Neuronal and astroglial response to pre- and perinatal exposure to delta-9-tetra-hydrocannabinol in the rat substantia nigra

Developmental Neuroscience

Volumn 22, Issue 4, 2000, Pages 253-263

  Suarez I ^a   Bodega, G ^a   Ramos, J A ^b   Fernandez Ruiz J J ^b   Fernandez B ^b  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Astrocytes; Cannabinoids; Dopaminergic neurons; Glial fibrillary acidic protein; Tyrosine hydroxylase; 9 Tetrahydrocannabinol

Indexed keywords

DRONABINOL; GLIAL FIBRILLARY ACIDIC PROTEIN; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MACROGLIA; MALE; NERVE CELL; NERVE CELL DIFFERENTIATION; NONHUMAN; PERINATAL PERIOD; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUBSTANTIA NIGRA;

EID: 0343878783     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000017449     Document Type: Article

References (38)

1. Abel EL (1980): Prenatal exposure to cannabis: A critical review of effects on growth, development and behavior. Behav Neurol Biol 29:137-156.
2. Acquas E, Carboni E, DiChiara G (1991): Profound depression of mesolimbic dopamine release after morphine withdrawal in dependent rats. Eur J Pharmacol 193:133-134.
3. Björklund A, Lindvall O (1975): Dopamine in dendrites of substantia nigra neurons: Suggestions for a role in dendritic terminals. Brain Res 83: 531-537.
4. 9-tetrahydrocannabinol on the fetal and early postnatal development of tyrosine hydroxylase-containing neurons in the rat brain. J Mol Neurosci 7:291-308.
5. 9-tetrahydrocannabinol affects the gene expression and the activity of tyrosine hydroxylase during early brain development. Life Sci 56:2177-2184.
6. Bonnin A, de Miguel R, Rodriguez-Manzaneque JC, Fernández-Ruiz JJ, Santos A, Ramos JA (1994): Changes in tyrosine hydroxylase gene expression in mesencephalic catecholaminergic neurons in immature and adult male rats perinatally exposed to cannabinoids. Dev Brain Res 81:147-150.
7. Bradford HF (1986): Glial cells: Mechanical and functional supporting cells of the nervous system; in Bradford HF (ed): Chemical Neurobiology. New York, Freeman.
8. Brock JW, Ng JP, Justice JB Jr (1990): Effect of chronic cocaine on dopamine synthesis in the nucleus accumbens as determined by microdialysis with NSD-1015. Neurosci Lett 117:234-239.
9. Craft RM, Stratmann JA (1996): Discriminative stimulus effects of cocaine in female versus male rats. Drug Alcohol Depend 42:27-37.
10. Dalterio SL (1986): Cannabinoid exposure: Effects on development. Neurobehav Toxic Teratol 8: 345-352.
11. Eng LF (1985): Glial fibrillary acidic protein (GFAP): The major protein of glial intermediate filaments in differentiated astrocytes. J Neuroimmunol 8:203-214.
12. Fernández Ruiz JJ, Bonnin A, Cebeira M, Ramos JA (1994): Ontogenic and adult changes in the activity of hypothalamic and extrahypothalamic dopaminergic neurons after perinatal cannabinoid exposure; in Palomo T, Archer T (eds): Strategies for Studying Brain Disorders. London, Ferrand, vol 1, pp 357-390.
13. Fernández Ruiz JJ, Rodriguez de Fonseca F, Navarro M, Ramos JA (1992): Maternal cannabinoid exposure and brain development: Changes in the ontogeny of dopaminergic neurons; in Bartke A, Murphy LL (eds): Neurobiology and neurophysiology of cannabinoids, biochemistry and physiology of substance abuse. Boca Raton, CRC Press, vol IV, pp 119-164.
14. García-Segura LM, Suárez I, Segovia S, Tranque PA, Calés JM, Aguilera P, Olmos G, Guillamón A (1988): The distribution of glial fibrillary acidic protein in the adult rat brain is influenced by the neonatal levels of sex steroids. Brain Res 456:357-363.
15. Gingras JL, Weese-Mayer DE, Hume RF Jr, O'Donnell KJ (1992): Cocaine and development: Mechanisms of fetal toxicity and neonatal consequences of prenatal cocaine exposure. Early Hum Dev 31:1-24.
16. Groves PM, Linder JC (1983): Dendro-dendritic synapses in substantia nigra: Descriptions based on analysis of serial sections. Exp Brain Res 49:209-217.
17. Hansson E. Rönnbäck L (1988): Neurons from substantia nigra increase the efficacy and potency of second messenger arising from striatal astroglia dopamine receptor. Glia 1:393-397.
18. Hutchings DE, Morgan B, Brake SC, Shi T, Lasalle E (1987): Delta-9-tetrahydrocannabinol during pregnancy in the rat. I. Differential effects on maternal nutrition, embryotoxicity and growth in the offspring. Neurotoxic Teratol 9:39-43.
19. Jung-Testas I, Renoir M, Bugnard H, Greene GL, Baulieu EE (1992): Demonstration of steroid hormone receptors and steroid action in primary cultures of rat glial cells. Steroid Biochem Mol Biol 41:815-821.
20. Lirth E, Towle AC, Lauder JM (1989): Neuronalglial interactions: Quantitation of astrocytic influences on development of catecholamine neurons. Neurochem Res 14:979-985.
21. Ma ZQ, Spreafico E, Pollio G, Santagati S, Conti E, Cattaneo E, Maggi A (1993): Activated estrogen receptor mediates growth arrest and differentiation of a neuroblastoma cell line. Proc Natl Acad Sci USA 90:3740-3744.
22. Manthorpe M, Rudge JS, Varon S (1986): Astroglial cell contributions to neuronal survival and neuritic outgrowth; in Vernadakis A, Fedoroff S (eds): Astrocytes. New York, Academic Press, pp 315-376.
23. Mirmiran M, Swaab DF (1987): Influence of drugs on brain neurotransmitter and behavioral states during development. Dev Pharmacol Ther 10:377-384.
24. Noisin EL, Thomas WE (1988): Ontogeny of dopaminergic function in the rat midbrain tegmentum, corpus striatum and frontal cortex. Dev Brain Res 41:241-252.
25. O'Malley EK, Sieber B-A, Black IB, Dreyfus CF (1992): Mesencephalic type I astrocytes mediate the survival of substantia nigra dopaminergic neurons in culture. Brain Res 582:65-70.
26. O'Malley EK, Sieber B-A, Morrison RS, Black IB, Dreyfus CF (1994): Nigral type I astrocytes release a soluble factor that increases dopaminergic neuron survival through mechanisms distinct from basic fibroblast growth factor. Brain Res 647:83-90.
27. Rawithch AB, Schultz GS, Kurt EE (1977): Competition of delta-9-tetrahydrocannabinol with estrogens in rat uterine estrogen receptor binding. Science 197:1189-1191.
28. Rodriguez de Fonseca F, Cebeira M, Fernández-Ruiz JJ, Navarro M, Ramos JA (1991): Effects of pre- and perinatal exposure to hashish extracts on the ontogeny of brain dopaminergic neurons. Neuroscience 43:713-723.
29. Rodriguez de Fonseca F, Cebeira M, Hernández ML, Ramos JA, Fernández-Ruiz JJ (1990): Changes in brain dopaminergic indices induced by perinatal exposure to cannabinoids in rats. Dev Brain Res 51:237-240.
30. Rodriguez de Fonseca F, Cebeira M, Ramos JA, Martín M, Fernández-Ruiz JJ (1994): Cannabinoid receptors in rat brain areas: Sexual differences, fluctuations during estrous cycle and changes after gonadectomy and sex steroid replacement. Life Sci 54:159-170.
31. 9-tetrahydrocannabinol on dopaminergic activity in several rat brain areas. Pharmacol Biochem Behav 42:269-275.
32. Scallet AC, Uemura E, Andrews A, Ali SF, McMillan DE, Paule MG, Brown RM, Slikker W Jr (1987): Morphometric studies of the rat hippocampus following chronic delta-9-tetrahydrocannabinol (THC). Brain Res 436:193-198.
33. Suárez I, Bodega G, Arilla E, Fernández B (1997): Region-selective glutamine synthetase expression in the rat central nervous system following portocaval anastomosis. Neuropathol Appl Neurobiol 23:254-261.
34. Suárez I, Bodega G, Rubio M, Fernández B (1992): Sexual dimorphism in the hamster cerebellum demonstrated by glial fibrillary acidic protein (GFAP) and vimentin immunoreactivity. Glia 5:10-16.
35. Suárez I, Fernández B, Bodega G, Tranque P, Olmos G, García-Segura LM (1987): Postnatal development of glial fibrillary acidic protein immunoreactivity in the hamster arcuate nucleus. Dev Brain Res 37:89-95.
36. Tahir SK, Trogadis JE, Stevens JK, Zimmerman AM (1992): Cytoskeletal organization following cannabinoid treatment in undifferentiated and differentiated PC12 cells. Biochem Cell Biol 70:1159-1173.
37. Tranque P, Suárez I, Olmos G, Fernández B, García-Segura LM (1987): Estradiol-induced redistribution of glial fibrillary acidic protein immunoreactivity in the rat brain. Brain Res 406: 348-351.
38. Yuri K, Kawata M (1994): Estrogen receptor-immunoreactive neurons contain calcitonin gene-related peptide, methionine-enkephalin or tyrosine hydroxylase in the female rat preoptic area. Neurosci Res 21:135-141.