Deoxyribonucleic acid-binding ability of androgen receptors in whole cells: Implications for the action of androgens and antiandrogens

Endocrinology

Volumn 137, Issue 5, 1996, Pages 1870-1877

  Kuil, Cor W ^a   Mulder, Eppo ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANTIANDROGEN; BICALUTAMIDE; CYPROTERONE ACETATE; HYDROXYFLUTAMIDE; MIFEPRISTONE; NILUTAMIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DNA BINDING; HORMONE RECEPTOR INTERACTION; HORMONE RESPONSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION;

EID: 0029990959     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.5.8612526     Document Type: Article

References (50)

1. Laudet V, Hänni C, Coll J, Catzeflis F, Stéhelin D 1992 Evolution of the nuclear receptor gene superfamily. EMBO J 11:1003-1013
2. Jenster G, van der Korput HAGM, van Vroonhoven C, van der Kwast ThH, Trapman J, Brinkmann AO 1991 Domains of the human androgen receptor involved in steroid hinding, transcriptional activation, and subcellular localization. Mol Endocrinol 5:1396-1404
3. Simental JA, Sar M, Lane MV, French FS, Wilson EM 1991 Transcriptional activation and nuclear targeting signals of the human androgen receptor. J Biol Chem 266:510-518
4. Evans R 1988 The steroid and thyroid hormone receptor superfamily. Science 240:889-895
5. Beato M 1989 Gene regulation by steroid hormones. Cell 56:335-344
6. Allan GF, Leng X, Tsai SY, Weigel NL, Edwards DP, Tsai M-J, O'Malley BW 1992 Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation. J Biol Chem 267:19513-19520
7. Baniahmed A, Tsai M-J 1993 Mechanisms of transcriptional activation by steroid hormone receptors. J Cell Biochem 51:151-156
8. Tsai M-J, O'Malley BW 1994 Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Gen 25: 89-123
9. Vegeto E, Allan GF, Schräder WT, Tsai M-J, McDonnell DP, O'Malley BW 1992 The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. Cell 69:703-713
10. Weigel NL, Beck CA, Estes PA, Prendergast P, Altmann M, Christensen K, Edward DP 1992 Ligands induce conformational changes in the carboxyl-terminus of progesterone receptors which are detected by a site-directed antipeptide monoclonal antibody. Mol Endocrinol 6:1585-1597
11. Zeng Z, Allan GF, Thaller C, Cooney AJ, Tsai SY, O'Malley BW, Tsai MJ 1994 Detection of potential ligands for nuclear receptors in cellular extracts. Endocrinology 135:248-252
12. Kuil CW, Berrevoets CA, Mulder E 1995 Ligand-induced conformational alterations of the androgen receptor analysed by limited trypsinization. J Biol Chem 270:27569-27577
13. Kallio PJ, Jänne OA, Palvimo JJ 1994 Agonists, but not antagonists, alter the conformation of the hormone-binding domain of the androgen receptor. Endocrinology 134:998-1001
14. Moudgil VK, Hurd C 1987 Transformation of calf uterine progesterone receptor: analysis of the process when receptor is bound to progesterone and RU486. Biochemistry 26:4993-5001
15. Segnitz B, Gehring U 1990 Mechanism of action of a steroidal antiglucocorticoid in lymphoid cells. J Biol Chem 265:2789-2796
16. Truss M, Bartsch J, Beato M 1994 Antiprogestins prevent progesterone receptor binding to hormone responsive elements in vivo. Proc Natl Acad Sci USA 91:11333-11337
17. Reese JC, Katzenellenbogen BS 1992 Examination of the DNA-binding ability of estrogen receptor in whole cells: implications for hormone-independent transactivation and the action of antiestrogens. Mol Cell Biol 12:4531-4538
18. Delabre K, Guiochon-Mantel A, Milgrom E 1993 In vivo evidence against the existence of antiprogestins disrupting receptor binding to DNA. Proc Natl Acad Sci USA 90:4421-4425
19. Agarwal MK 1994 Analysis of steroid receptor domains with the aid of antihormones. Int J Biochem 26:341-350
20. Mymryk JS, Archer TK 1995 Dissection of progesterone receptor-mediated chromatin remodeling and transcriptional activation in vivo. Genes Dev 9:1366-1376
21. Metzger D, Berry M, Ali S, Chambon P 1995 Effects of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo. Mol Endocrinol 9:579-591
22. Ruiter PE de Teuwen R, Trapman J, Dijkema R, Brinkmann AO 1995 Synergism between androgens and protein kinase-C on androgen-regulated gene expression. Mol Cell Endocrinol 110:R1-R6
23. Brinkmann AO, Faber PW, Van Rooij HCJ, Kuiper GGJM, Ris C, Klaassen P, Van der Korput JAGM, Voorhorst MM, Van Laar JH, Mulder E, Trapman J 1989 The human androgen receptor: domain structure, genomic organization and regulation of expression. J Steroid Biochem 34:307-310
24. Veldscholte J, Ris-Stalpers C, Kuiper GGJM, Jenster G, Berrevoets C, Claassen E, Van Rooij HCJ, Trapman J, Brinkmann AO, Mulder E 1990 A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens. Biochem Biophys Res Commun 173:534-540
25. Jenster G, Trapman J, Brinkmann AO 1993 Nuclear import of the androgen receptor. Biochem J 293:761-768
26. Roche PJ, Hoare SA, Parker MG 1992 A consensus DNA-binding site for the androgen receptor. Mol Endocrinol 6:2229-2235
27. Veldscholte J, Berrevoets CA, Brinkmann AO, Grootegoed JA, Mulder E 1992 Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation. Biochemistry 31: 2393-2399
28. Kuiper GGJM, de Ruiter PE, Trapman J, Boersma WJA, Grootegoed JA, Brinkmann AO 1993 Localization and hormonal stimulation of phosphorylation sites in the LNCaP-cell androgen receptor. Biochem J 291:95-101
29. Kemppainen JA, Lane MV, Sar M, Wilson EM 1992 Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. J Biol Chem 267:968-974
30. Culig Z, Hobisch A, Cronauer MV, Cato ACB, Hittmair A, Radmayr C, Eberie J, Bartsch G, Klocker H 1993 Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgen and progesterone. Mol Endocrinol 7:1541-1550
31. Baulieu EE 1989 Contragetion and other clinical applications of RU 486, an antiprogesterone at the receptor. Science 248:1351-1357
32. Philibert D, Costerousse G, Gaillard-Moquilewski M, Nedelec L, Nique F, Tounemine C, Teutsch G 1990 From RU 38486 towards dissociated antiglucocorticoid and antiprogesterone. In: Agarwal MK (ed) Antagonists in Health and Disease. Karger, Basel, Switzerland, pp 1-17
33. Levine M, Manley JL 1989 Transcriptional repression of eukaryotic promoters. Cell 59:405-408
34. Freedman LP 1992 Anatomy of the steroid receptor zinc finger region. Endocr Rev 13:129-146
35. Krongrad A, Wilson CM, Wilson JD, Allman DR, McPhaul MJ 1991 Androgen increases androgen receptor protein while decreasing receptor mRNA in LNCaP cells. Mol Cell Endocrinol 76:79-88
36. Kuiper GGJM, de Ruiter PE, Grootegoed JA, Brinkmann AO 1991 Synthesis and post-translational modification of the androgen receptor in LNCaP-cells. Mol Cell Endocrinol 80:63-73
37. Jenster G, de Ruiter PE, van der Korput HAGM, Kuiper GGJM, Trapman J, Brinkmann AO 1995 Changes in abundance of androgen receptor isotypes: effects of ligand treatment, glutamine-stretch variation, and mutation ot putative phosphorylation sites. Biochemistry 33:14064-14072
38. Xie Y-B, Sui Y-P, Shan L-X, Palvimo JJ, Philips DM, Jänne OA 1992 Expression of androgen receptor in insect cells. J Biol Chem 267: 4939-4948
39. Kuiper GGJM, de Ruiter PE, Trapman J, Jenster G, Brinkmann AO 1993 In vitro translation of androgen receptor cRNA results in an activated receptor protein. Biochem J 296:161-167
40. Wong C, Zou Z, Sar M, Wilson EM 1993 Steroid requirement for androgen receptor dimerization and DNA binding. J Biol Chem 268:19004-19012
41. Kaspar F, Klocker H, Denninger A, Cato A 1993 A mutant androgen receptor from patients with Reifenstein syndrome: identification ot the function of a conserved alanine residue in the D box of steroid receptors. Mol Cell Biol 13:7850-7858
42. Hu MCT, Davidson N 1987 The inducible lac operator-repressor system is functional in mammalian cells. Cell 48:555-566
43. Meyer ME, Gronemeyer H, Turcotte B, Bocquel MT, Tasset D, Chambon P 1989 Steroid hormone receptors compete for factors that mediate their enhancer function. Cell 57:433-442
44. Bagchi MK, Tsai SY, Tsai M-J, O'Malley BW 1991 Progesterone enhance target gene transcription by receptor free of heat-shock proteins hsp90, hsp57 and hsp70. Mol Cell Biol 11:4998-5004
45. Dennis M, Poellinger L, Wikstrom A, Gustafsson JA 1988 Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA binding state. Nature 333:686-688
46. Meyer ME, Pornon A, Ji J, Bocquel MT, Chambon P, Gronemeyer H 1990 Agonist and antagonist activities of RU486 on the functions of the human progesterone receptor. EMBO J 9:3923-3932
47. DeMarzo AM, Oñate SA, Nordeen SK, Edwards DP 1992 Effects of the steroid antagonist RU846 on dimerization of the human progesterone receptor. Biochemistry 31:10491-10501
48. Klein-Hitpass L, Cato A, Henderson D, Ryffel G 1993 Two types of antiprogestins identified by their differential action in transcriptionally active extracts from T47D cells. Nucleic Acids Res 19:1227-1234
49. Green S 1990 Modulation of oestrogen receptor activity by oestrogens and anti-oestrogens. J Steroid Biochem Mol Biol 37:747-751
50. McDonnell DP, Clemm DL, Hermann T, Goldman ME, Pike JW 1995 Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens. Mol Endocrinol 9:659-669