The effect of the base on the kinetics of action of the capsaicinoid nonivamide: Evaluation with a hyperemic test

Skin Pharmacology and Applied Skin Physiology

Volumn 12, Issue 5, 1999, Pages 289-298

  Stucker M ^a,c   Reuther, T ^a   Hoffmann, K ^a   Aicher, B ^b   Altmeyer, P ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c ST JOSEF HOSPITAL   (Germany)

Author keywords

Axon reflex; Capsaicin; Finalgon; Laser Doppler perfusion imaging; Nicoboxil; Nonivamide

Indexed keywords

FINALGON; NICOBOXIL; NONIVAMIDE; PERIPHERAL VASODILATING AGENT; WATER OIL CREAM;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; HUMAN; HUMAN EXPERIMENT; LASER DOPPLER FLOWMETRY; PRIORITY JOURNAL;

ADOLESCENT; ADULT; CAPSAICIN; EMULSIONS; ERYTHEMA; HUMANS; HYPEREMIA; LASER-DOPPLER FLOWMETRY; MIDDLE AGED; NICOTINIC ACIDS; OINTMENT BASES; REGIONAL BLOOD FLOW; SKIN;

EID: 0344131362     PISSN: 14222868     EISSN: None     Source Type: Journal    
DOI: 10.1159/000066255     Document Type: Article

References (23)

1. Fusco BM, Giacovazzo M: Peppers and pain - the promise of capsaicin. Drugs 1977;53:909-914.
2. Brain SD, Tippins JR, Morris HR, Maclntyre I, Williams TJ: The potent vasodilator activity of calcitonin gene-related peptide in human skin. J Invest Dermatol 1986;87: 533-536.
3. Brain SD, Williams TJ, Tippins JR, Morris HR, MacIntyre I: Calcitonin gene-related peptide (CGRP) is a potent vasodilator. Nature 1985; 313:54-56.
4. Jessell TM, Iversen LL, Cuello AC: Capsaicin-induced depletion of substance P from primary sensory neurons. Brain Res 1978;152:183-188.
5. Jancso G, Kiraly E, Jancso-Gabor A: Pharmacologically induced selective degeneration of chemosensitive primary sensory neurons. Nature 1977; 270:741-743.
6. Biro T, Acs G, Acs P, Modarres S, Blumberg PM: Recent advances in understanding of vanilloid receptors: A therapeutic target for treatment of pain and inflammation in skin. J Invest Dermatol Symp Proc 1997;2:56-60.
7. Ellison N, Loprinzi CL, Kugler J, Hatfield AK, Miser A, Sloan JA, Wender DB, Rowland KM, Molina R, Cascino TL, Vukov AM, Dhaliwal HS, Ghosh C: Phase III placebo-controlled trial of capsaicin O/W emulsion in the management of surgical neuropathic pain in cancer patients. J Clin Oncol 1997;15:2974-2980.
8. Altmeyer P: Modification of experimental UV-erythema by external steroids - a reflex-photometric study. Arch Dermatol Res 1977; 258:203-209.
9. Noon JP, Evans CE, Haynes WG, Webb DJ, Walker BR: A comparison of techniques to assess skin blanching following the topical application of glucocorticoids. Br J Dermatol 1996;134:837-842.
10. Skofitsch G, Donnerer J, Lembeck F: Comparison of nonivamide and capsaicin with regard to their pharmacokinetics and effects on sensory neurons. Arzneimittelforschung 1984;43:154-156.
11. Stoughton R, Clendenning WE, Kruse D: Percutaneous absorption of nicotinic acid and derivates. J Invest Dermatol 1960;35:337-341.
12. Fountain RB, Baker BS, Hadgraft JW, Sarkany I: The rate of absorption and duration of action of four different solutions of methyl nicotinate. Br J Dermatol 1969;81:202-206.
13. Wilkin JK, Fortner G, Reinhardt LA: Prostaglandins and nicotinate-provoked increase on cutaneous blood flow. Clin Pharmacol Ther 1983;38:273-277.
14. Guy RH, Tur E, Bugatto B: Pharmacodynamic measurements of methyl nicotinate percutaneous absorption. Pharm Res 1984;2:76-81.
15. Aicher B, Stücker M, Altmeyer P: Arzneistoffe für die Haut-Reiz-Therapie. Neue Methoden zur Objektivierung der pharmakologischen Wirkung von Nonivamid, Nicoboxil und ihrer Kombination. Apotheker J 1996;18:44-50.
16. Wardell K, Jakobsson A, Nilsson GE: Laser Doppler perfusion imaging by dynamic light scattering. IEEE Trans Biomed Eng 1993;40: 309-316.
17. Wardell K, Naver HK, Nilsson GE, Walling BG: The cutaneous vascular axon reflex in humans characterised by laser Doppler perfusion imaging. J Physiol 1993;460:185-193.
18. Stücker M, Auer T, Hoffmann K, Altmeyer P: Two dimensional blood flow determinations in allergic reactions using laser Doppler scanning. Contact Dermatitis 1995;33:58-64.
19. 1-blockers by non-invasive measurement techniques. Dermatology 1994;189: 146-151.
20. Stücker M, Heese A, Hoffmann K, Röchling A, Altmeyer P: Precision of laser Doppler scanning in clinical use. Clin Exp Dermatol 1995;20: 371-376.
21. Schalla W, Schaefer H: Pharmacokinetics and topical applications of drugs; in Fitzpatrick TB, Eisen AZ, Wolff K, Freedeberg IM, Austen KF: Dermatology in General Medicine, ed 3. New York, McGraw-Hill, 1987, pp 2525-2532.
22. Kenneth AA, Mendenhall PV: The pharmacology of topical therapy; in Fitzpatrick TB, Eisen AZ, Wolff K, Freedeberg IM, Austen KF: Dermatology in General Medicine, ed 3. New York, McGraw-Hill, 1987, pp 2532-2549.
23. Plötze B: Die pharmakologische Wirksamkeit der neuen Hauthyperämika Nonylsäurevanillylamid und Nikotinsäure-β-butoxyaethylester und ihre klinische Anwendung. Arzneimittelforschung 1951;1:305-309.