Functional interactions between herpesvirus oncoprotein MEQ and cell cycle regulator CDK2

Journal of Virology

Volumn 73, Issue 5, 1999, Pages 4208-4219

  Juinn Lin, Liu ^a,b   Ying, Ye ^c   Qian, Zheng ^a   Qian, Yongyi ^a   Templeton, Dennis J ^a   Lucy F, Lee ^b   Kung, Hsing Jien ^a,d  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b U S DEPARTMENT OF AGRICULTURE   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; CYCLIN DEPENDENT KINASE; ONCOPROTEIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; AVIAN LYMPHOMATOSIS HERPETOVIRUS; CELL CYCLE; CELLULAR DISTRIBUTION; DNA BINDING; HERPES VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; VIRUS CARCINOGENESIS; VIRUS CELL TRANSFORMATION;

EID: 0344076208     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.5.4208-4219.1999     Document Type: Article

References (80)

1. 33cdk2. J. Virol. 67:6551-6557.
2. Arroyo, M., S. Bagchi, and P. Raychaudhuri. 1993. Association of the human papillomavirus type 16 E7 protein with the S-phase-specific E2F-cyclin A complex. Mol. Cell. Biol. 13:6537-6546.
3. Baines, J. D., R. J. Jacob, L. Simmerman, and B. Roizman. 1995. The herpesvirus 1 UL11 proteins are associated with cytoplasmic and nuclear membranes and with nuclear bodies of infected cells. J. Virol. 69:825-833.
4. Bex, F., A. McDowall, A. Burny, and R. Gaynor. 1997. The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-κB proteins. J. Virol. 71:3484-3497.
5. Bohmann, K., J. Ferreira, N. Santama, K. Weis, and A. I. Lamond. 1995. Molecular analysis of the coiled body. J. Cell Sci. Suppl. 19:107-113.
6. 1 checkpoint function. J. Virol. 71:5861-5870.
7. Boulikas, T. 1995. Phosphorylation of transcription factors and control of cell cycle. Crit. Rev. Eukaryotic Gene Expression 5:1-77.
8. Bradley, G., G. Lancz, A. Tanaka, and M. Nonoyama. 1989. Loss of Marek's disease virus tumorigenicity is associated with truncation of RNAs transcribed within BamHI-H. J. Virol. 63:4129-4135.
9. 1 phases of the cell cycle. Cell Growth Differ. 7:1283-1290.
10. Brunovskis, P., Z. Qian, D. Li, L. F. Lee, and H.-J. Kung. 1996. Functional analysis of the MDV basic-leucine zipper product, MEQ, p. 265-270. In R. F. Silva, H. H. Cheng, P. M. Coussens, L. F. Lee, and L. F. Velicer (ed.), Current research on Marek's disease. American Association of Avian Pathologists, Kennett Square, Pa.
11. Calnek, B. W. 1985. Marek's disease-a model for herpesvirus oncology. Crit. Rev. Microbiol. 12:293-320.
12. Carroll, R. B., and E. G. Gurney. 1982. Time-dependent maturation of the simian virus 40 large T antigen-p53 complex studied by using monoclonal antibodies. J. Virol. 44:565-573.
13. Cujec, T. P., H. Okamoto, K. Fujinaga, J. Meyer, H. Chamberlin, D. O. Morgan, and B. M. Peterlin. 1997. The HIV transactivator TAT binds to the CDK-activating kinase and activities the phosphorylation of the carboxy-terminal domain of RNA polymerase II. Genes Dev. 11:2645-2657.
14. DeCaprio, J. A., J. W. Ludlow, J. Figge, J. Y. Shew, C. M. Huang, W. H. Lee, E. Marsilio, E. Paucha, and D. M. Livingston. 1988. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54:275-283.
15. de Jong, L., M. A. Grande, K. A. Mattern, W. Schul, and R. van Driel. 1996. Nuclear domains involved in RNA synthesis, RNA processing, and replication. Crit. Rev. Eukaryotic Gene Expression 6:215-246.
16. Dyson, N., P. M. Howley, K. Munger, and E. Harlow. 1989. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product Science 243:934-937.
17. Fischer, U., J. Huber, W. C. Boelens, I. W. Mattaj, and R. Luhrmann. 1995. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82:475-483.
18. Funk, J. O., S. Waga, J. B. Harry, E. Espling, B. Stillman, and D. A. Galloway. 1997. Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein. Genes Dev. 11:2090-2100.
19. Gall, J. G., A. Tsvetkov, Z. Wu, and C. Murphy. 1995. Is the sphere organelle/coiled body a universal nuclear component? Dev. Genet. 1:25-35.
20. Gold, M. O., J. P. Tassan, E. A. Nigg, A. P. Rice, and C. H. Herrmann. 1996. Viral transactivators E1A and VP16 interact with a large complex that is associated with CTD kinase activity and contains CDK8. Nucleic Acids Res. 24:3771-3777.
21. Hagemeier, C., R. Caswell, G. Hayhurst, J. Sinclair, and T. Kouzarides. 1994. Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein. EMBO J. 13:2897-2903.
22. Hermanns, J., A. Schulze, P. Jansen-Durr, J. A. Klein-Schmidt, R. Schmidt, and H. zur Hausen. 1997. Infection of primary cells by adeno-associated virus type 2 results in a modulation of cell cycle-regulatory proteins. J. Virol. 71:6020-6027.
23. Hickman, E. S., S. Bates, and K. H. Vousden. 1997. Perturbation of the p53 response by human papillomavirus type 16 E7. J. Virol. 71:3710-3718.
24. Horton, L. E., and D. J. Templeton. 1997. The cyclin box and C-terminus of cyclins A and E specify CDK activation and substrate specificity. Oncogene 14:491-498.
25. Hunter, T., and M. Karin. 1992. The regulation of transcription by phosphorylation. Cell 70:375-387.
26. Ishov, A. M., and G. G. Maul. 1996. The periphery of nuclear domain 10 (ND10) as site of DNA virus deposition. J. Cell Biol. 134:815-826.
27. Jans, P. A., M. Ackerman, J. R. Bischoff, D. H. Beach, and S. Peter. 1991. p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteins. J. Cell Biol. 115:1203-1212.
28. Jans, D. A., T. Moll, K. Nasmyth, and P. Jans. 1995. Cyclin-dependent kinase site-regulated signal-dependent nuclear localization of the SW15 yeast transcription factor in mammalian cells. J. Biol. Chem. 270:17064-17067.
29. Jans, D. A., and S. Hubner. 1996. Regulation of protein transport to the nucleus: central role of phosphorylation. Physiol. Rev. 76:651-685.
30. Jansen-Durr, P. 1996. How viral oncogenes make the cell cycle. Trends Genet. 12:270-275.
31. Jimenez-Garcia, L. F., S. Green, M. Mathews, and D. L. Spector. 1993. Organization of the double-stranded RNA-activated protein kinase DAI and virus-associated VA RNA1 in adenovirus-2-infected HeLa cells. J. Cell Sci. 106:11-22.
32. Jones, D., L. Lee, J.-L. Liu, H.-J. Kung, and J. K. Tillotson. 1992. Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors. Proc. Natl. Acad. Sci. USA 89:4042-4046.
33. Jordan, P., C. Cunha, and M. Carmo-Fonseca. 1997. The cdk7-cyclin H-MAT1 complex associated with TFIIH is localized in coiled bodies. Mol. Biol. Cell 8:1207-1217.
34. Jung, J. U., M. Stager, and R. C. Desrosiers. 1994. Virus-encoded cyclin. Mol. Cell. Biol. 14:7235-7244.
35. Kato, S., and K. Hirai. 1985. Marek's disease virus. Adv. Virus Res. 30:225-277.
36. Kawaguchi, Y., C. Van Sant, and B. Roizman. 1997. Herpes simplex virus 1 alpha regulatory protein ICP0 interacts with and stabilizes the cell cycle regulator cyclin D3. J. Virol. 71:7328-7336.
37. Knudsen, E. S., C. Buckmaster, T. T. Chen, J. R. Feramisco, and J. Y. Wang. 1998. Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression. Genes Dev. 12:2278-2292.
38. Lee, L. Unpublished results.
39. Li, M., H. Lee, D. W. Yoon, J. C. Albrecht, B. Fleckenstein, F. Neipel, and J. U. Jung. 1997. Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin. J. Virol. 71:1984-1991.
40. Liu, J.-L., L. F. Lee, Y. Ye, Z. Qian, and H.-J. Kung. 1997. Nucleolar and nuclear localization properties of a herpesvirus bZIP oncoprotein, MEQ. J. Virol. 71:3188-3196.
41. Liu, J.-L., Y. Ye, L. F. Lee, and H.-J. Kung. 1998. Transforming potential of the herpesviral oncoprotein MEQ: morphological transformation, serum-independent growth, and inhibition of apoptosis. J. Virol, 72:388-395.
42. Low, K. G., L. F. Dorner, D. B. Fernando, J. Grossman, K. T. Jeang, and M. J. Comb. 1997. Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a. J. Virol. 71:1956-1962.
43. Mal, A., R. Y. Poon, P. H. Nowe, H. Toyoshima, T. Hunter, and M. L. Harter. 1996. Inactivation of p27Kip1 by the viral E1A oncoprotein in TGF betatreated cells. Nature 380:262-265.
44. Matera, A. G. 1998. Of coiled bodies, gems and salmon. J. Cell. Biochem. 70:181-192.
45. McIntyre, M. C., M. N. Ruesch, and L. A. Laimin. 1996. Human papillomavirus E7 oncoproteins bind a single form of cyclin E in a complex with cdk2 and p107. Virology 215:73-82.
46. Meyer, B. E., and M. H. Malim. 1994. The HIV Rev trans-activator shuttles between the nucleus and the cytoplasm. Genes Dev. 8:1538-1547.
47. Michael, W. M., M. Chol, and G. Dreyfuss. 1995. A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway. Cell 83:415-422.
48. Moll, T., G. Tebb, U. Surana, H. Kobitsch, and K. Nasymth. 1991. The role of phosphorylation and the CDC28 kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. Cell 64:743-758.
49. Muralidhar, S., J. Doniger, E. Mendelson, J. C. Araujo, F. Kashanchi, N. Azumi, J. N. Brady, and L. J. Rosenthal. 1996. Human cytomegalovirus mtrII oncoprotein binds to p53 and down-regulates p53-activated transcription. J. Virol. 70:8691-8700.
50. Nekhai, S., R. R. Shukla, and A. Kumar. 1997. A human primary T-lympho-cyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity. J. Virol. 71:7436-7441.
51. Neuveut, C., K. G. Low, F. Maldarelli, I. Schmitt, F. Majone, R. Grassmann, and K.-T. Jeang. 1998. Human T-cell leukemia virus 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb. Mol. Cell. Biol. 18:3620-3632.
52. O'Neil, R. E., J. Talon, and P. Palese. 1998. The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins. EMBO J. 17:288-296.
53. O'Neill, E. M., A. Kaffman, E. R. Jolly, and E. K. O'Shea. 1996. Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex. Science 271:209-212.
54. Palmeri, D., and M. H. Malim. 1996. The human T-cell leukemia virus type 1 posttranscriptional trans-activator Rex contains a nuclear export signal. J. Virol. 70:6442-6445.
55. Parker, G. A., T. Crook, M. Bain, E. A. Sara, P. J. Farrell, and M. J. Allday. 1996. Epstein-Barr virus nuclear antigen (EBNA) 3C is an immortalizing oncoprotein with similar properties to adenovirus E1A and papillomavirus E7. Oncogene 13:2541-2549.
56. Parker, S. F., N. D. Perkins, S. D. Gitlin, and G. J. Nabel. 1996. A cooperative interaction of human T-cell leukemia virus type 1 Tax with the p21 cyclin-dependent kinase inhibitor activates the human immunodeficiency virus type 1 enhancer. J. Virol. 70:5731-5734.
57. Poma, E. E., T. F. Kowalik, L. Zhu, J. H. Sinclair, and E. S. Huang. 1996. The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter. J. Virol. 70:7867-7877.
58. Powell, P. C. 1985. Marek's disease virus in the chicken. Adv. Viral Oncol. 5:103-127.
59. Qian, Z., P. Brunovskis, F. Rauscher III, L. Lee, and H.-J. Kung. 1995. Transactivation activity of Meq, a Marek's disease herpesvirus bZIP protein persistently expressed in latently infected transformed T cells. J. Virol. 69: 4037-4044.
60. Qian, Z., P. Brunovskis, L. F. Lee, P. K. Vogt, and H.-J. Kung. 1996. Novel DNA binding specificities of a putative herpesvirus bZIP oncoprotein. J. Virol. 70:7161-7170.
61. Sandri-Gordin, R. M. 1998. ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motif. Genes Dev. 12:868-879.
62. Schat, K. A., A. Buckmaster, and L. J. Ross. 1989. Partial transcription map of Marek's disease herpesvirus in lytically infected cells and lymphoblastoid cell lines. Int. J. Cancer 44:101-109.
63. Schwab, M. S., and C. Dreyer. 1997. Protein phosphorylation sites regulate the function of the bipartite NLS of nucleolin. Eur. J. Cell Biol. 73:287-297.
64. Sugaya, K., N. Bradley, M. Nonoyama, and A. Tanaka. 1990. Latent transcripts of Marekís disease virus are clustered in the short and long repeat regions. J. Virol. 64:5773-5782.
65. Suzuki, T., S. Kitao, H. Matsushime, and M. Yoshida. 1996. HTLV-1 Tax protein interacts with cyclin-depcndent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4. EMBO J. 15:1607-1614.
66. Szekely, L., K. Pokrovskaja, W. Q. Jiang, H. de The, N. Ringertz, and G. Klein. 1996. The Epstein-Barr virus-encoded nuclear antigen EBNA-5 accumulates in PML-containing bodies. J. Virol. 70:2562-2568.
67. Tassan, J.-P., S. J. Schultz, J. Bartek, and E. A. Nigg. 1994. Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase). J. Cell Biol. 127:467-478.
68. Tillotson, J. K., H.-J. Kung, and L. F. Lee. 1988. Accumulation of viral transcripts coding for a DNA binding protein in Marek's disease tumor cells, p. 128-134. In The 3rd International Symposium on Marek's Disease. Japanese Association on Marek's Disease, Osaka, Japan.
69. Trinczek, B., M. Robert-Nicoud, and G. Schwoch. 1993. In situ localization of cAMP-dependent protein kinases in nuclear and chromosomal structures: relation to transcriptional activity. Eur. J. Cell Biol. 60:196-202.
70. Vousden, K. H. 1995. Regulation of the cell cycle by viral oncoproteins. Semin. Cancer Biol. 6:109-116.
71. Watanabe, G., A. Howe, R. J. Lee, C. Albanese, I. W. Shu, A. N. Karnezis, L. Zon, J. Kyriakis, K. Rundell, and R. G. Pestell. 1996. Induction of cyclin D1 by simian virus 40 small tumor antigen. Proc. Natl. Acad. Sci. USA 93:12861-12866.
72. Wei, P., M. E. Garber, S. M. Fang, W. H. Fischer, and K. A. Jones. 1998. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell 92:451-462.
73. Wen, W., J. L. Meinkoth, R. Y. Tsien, and S. S. Taylor. 1995. Identification of a signal for rapid export of proteins from the nucleus. Cell 82:463-473.
74. Werness, B. A., A. J. Levine, and P. M. Howley. 1990. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248:76-79.
75. Whyte, P., N. M. Williamson, and E. Harlow. 1989. Cellular targets for transformation by the adenovirus E1A proteins. Cell 56:67-75.
76. Xie, Q., A. S. Anderson, and R. W. Morgan. 1996. Marek's disease virus (MDV) ICP4, pp38, and meq genes are involved in the maintenance of transformation of MDCC-MSB1 MDV-transformed lymphoblastoid cells. J. Virol. 70:1125-1131.
77. Yan, M., T. Dai, J. C. Deak, J. M. Kyriakis, L. I. Zon, J. R. Woodgett, and D. J. Templeton. 1994. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature 372:798-800.
78. Yasuda, H., M. Kamijo, and Y. Ohba. 1993. The characterization of cdc2 kinase and CDK2. Yakugaku Zasshi 113:829-846.
79. Zantema, A., P. I. Schrier, A. Davis-Olivier, T. van Laar, R. T. Vaessen, and A. J. van der Eb. 1985. Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells. Mol. Cell. Biol. 5:3084-3091.
80. Zerfass-Thome, K., W. Zwerschke, B. Mannhardt, R. Tindle, J. W. Botz, and P. Jansen-Durr. 1996. Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein. Oncogene 13:2323-2330.