Inhibition of papain with 2-benzyl-3,4-epoxybutanoic acid esters. Mechanistic and stereochemical probe for cysteine protease catalysis

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 11, 1997, Pages 2103-2108

  Kim, Dong H ^a   Yonghao, Jin ^a   Ho Ryu, Choon ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

're' face attack; Active site directed inhibitor; Competitive inhibitor; Inhibitory stereochemistry; Papain

Indexed keywords

2 BENZYL 3,4 EPOXYBUTANOIC ACID METHYL ESTER; CYSTEINE PROTEINASE; PAPAIN; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROLYSIS; STEREOCHEMISTRY;

BINDING SITES; BUTYRATES; CATALYSIS; CYSTEINE PROTEINASE INHIBITORS; ENZYME ACTIVATION; ESTERS; MOLECULAR PROBES; PAPAIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0343990765     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)00147-8     Document Type: Article

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