Protective effects of hemin and tetrakis(4-benzoic acid)porphyrin on bacterial mutagenesis and mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 472, Issue 1-2, 2000, Pages 139-145

  Chung, Won Yoon ^a   Lee, Jong Min ^a   Lee, Won Young ^b   Surh, Young Joon ^c   Park, Kwang Kyun ^a  

^a Yonsei University College of Dentistry   (South Korea)

^b Yonsei University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Antimutagenicity; Chlorophyllin; Hemin; Mouse skin carcinogenesis; Porphyrins; Tetrakis(4 benzoic acid)porphyrin

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; CHLOROPHYLL; HEMIN; METAL COMPLEX; PHORBOL 13 ACETATE 12 MYRISTATE; PHOTOSENSITIZING AGENT; PORPHYRIN DERIVATIVE; TETRAKIS(4 BENZOIC ACID)PORPHYRIN; UNCLASSIFIED DRUG;

AMES TEST; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CANCER PREVENTION; CHEMICAL MUTAGENESIS; CONTROLLED STUDY; DNA ADDUCT; DNA BINDING; DOSE RESPONSE; FEMALE; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; SKIN CARCINOGENESIS; SKIN CARCINOMA; TREATMENT OUTCOME;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTICARCINOGENIC AGENTS; ANTIMUTAGENIC AGENTS; DNA ADDUCTS; FEMALE; FREE RADICAL SCAVENGERS; HEMIN; HUMANS; METALLOPORPHYRINS; MICE; MICE, INBRED ICR; MUTAGENICITY TESTS; PHOTOCHEMOTHERAPY; SALMONELLA TYPHIMURIUM; SKIN; SKIN NEOPLASMS;

ANIMALIA; BACTERIA (MICROORGANISMS); SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0034695034     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(00)00137-6     Document Type: Article

References (41)

1. Antimutagenicity of the porphyrins and non-enzyme porphyrin-containing proteins
2. Cancer detection and therapy. Affinity of neoplastic, embryonic, and traumatized tissues for porphyrins and metalloporphyrins
3. 6
4. 6 in human bladder carcinoma cells
5. Recent development in anticancer photochemotherapy
6. Antimutagenic activity of some naturally occurring compounds towards cigarette-smoke condensate and benzo[a]pyrene in the Salmonella/microsome assay
7. Inhibition of the mutagenicity of 2-nitrofluoranthene and 1-nitropyrene by vitamins, porphyrins and related compounds, and vegetable and fruit juices and solvent extracts
8. Chemoprevention by natural chlorophylls in vivo: Inhibition of dibenzo[a]pyrene-DNA adducts in rainbow trout liver
9. 1-induced reversion in Salmonella typhimurium strain TA 98
10. Evidence for a radioprotective effect of chlorophyllin in Drosophila
11. Inhibition of benzo[a]pyrene-induced mutagenesis in Chinese hamster V79 cells by hemin and related compounds
12. Chlorophyll and chlorophyllin as modifiers of genotoxic effects
13. Inhibition of 2-amino-3-methylimidazole[4,5-f]quinoline (IQ)-DNA binding by chlorophyllin: Studies of enzyme inhibition and molecular complex formation
14. Inhibitory effects of chlorophyllin on micronucleus formation induced by ethyl carbamate and its proximate and carcinogenic forms in mouse peripheral reticulocytes
15. Adsorption of mutagens to cotton bearing covalently bound trisulfo-copper-phthalocyanine
16. 1 hepatocarcinogenesis in rainbow trout
17. Inhibition by chlorophyllin of 2-amino-3-methylimidazo[4,5-f]quinoline-induced tumorigenesis in the male F344 rat
18. Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogeneis in female F344 rats
19. Chemoprotective activity of chlorophyllin against mouse skin carcinogenesis by benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol-9,10-epoxide
20. Chemopreventive properties of chlorophyllin against vinyl carbamate, p-nitrophenyl vinyl ether and their electrophilic epoxides
21. Inhibitory effects of chlorophyllin on 7,12-dimethylbenz[a]anthracene-induced bacterial mutagenesis and mouse skin carcinogenesis
22. Inhibitory effect of hemin on the mutagenic activities of carcinogens
23. Role of hemin in the inhibition of mutagenic activity of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and other aminoazaarenes
24. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro
25. Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury
26. Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger
27. Metalloporphyrins are potent inhibitors of lipid peroxidation
28. Revised methods for the Salmonella mutagenicity test
29. Formation of 7-hydroxymethyl-12-methylbenz[a]anthracene-DNA adducts from 7,12-dimethylbenz[a]anthracene in mouse epidermis
30. Classification, molecular structure and properties of porphyrins
31. Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: Studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen
32. Binding of polycyclic planar mutagens to chlorophyllin resulting in inhibition of the mutagenic activity
33. Inhibitory effect of hemin, chlorophyllin and related pyrrole pigments on the mutagenicity of benzo[a]pyrene and its metabolites
34. Inhibition of microsome-mediated benzo[a]pyrene metabolism by hemin
35. Non-specific inhibition of cytochrome P450 activities by chlorophyllin in human and rat liver microsomes
36. Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile
37. Effect of sodium copper chlorophyllin on lipid peroxidation. Effect on peroxidative damage of rat liver lysosomes
38. Mechanisms of inhibition of free-radical processes in mutagenesis and carcinogenesis
39. The metabolic activation of chemical carcinogens
40. A quantitative determination of the covalent binding of a series of polycyclic hydrocarbons to DNA in mouse skin
41. Augmentation of 12-O-tetradecanoylphorbol-13-acetate-mediated tumor promoting response by the porphyrin photosensitization of 7,12-dimethylbenz[a]anthracene-initiated murine skin: Role of in situ generated reactive oxygen species