED STUDY; ENDOTHELIUM CELL; ESCHERICHIA COLI; GEOBACILLUS STEAROTHERMOPHILUS; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY; PRIORITY JOURNAL; UMBILICAL VEIN;

ACUTE-PHASE PROTEINS; ANTIGENS, CD14; BACILLUS STEAROTHERMOPHILUS; CARRIER PROTEINS; CELLS, CULTURED; E-SELECTIN; ENDOTHELIUM, VASCULAR; ESCHERICHIA COLI; HUMANS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS;

EID: 0344132646     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(99)00241-8     Document Type: Article

References (26)

1. Witte A., Wanner G., Bläsi U., Halfmann G., Szostak M., Lubitz W. Endogenous transmembrane tunnel formation mediated by PhiX174 lysis protein. J. Bact. 172:1990;4109-4114.
2. Witte A., Wanner G., Lubitz W. Dynamics of PhiX174 protein E-mediated lysis of Escherichia coli. Arch. Microbiol. 157:1992;381-388.
3. Eko F.O., Hensel A., Bunka S., Lubitz W. Immunogenicity of Vibrio cholerae ghosts following intraperitoneal immunization of mice. Vaccine. 12:1994;1330-1334.
4. Hensel A., Van Leengoed L.A.G., Szostak M., Windt H., Weisenböck H., Stockhofe-zurwieden N., Katinger A., Stadler M., Ganter M., Bunka S., Pabst R., Lubitz W. Induction of protective immunity by aerosol or oral application of candidate vaccines in a dose-controlled pig aerosol infection model. J. Biotechnol. 44:1996;171-181.
5. Szostak M., Lubitz W. Recombinant bacterial ghosts as multivaccine vehicles. Chanock R.M. Vaccines 91: modern approaches to new vaccines including prevention of AIDS. 1991;409-414 Cold Spring Harbor Laboratory Press, New York.
6. Sleytr UB, Messner P, Pum D, Sára M, editors. Crystalline bacterial cell surface proteins. Austin, TX: R.G.Landes/Academic Press, 1996.
7. Sleytr U.B., Sára M. Bacterial and archeal S-layer proteins: structure-function relationships and their biotechnological applications. Trends Biotechnol. 15:1997;20-26.
8. Messner P., Unger F.M., Sleytr U.B. Vaccine development based on S-layer technology. Sleytr U.B., Messner P., Pum D., Sára M. Crystalline bacterial cell surface proteins. 1996;161-173 R.G. Landes Comp./Academic Press, Inc, Austin, TX.
9. Sleytr U.B., Bayley H., Sára M., Breitwieser A., Küpcü S., Mader C., Weigert S., Unger F.M., Messner P., Jahn-Schmid B., Schuster B., Pum D., Douglas K., Clark N.A., Moore J.T., Winningham T.A., Levy S., Frithsen I., Pankovc J., Beagle P., Gillis H.P., Choutov D.A., Martin K.P. Applications of S-layers FEMS. Microbiol. Rev. 20:1997;151-175.
10. Jahn-Schmid B., Messner P., Unger F.M., Sleytr U.B., Scheiner O., Kraft D. Towards selective elicitation of TH1 controlled vaccination responses. Vaccine Appl. Bact. Surf. Layer Proteins J. Biotechnol. 44:1996;225-231.
11. h0 phenotype in vitro by induction of IL-12. Int Immunol. 9:1997;1867-1874.
12. Schleimer R.P., Rutledge B.K. Cultured human vascular endothelial cells acquire adhesiveness for neutrophils after stimulation with interleukin 1, endotoxin and tumor-producing phorbol diesters. J. Immunol. 136:1986;649-654.
13. Bevilacqua M.P., Pober J.S., Mendrick D.L., Cotran R.S., Gimbrone M.A. Identification of an inducible endothelial-leukocyte adhesion molecule. Proc. Natl. Acad. Sci. USA. 84:1987;9238-9242.
14. Wright S.D., Ramos R.A., Tobias P.S., Ulevitch R.J., Mathison J.C. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science. 249:1990;1431-1433.
15. Heumann D., Gallay P., Barras C., Zaech P., Ulevitch R.J., Tobias P.S., Glauser M.P., Baumgartner J.D. Control of lipopolysaccharide (LPS) binding and LPS-induced tumor necrosis factor secretion in human peripheral blood monocytes. J. Immunol. 148:1991;3505-3512.
16. Dentener M.A., Bazil V., von Asmuth E.J.U., Ceska M., Buurmanm W.A. Involvement of CD14 in lipopolysaccharide induced tunor necrosis factor-α, interleukin-6 and interleukin-8 release by human monocytes and alveolar macrophages. J. Immunol. 150:1993;2885-2891.
17. Schumann R.R., Leong S.R., Flaggs G.W., et al. Structure and function of lipopolysaccharide binding protein. Science. 249:1990;1429-1431.
18. Froon A.H.M., Dentener M.A., Greve J.W.M., Ramsay G., Buurman W.A. Lipopolysaccharide toxicity-regulating proteins in bacteremia. J. Infect. Dis. 171:1995;1250-1257.
19. Grunwald U., Krüger C., Westmann J., Lukowsky A., Ehlers M., Schütt C. An enzyme-linked immunosorbent assay for the qualification of solublized CD14 in biological fluids. J. Immunol. 155:1992;225-232.
20. Wright S.D., Tobias P.S., Ulevitch R.J., Ramos R.A. Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J. Exp. Med. 170:1989;1231-1241.
21. Pugin J., Schürer-Maly C.-C., Leturcq D., Moriarty A., Ulevitch R.J., Tobias P.S. Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc. Natl. Acad. Sci. USA. 90:1993;2744-2748.
22. Messner P., Sleytr U.B. Separation and purification of S-layers from gram-positive and gram-negative bacteria. Hancock I., Poxton I. Bacterial cell surface techniques. 1988;97-104 J. Wiley and Sons, Chichester.
23. Jahn-Schmid B., Graninger M., Glozik M., Küpcü S., Ebner S., Unger F.M., Sleytr U.B., Messner P. Immunoreactivity of allergen (Bet v 1) conjugated to crystalline bacterial cell surface layers (S-layers). Immunotechnology. 2:1996;103-113.
24. Haslberger A.G., Mader H.J., Schmalnauer M., Kohl G., Messner P., Sleytr U.B., Wanner G., Fürst-Ladani S., Lubitz W. Bacterial cell envelopes (ghosts) and LPS but not bacterial S-layers induce synthesis of immune-mediators in mouse macrophages involving CD14. J Endotoxin Res. 4:1997;431-441.
25. Von Asmuth E.J.U., Dentener M.A., Bazil V.B., Bouma M.G., Leeuwenberg F.M., Buurmann W.A. AntiCD14 antibodies reduce responses of cultured human endothelial cells to endotoxin. Immunology. 80:1993;78-83.
26. Ishii Y., Shuyi W., Kitamura S. Soluble CD14 in serum mediates LPS-induced increase in permeability of bovine pulmonary arterial endothelial cell monolayers in vitro. Life Sci. 56:(25):1995;2263-2272.