Effects of magnesium sulfate on neuron apoptosis and expression of caspase-3, bax and bcl-2 after cerebral ischemia-reperfusion injury

Chinese Medical Journal

Volumn 116, Issue 10, 2003, Pages 1532-1534

  Zhuo, Haiyan ^a   Ma, Yuefeng ^a   Zhou, Yifeng ^a   Liu, Ziming ^a   Wang, Kai ^a   Chen, Gang ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptosis; Bax; Bcl 2; Caspase 3; Ischemia reperfusion injury; Magnesium sulfate

Indexed keywords

CASPASE 3; MAGNESIUM SULFATE; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG MECHANISM; EXPERIMENTAL SURGERY; GERBIL; IMMUNOHISTOCHEMISTRY; NERVE CELL NECROSIS; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; REPERFUSION INJURY; STATISTICAL SIGNIFICANCE;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASES; CEREBROVASCULAR DISORDERS; GERBILLINAE; MAGNESIUM SULFATE; NEURONS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RANDOM ALLOCATION; REPERFUSION INJURY;

EID: 0344034633     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 1994;330:613-622.
2. Lyden P, Wahlgren NG. Mechanisms of action of neuroprotectants in Stroke. J Stroke Cerebrovascular Dis 2000;9:9-14.
3. Davis JN, Antonawich FJ. The role of apoptotic proteins in ischemic hippocampal damage. Ann NY Acad Sci 1997;835: 309-320.
4. Gross A, McDonnel JM, Korsmeyer SJ. Bcl-2 family members and the mitochondria in apoptosis. Genes Dev 1999;13:1899-1911.
5. Zhang S, Wang W. Altered expression of bcl-2 mRNA and Bax in hippocampus with focal cerebral ischemia model in rats. Chin Med J 1999;7:608-611.
6. Deng Y, Lin C, Zheng J, et al. Overexpression of Bcl-2 partly inhibits apoptosis of human cervical cancer SiHa cells induced by arsenic trioxide. Chin Med J 2000;1:84-88.
7. Knudson CM, Korsmeyer SJ. Bel-2 and Bax function independently to regulate cell death. Nat Genet 1997; 16: 358-363.
8. Nicholson DW, Thornberry NA. Caspases: killer proteases. TIBS 1997;22:299-306.
9. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 1998;281:1312-1316.
10. Robertson GS, Crocker SJ, Nicholson DW, et al. Neuroprotection by the inhibition of apoptosis. Brain Pathol 2000;10:283-292.
11. Cohen GM. Caspases: the executioners of apoptosis. Biochem J 1997;326:1-16.