CSF hypocretin-1 levels in restless legs syndrome

Neurology

Volumn 61, Issue 10, 2003, Pages 1426-1429

  Stiasny Kolster, Karin ^a,c   Mignot, E ^b   Ling, L ^b   Moller J C ^a   Cassel, W ^a   Oertel, W H ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^c Center of Nervous Diseases   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACID; OREXIN A;

ADULT; AGED; ARTICLE; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; EXTRACTION; FEMALE; HUMAN; MALE; MEASUREMENT; ONSET AGE; POLYSOMNOGRAPHY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RESTLESS LEGS SYNDROME; TIME;

EID: 0344011467     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000094196.50155.38     Document Type: Article

References (10)

1. Allen R, Mignot E, Ripley B, Hishino S, Early C. Increased CSF hypocretin (orexin) in idiopathic restless legs syndrome. Neurology 2002;59: 639-641.
2. Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E. Hypocretin (orexin) deficiency in human narcolepsy. Lancet 2000;355:39-40.
3. Ripley B, Overeem S, Fujiki N, et al. CSF hypocretin/orexin levels in narcolepsy and other neurological conditions. Neurology 2001;57:2253-2258.
4. Mignot E, Lammers GJ, Ripley B, et al. The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Arch Neurol 2002;59:1553-1562.
5. Hagan JJ, Leslie RA, Patel S, et al. Orexin A activates locus coeruleus cell firing and increases arousal in rat. Proc Natl Acad Sci USA 1999; 96:10911-10916.
6. Nacamura T, Uramura K, Nambu T, et al. Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system. Brain Res 2000;873:181-187.
7. Wu MF, John J, Maidment N, Lam HA, Siegel JM. Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement. Am J Physiol Regul Integr Comp Physiol 2002;283: R1079-1086.
8. Torterolo P, Yamuy J, Sampogna S, Morales FR, Chase MH. Hypocretinergic neurons are primarily involved in activation of the somatomotor system. Sleep 2003;26:25-28.
9. Salomon RM, Ripley B, Kennedy JS, et al. Diurnal variation of CSF hypocretin-1 (orexin-A) levels in control and depressed subjects. Biol Psychiatry 2003 (in press).
10. Zeitzer JM, Buckmaster CL, Parker KJ, et al. Circadian and homeostatic regulation of hypocretin in a primate model: implications for the consolidation of wakefulness. J Neurosci 2003;23:3555-3560.