Role of 14-3-3-Mediated p38 Mitogen-Activated Protein Kinase Inhibition in Cardiac Myocyte Survival

Circulation Research

Volumn 93, Issue 11, 2003, Pages 1026-1028

  Zhang, Shaosong ^a   Ren, Jie ^a   Zhang, Cindy E ^a   Treskov, Ilya ^a   Wang, Yibin ^b   Muslin, Anthony J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

14 3 3 protein; Apoptosis; Cardiac; p38 mitogen activated protein kinase; Signal transduction

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN 14 3 3; SYNAPTOPHYSIN;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HEART MUSCLE CELL; MORTALITY; MOUSE; NONHUMAN; PHENOTYPE; PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

14-3-3 PROTEINS; ANIMALS; AORTA; APOPTOSIS; CARDIOMYOPATHY, DILATED; CELL SURVIVAL; CONSTRICTION, PATHOLOGIC; CROSSES, GENETIC; ENZYME INHIBITORS; GENE TARGETING; GENES, DOMINANT; IMIDAZOLES; INJECTIONS, INTRAPERITONEAL; MICE; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCYTES, CARDIAC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; SURVIVAL RATE; TYROSINE 3-MONOOXYGENASE;

EID: 0344011971     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000104084.88317.91     Document Type: Article

References (12)

1. Fu H, Subramanian RR, Masters SC. 14-3-3 proteins: structure, function, and regulation. Annu Rev Pharmacol Toxicol. 2000;40:617-647.
2. Muslin AJ, Xing H. 14-3-3 proteins: regulation of subcellular localization by molecular interference. Cell Signal. 2000;12:703-709.
3. Zhang L, Chen J, Fu H. Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins. Proc Natl Acad Sci USA. 1999;96:8511-8515.
4. Fantl WJ, Muslin AJ, Kikuchi A, Martin JA, MacNicol AM, Gross RW, Williams LT. Activation of Raf-1 by 14-3-3 proteins. Nature. 1994;371:612-614.
5. Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K, Gotoh Y. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science. 1997;275:90-92.
6. Xing H, Zhang S, Weinheimer C, Kovacs A, Muslin AJ. 14-3-3 proteins block apoptosis and differentially regulate MAPK cascades. EMBO J. 2000;19:349-358.
7. Zhang S, Weinheimer C, Courtois M, Kovacs A, Zhang CE, Cheng AM, Wang Y, Muslin AJ. The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis. J Clin Invest. 2003;111:833-841.
8. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 1999;6:857-868.
9. L. Cell. 1996;87:619-628.
10. Kang YJ, Zhou ZX, Wang GW, Buridi A, Klein JB. Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases. J Biol Chem. 2000;275:13690-13698.
11. Klein JB, Wang GW, Zhou Z, Buridi A, Kang YJ. Inhibition of tumor necrosis factor-α-dependent cardiomyocyte apoptosis by metallothionein. Cardiovasc Toxicol. 2002;2:209-218.
12. Sharov VG, Todor A, Suzuki G, Morita H, Tanhehco EJ, Sabbah HN. Hypoxia, angiotensin-II, and norepinephrine mediated apoptosis is stimulus specific in canine failed cardiomyocytes: a role for p38 MAPK, Fas-L and cyclin D1. Eur J Heart Fail. 2003;5:121-129.