Inhibitory effects of chlorophyllin, hemin and tetrakis(4-benzoic acid)porphyrin on oxidative DNA damage and mouse skin inflammation induced by 12-O-tetradecanoylphorbol-13-acetate as a possible anti-tumor promoting mechanism

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 542, Issue 1-2, 2003, Pages 89-97

  Park, Kwang Kyun ^a,b   Park, Jae Hee ^a,b   Jung, Youn Joo ^a   Chung, Won Yoon ^a  

^a Yonsei University College of Dentistry   (South Korea)

^b Yonsei University   (South Korea)

Author keywords

Anti tumor promoting activity; Antioxidative properties; Chlorophyllin; Hemin; TBAP

Indexed keywords

(4 BENZOIC ACID)PORPHYRIN; 4 O METHYLPHORBOL 13 ACETATE 12 MYRISTATE; 8 HYDROXYDEOXYGUANOSINE; CHLOROPHYLL; COPPER ION; HEMIN; HYDROGEN PEROXIDE; HYDROXYL RADICAL; MYELOPEROXIDASE; ORNITHINE DECARBOXYLASE; PORPHYRIN DERIVATIVE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TERT BUTYL HYDROPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN HL 60; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA STRAND; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FENTON REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; THYMUS;

SALMONELLA TYPHIMURIUM;

EID: 0344033666     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2003.09.001     Document Type: Article

References (36)

1. Trush M.A., Kensler T.W. An overview of the relationship between oxidative stress and chemical carcinogenesis. Free Radic. Biol. Med. 10:1991;201-209.
2. Athar M. Oxidative stress and experimental carcinogenesis. Indian J. Exp. Biol. 40:2002;656-667.
3. Cerruti P.A. Mechanisms of action of oxidant carcinogens. Cancer Detect. Prev. 14:1989;281-284.
4. Hayatsu H., Arimoto S., Negishi T. Dietary inhibitors of mutagenesis and carcinogenesis. Mutat. Res. 202:1988;429-446.
5. Odin A.P. Antimutagenicity of the porphyrins and non-enzyme porphyrin-containing proteins. Mutat. Res. 387:1997;55-68.
6. Dashwood R.H. Chlorophylls as anticarcinogens. Int. J. Oncol. 10:1997;721-727. (review).
7. Hayatsu H., Sugiyama C., Arimoto-Kobayashi S., Negishi T. Porphyrins as possible preventers of heterocyclic amine carcinogenesis. Cancer Lett. 143:1999;185-187.
8. Egner P.A., Wang J.-B., Zhu Y.-R., Zhang B.-C., Wu Y., Zhang Q.-N., Qian G.-S., Kuang S.-Y., Gange S.J., Jacobson L.P., Helzlsouer K.J., Bailey G.S., Groopman J.D., Kensler T.W. Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer. Proc. Natl. Acad. Sci. U.S.A. 98:2001;14601-14606.
9. Chung W.-Y., Lee J.-M., Park M.-Y., Yook J.-I., Kim J., Chung A.-S., Surh Y.-J., Park K.-K. Inhibitory effects of chlorophyllin on 7,12-dimethylbenz[a]anthracene-induced bacterial mutagenesis and mouse skin carcinogenesis. Cancer Lett. 145:1999;57-64.
10. Chung W.-Y., Lee J.-M., Lee W.-Y., Surh Y.-J., Park K.-K. Protective effects of hemin and tetrakis(4-benzoic acid)porphyrin on bacterial mutagenesis and mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene. Mutat. Res. 472:2000;139-145.
11. Sato M., Fujimoto I., Sakai T., Aimoto T., Kimura R., Murata T. Effect of sodium copper chlorophyllin on lipid peroxidation. IX. On the antioxidative components in commercial preparations of sodium copper chlorophyllin. Chem. Pharm. Bull. 34:1986;2428-2434.
12. Imai K., Aimoto T., Sato M., Kimura R. Antioxidative effect of several porphyrins on lipid peroxidation in rat liver homogenates. Chem. Pharm. Bull. 38:1990;258-260.
13. Chun K.-S., Sohn Y., Kim H.-S., Kim O.-H., Park K.-K., Lee J.-M., Lee J., Lee J.-Y., Moon A., Lee S.-S., Surh Y.-J. Anti-tumor promoting potential of naturally occurring diarylheptanoids structurally related to curcumin. Mutat. Res. 428:1999;49-57.
14. Maron D.M., Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113:1983;173-215.
15. Lewis J.G., Stewart W., Adams D.O. Role of oxygen radicals in induction of DNA damage by metabolite of benzene. Cancer Res. 48:1988;4762-4765.
16. Ahsan H., Parveen N., Khan N.U., Hadi S.M. Pro-oxidant, anti-oxidant and cleavage activities on DNA of curcumin and its derivatives demethoxycurcumin and bisdemethoxycurcumin. Chem.-Biol. Interactions. 121:1999;161-175.
17. Kasai H., Crain P.F., Kuchino Y., Nishimura S., Otsuyanta A., Tunooka H. Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis. 7:1986;1849-1851.
18. Wei H., Frenkel K. Suppression of tumor promoter-induced oxidative events and DNA damage in vivo by sarcophytol A: a possible mechanism of antipromotion. Cancer Res. 52:1992;2298-2303.
19. Pick E., Keisari Y. A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. J. Immunol. Methods. 38:1980;161-170.
20. Wei H., Tye L., Bresnick E., Brit D.F. Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice. Cancer Res. 50:1990;499-502.
21. Smart R.C., Huang M.T., Conney A.H. sn-1,2-Diacylglycerols mimic the effects of 12-O-tetradecanoylphorbol-13-acetate in vivo by inducing biochemical changes associated with tumor promotion in mouse epidermis. Carcinogenesis. 7:1986;1865-1870.
22. Slaga T.J., Das S.B., Rice J.M., Thompson S. Fractionation of mouse epidermal chromatin components. J. Invest. Dermatol. 63:1974;343-349.
23. O'Brien T.G., Simsiman R.C., Boutwell R.K. Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor-promoting agents. Cancer Res. 35:1975;1662-1670.
24. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
25. Kelloff G.J., Hawk E.T., Karp J.E., Crowell J.A., Boone C.W., Steele V.E., Lubet R.A., Sigman C.C. Progress in clinical chemoprevention. Semin. Oncol. 24:1997;241-252.
26. Singh A., Singh S.P., Bamezai R. Modulatory influence of chlorophyllin on the mouse skin papillomagenesis and xenobiotics detoxication system. Carcinogenesis. 17:1996;1459-1463.
27. Xu M., Orner G.A., Bailey G.S., Stoner G.D., Horio H.T., Dashwood R.H. Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline. Carcinogenesis. 22:2001;309-314.
28. Tachino N., Guo D., Dashwood W.M., Yamane S., Larsen R., Dashwood R. Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen. Mutat. Res. 308:1994;191-203.
29. Stocker R., Yamamoto Y., McDonagh A.F., Glazer A.N., Ames B.N. Bilirubin is an antioxidant of possible physiological importance. Science. 235:1987;1043-1046.
30. Patel M., Day B.J. Metalloporphyrin class of therapeutic catalytic antioxidants. Trends Pharmacol. Sci. 20:1999;359-364.
31. Yu J.-W., Yoon S.-S., Yang R. Iron chlorin e6 scavenges hydroxyl radical and protects human endothelial cells against hydrogen peroxide toxicity. Biol. Pharm. Bull. 24:2001;1053-1059.
32. Wang C.-J., Lee M.-J., Chang M.-C., Lin J.-K. Inhibition of tumor promotion in benzo[a]pyrene-initiated CD-1 mouse skin by crocetin. Carcinogenesis. 16:1995;187-191.
33. Kensler T.W., Egner P.A., Moore K.G., Taffe B.G., Twerdok L.E., Trush M.A. Role of inflammatory cells in the metabolic activation of polycyclic aromatic hydrocarbons in mouse skin. Toxicol. Appl. Pharmacol. 90:1987;337-346.
34. Wei H., Frenkel K. Relationship of oxidative events and DNA oxidation in SENCAR mice to in vivo promoting activity of phorbol ester-type tumor promoters. Carcinogenesis. 14:1993;1195-1201.
35. Nakamura Y., Ohto Y., Murakami A., Osawa T., Ohigashi H. Inhibitory effects of curcumin and tetrahydrocurcuminoids on the tumor promoter-induced reactive oxygen species generation in leukocytes in vitro and in vivo. Jpn. J. Cancer Res. 89:1998;361-370.
36. Epe B., Hegler J., Wild D. Identification of ultimate DNA-damaging oxygen species. Environ. Health Perspect. 88:1990;111-115.