Morphologic and biochemical changes in male rat lung after surgical and pharmacological castration

Brazilian Journal of Medical and Biological Research

Volumn 33, Issue 3, 2000, Pages 279-285

  Ojeda, M S ^a   Gomez N N ^a   Gil, E ^a   Scardapane, L ^a   Gimenez, M S ^a  

^a UNIVERSIDAD NACIONAL DE SAN LUIS   (Argentina)

Author keywords

Antiandrogens; Flutamide; Lung; Lung morphology; Phospholipids

Indexed keywords

ANTIANDROGEN; FLUTAMIDE; LUNG SURFACTANT; PHOSPHOLIPID;

ARTICLE; CASTRATION; DRUG EFFECT; LUNG FUNCTION; MICROSOME; PHOSPHOLIPID BLOOD LEVEL; STRUCTURE ACTIVITY RELATION; TESTOSTERONE BLOOD LEVEL;

EID: 0343963793     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2000000300004     Document Type: Article

References (22)

1. Jobe A (1988). The role of surfactant in neonatal adaptation. Perinatology, 12: 123-133.
2. Hallman M, Spragg R, Harrell JH & Moser KM (1982). Evidence of lung surfactant abnormality in respiratory failure. Journal of Clinical Investigation, 70: 673-683.
3. Scarpelli EM (1998). The alveolar surface network. A new anatomy and its physiological significance. Anatomical Record, 251: 491-527.
4. Morishige E & Uetake CA (1978). Receptors for androgen and estrogen in the rat lung. Endocrinology, 102: 1827-1837.
5. Ojeda MS, Gomez NN & Gimenez MS (1997). Androgen regulation of lung lipids in the male rat. Lipids, 12: 57-62.
6. Simard J, Luthy Y, Belanger A & Labrie F (1986). Characteristics of interaction of the antiandrogen Flutamide with androgen receptor in various target tissues. Molecular and Cellular Endocrinology, 44: 261-270.
7. Kallio PJ, Janne OA & Palvino JJ (1994). Agonist but not antagonists alter the conformation of the hormone-binding domain of the androgen receptor. Endocrinology, 134: 998-1001.
8. Tsai MJ & O'Malley BW (1994). Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annual Review of Genetics, 25: 89-123.
9. Mulder E & Kuil CW (1996). Deoxyribonucleic acid-binding ability of androgen receptors in whole cells: Implications for the action of androgens and antiandrogens, Endocrinology, 137: 1870-1877.
10. Sardanons ML, de las Heras MA, Calandra RS, Solano AR & Podesta EJ (1989). Effect of the antiandrogen flutamide on pituitary LH content and release. Neuroendocrinology, 50: 211-216.
11. Adachi H, Hayashi H, Sato H, Dempo K & Akino T (1989). Characterization of phospholipids accumulated in pulmonary surfactant compartments of rats intratracheally exposed to silica. Biochemical Journal, 262: 781-786.
12. Kuroki Y & Akino T (1991). Pulmonary surfactant protein A (SP-A) specially binds dipalmitoylphosphatidylcholine. Journal of Biological Chemistry, 266: 3068-3073.
13. Rouser G, Fluster S & Yamamoto A (1970). Two dimensional thin-layer chromatographic separation of polar lipid and determination of phospholipids analysis of spots. Lipids, 5: 494-496.
14. Ojeda MS (1995). Lipids of male rat lung. Effects of the androgens suppressed. Doctoral thesis, National University of San Luis, Argentina.
15. Mendelson CR & Boggaram V (1991). Hormonal control of the surfactant system in fetal lung. Annual Review of Physiology, 53: 415-440.
16. Nielsen HC, Zinman HM & Torday JS (1982). Dihydrotestosterone inhibits fetal rabbit pulmonary surfactant production. Journal of Clinical Investigation, 69: 611-616.
17. Nielsen HC (1985). Androgen receptors influence the production of pulmonary surfactant in the testicular feminization mouse fetus. Journal of Clinical Investigation, 76: 177-181.
18. Klain JM & Nielsen HC (1993). Androgen regulation of epidermal growth factor receptor binding activity during fetal rabbit lung development. Journal of Clinical Investigation, 91: 425-431.
19. Jobe A & Ikegami M (1987). Surfactant for the treatment of respiratory distress syndrome. American Review of Respiratory Disease, 136: 1256-1275.
20. Sweezey NB, Ghibu F, Gagnon S, Schotman E & Hamid Q (1998). Glucocorticoid receptor mRNA and protein in fetal rat lung in vivo: modulation by glucocorticoid and androgen. American Journal of Physiology, 275: L103-L109.
21. Torday JS (1990). Androgens delay human fetal lung maturation in vitro. Endocrinology, 126: 3240-3244.
22. Tadzhiev FS (1991). Changes in plasma levels of corticosterone, testosterone and estradiol and their receptors in the lung cytosol in experimental fibrosing process in the lungs. Problemy Tuberkuleza, 3: 60-62.