Delivery of liposomes in dry powder form: Aerodynamic dispersion properties

European Journal of Pharmaceutical Sciences

Volumn 20, Issue 4-5, 2003, Pages 459-467

  Desai, Tejas R ^a   Hancock, Robert E W ^b   Finlay, Warren H ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cationic peptide; Ciprofloxacin; Liposome aerosol; Liposomes; Powder aerosol; Salbutamol sulfate

Indexed keywords

AEROSOLS; DISPERSIONS; ENCAPSULATION; PHOSPHOLIPIDS; TURBULENCE;

DEAGGLOMERATION;

DRUG PRODUCTS;

ANTIBIOTIC AGENT; BRONCHODILATING AGENT; CIPROFLOXACIN; CM 3; LIPOSOME; PHOSPHOLIPID; SALBUTAMOL; UNCLASSIFIED DRUG;

AEROSOL; ARTICLE; DISPERSION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRY POWDER; ENCAPSULATION; FLOW RATE; PARTICLE SIZE; PHYSICAL CHEMISTRY; POWDER; PRIORITY JOURNAL;

EID: 0344083495     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2003.09.008     Document Type: Article

References (21)

1. Alpar O.H., Bamford J.B., Walters V. In vitro incorporation of release of hydroxycobalamin by liposomes. Int. J. Pharm. 7:1981;349-351.
2. Crowder T.M., Louey M.D., Sethuraman V.V., Smyth H.D.C., Hickey A.J. An odyssey in inhaler formulation and design. Pharm. Technol. 25(7):2001;99-113.
3. Desai T.R., Wong J.P., Hancock R.E.W., Finlay W.H. A novel approach to the pulmonary delivery of liposomes in dry powder form to eliminate the deleterious effects of milling. J. Pharm. Sci. 91:2002;482-491.
4. Finlay, W.H., 2001. The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction. Academic Press, UK.
5. Finlay W.H., Wong J.P. Regional lung deposition of nebulized liposome encapsulated ciprofloxacin. Int. J. Pharm. 167:1998;121-127.
6. Gilbert B.E., Wyde P.R., Wilson S.Z., Robins R.K. Aerosol and intraperitoneal administration of ribavarin and ribavarin triacetate: pharamcokinetics and protection of mice against intracerebral infection with influenza A/WSN virus. Antimicrob. Agents Chemother. 35(7):1991;1448-1453.
7. Gregoriadis, G. (Ed.), 1988. Liposomes as Drug Carriers. Wiley, London.
8. Ho, J., 1995. Generation and analysis of liposome aerosols. In: Shek, P.N. (Ed.), Liposomes in Biomedical Applications. Harwood Academic Publishers, GmBH, pp. 199-208.
9. Johnson S.M. The effect of charge and cholesterol on the size and thickness of phospholipid vesicles. Biochim. Biophys. Acta. 307:1973;27-41.
10. Joshi M., Misra A. Dry powder inhalation of liposomal ketotifen fumarate: formulation and characterization. Int. J. Pharm. 223:2001;15-27.
11. Lange C.F., Hancock R.E.W., Samuel J., Finlay W.H. In vitro delivery and regional airway surface liquid concentration of a liposomal cationic peptide. J. Pharm. Sci. 90:2001;1647-1657.
12. Mobley W.C. The effect of jet-milling on lyophilized liposomes. Pharm. Res. 15:1998;149-152.
13. Newman, S.P., Pavia, D., 1985. In: Moren, F., Newhouse, M.T., Dolovich, M.B. (Eds.), Aerosols in Medicines. Elsevier, New York, p. 193.
14. Nichols S.C., Brown D.R., Smurthwaite M. New concepts for the variable flow rate Andersen cascade impactor and calibration data. J. Aerosol Med. 11(Supplement 1):1998;S133-S138.
15. Niven R.W., Carvajal M.A., Schreier H. Nebulization of liposomes. III. The effects of operating conditions and local environment. Pharm. Res. 9:1992;515-520.
16. Parthasarathy R., Gilbert B., Mehta K. Aerosol delivery of liposomal all-trans retinoic acid to the lungs. Cancer Chemother. Pharmacol. 43:1999;277-283.
17. Schreier H., Mobley W.C., Concessio N., Hickey A.J., Niven R.W. Formulation and in vitro performance of liposome powder aerosol. STP Pharm. Sci. 4:1994;38-44.
18. Scott M.G., Yan H., Hancock R.E.W. Biological properties of structurally related α-helical cationic antimicrobial peptide. Infect. Immun. 67:1999;2005-2009.
19. Voss, A.P., 2001. Deaggregation of dry powder pharmaceutical aerosols. Master of Science Dissertation, University of Alberta, 2001.
20. Voss A.P., Finlay W.H. Deagglomeration of dry powder pharmaceutical aerosols. Int. J. Pharm. 248:2002;39-50.
21. Weinstein J.N., Leserman L.D. Liposomes as drug carriers in cancer chemotherapy. Pharmacol. Ther. 24:1984;207-233.